Our bodies have an immune system, which is a complex network of special cells and organs that defends the body from germs and other foreign invaders. At the core of the immune system is the ability to tell the difference between self and nonself: what's you and what's foreign. A flaw can make the body unable to tell the difference between self and nonself. When this happens, the body makes autoantibodies (AW-toh-AN-teye-bah-deez) that attack normal cells by mistake. At the same time, special cells called regulatory T cells fail to do their job of keeping the immune system in line. The result is a misguided attack on your own body. This causes the damage we know as autoimmune disease. The body parts that are affected depend on the type of autoimmune disease. There are more than 80 known types.

Overall, autoimmune diseases are common, affecting more than 23.5 million Americans. They are a leading cause of death and disability. Some autoimmune diseases are rare, while others, such as Hashimoto's disease, affect many people.

Autoimmune diseases can affect anyone. Yet certain people are at greater risk, including:

• Women of childbearing age — More women than men have autoimmune diseases, which often start during their childbearing years.
• People with a family history — Some autoimmune diseases run in families, such as lupus and multiple sclerosis. It is also common for different types of autoimmune diseases to affect different members of a single family. Inheriting certain genes can make it more likely to get an autoimmune disease. But a combination of genes and other factors may trigger the disease to start.
• People who are around certain things in the environment — Certain events or environmental exposures may cause some autoimmune diseases, or make them worse. Sunlight, chemicals called solvents, and viral and bacterial infections are linked to many autoimmune diseases.
• People of certain races or ethnic backgrounds — Some autoimmune diseases are more common or affect certain groups of people more severely. For instance, type 1 diabetes is more common in white people. Lupus is most severe for African-American and Hispanic people.

The diseases listed here either are more common in women than men or affect many women and men. They are listed in alphabetical order.

Although each disease is unique, many share hallmark symptoms, such as fatigue, dizziness, and low-grade fever. For many autoimmune diseases, symptoms come and go, or can be mild sometimes and severe at others. When symptoms go away for a while, it's called remission. Flares are the sudden and severe onset of symptoms.

Chronic fatigue syndrome, also known as myalgic encephalomyelitis, or ME/CFS, and fibromyalgia (feye-broh-meye-AL-juh) (FM) are not autoimmune diseases. But they often have symptoms of some autoimmune disease, like being tired all the time and pain.

• ME/CFS can cause you to be very tired, have trouble concentrating, feel weak, and have muscle pain. Symptoms of ME/CFS come and go. The cause of ME/CFS is not known.
• FM is a disorder in which pain or tenderness is felt in multiple places all over the body. These "tender points" are located on the neck, shoulders, back, hips, arms, and legs and are painful when pressure is applied to them. Other symptoms include fatigue, trouble sleeping, and morning stiffness. FM mainly occurs in women of childbearing age. But children, the elderly, and men are sometimes can also get it. The cause is not known.

Getting a diagnosis can be a long and stressful process. Although each autoimmune disease is unique, many share some of the same symptoms. And many symptoms of autoimmune diseases are the same for other types of health problems too. This makes it hard for doctors to find out if you really have an autoimmune disease, and which one it might be. But if you are having symptoms that bother you, it's important to find the cause. Don't give up if you're not getting any answers. You can take these steps to help find out the cause of your symptoms:

• Write down a complete family health history that includes extended family and share it with your doctor.
• Record any symptoms you have, even if they seem unrelated, and share it with your doctor.
• See a specialist who has experience dealing with your most major symptom. For instance, if you have symptoms of inflammatory bowel disease, start with a gastroenterologist. Ask your regular doctor, friends, and others for suggestions.
• Get a second, third, or fourth opinion if need be. If your doctor doesn't take your symptoms seriously or tells you they are stress-related or in your head, see another doctor.

Juggling your health care needs among many doctors and specialists can be hard. But specialists, along with your main doctor, may be helpful in managing some symptoms of your autoimmune disease. If you see a specialist, make sure you have a supportive main doctor to help you. Often, your family doctor may help you coordinate care if you need to see one or more specialists. Here are some specialists who treat autoimmune diseases:

• Nephrologist. A doctor who treats kidney problems, such as inflamed kidneys caused by lupus. Kidneys are organs that clean the blood and produce urine.
• Rheumatologist. A doctor who treats arthritis and other rheumatic diseases, such as scleroderma and lupus.
• Endocrinologist. A doctor who treats gland and hormone problems, such as diabetes and thyroid disease.
• Neurologist. A doctor who treats nerve problems, such as multiple sclerosis and myasthenia gravis.
• Hematologist. A doctor who treats diseases that affect blood, such as some forms of anemia.
• Gastroenterologist. A doctor who treats problems with the digestive system, such as inflammatory bowel disease.
• Dermatologist. A doctor who treats diseases that affect the skin, hair, and nails, such as psoriasis and lupus.
• Physical therapist. A health care worker who uses proper types of physical activity to help patients with stiffness, weakness, and restricted body movement.
• Occupational therapist. A health care worker who can find ways to make activities of daily living easier for you, despite your pain and other health problems. This could be teaching you new ways of doing things or how to use special devices. Or suggesting changes to make in your home or workplace.
• Speech therapist. A health care worker who can help people with speech problems from illness such as multiple sclerosis.
• Audiologist. A health care worker who can help people with hearing problems, including inner ear damage from autoimmune diseases.
• Vocational therapist. A health care worker who offers job training for people who cannot do their current jobs because of their illness or other health problems. You can find this type of person through both public and private agencies.
• Counselor for emotional support. A health care worker who is specially trained to help you to find ways to cope with your illness. You can work through your feelings of anger, fear, denial, and frustration.

There are many types of medicines used to treat autoimmune diseases. The type of medicine you need depends on which disease you have, how severe it is, and your symptoms. Treatment can do the following:

• Relieve symptoms. Some people can use over-the-counter drugs for mild symptoms, like aspirin and ibuprofen for mild pain. Others with more severe symptoms may need prescription drugs to help relieve symptoms such as pain, swelling, depression, anxiety, sleep problems, fatigue, or rashes. For others, treatment may be as involved as having surgery.
• Replace vital substances the body can no longer make on its own. Some autoimmune diseases, like diabetes and thyroid disease, can affect the body's ability to make substances it needs to function. With diabetes, insulin injections are needed to regulate blood sugar. Thyroid hormone replacement restores thyroid hormone levels in people with underactive thyroid.
• Suppress the immune system. Some drugs can suppress immune system activity. These drugs can help control the disease process and preserve organ function. For instance, these drugs are used to control inflammation in affected kidneys in people with lupus to keep the kidneys working. Medicines used to suppress inflammation include chemotherapy given at lower doses than for cancer treatment and drugs used in patients who have had an organ transplant to protect against rejection. A class of drugs called anti-TNF medications blocks inflammation in some forms of autoimmune arthritis and psoriasis.

New treatments for autoimmune diseases are being studied all the time.

Many people try some form of complimentary and alternative medicine (CAM) at some point in their lives. Some examples of CAM are herbal products, chiropractic, acupuncture, and hypnosis. If you have an autoimmune disease, you might wonder if CAM therapies can help some of your symptoms. This is hard to know. Studies on CAM therapies are limited. Also, some CAM products can cause health problems or interfere with how the medicines you might need work. If you want to try a CAM treatment, be sure to discuss it with your doctor. Your doctor can tell you about the possible benefits and risks of trying CAM.

Women with autoimmune diseases can safely have children. But there could be some risks for the mother or baby, depending on the disease and how severe it is. For instance, pregnant women with lupus have a higher risk of preterm birth and stillbirth. Pregnant women with myasthenia gravis (MG) might have symptoms that lead to trouble breathing during pregnancy. For some women, symptoms tend to improve during pregnancy, while others find their symptoms tend to flare up. Also, some medicines used to treat autoimmune diseases might not be safe to use during pregnancy.

If you want to have a baby, talk to your doctor before you start trying to get pregnant. Your doctor might suggest that you wait until your disease is in remission or suggest a change in medicines before you start trying. You also might need to see a doctor who cares for women with high-risk pregnancies.

Some women with autoimmune diseases may have problems getting pregnant. This can happen for many reasons. Tests can tell if fertility problems are caused by an autoimmune disease or an unrelated reason. Fertility treatments are able to help some women with autoimmune disease become pregnant.

Although most autoimmune diseases don't go away, you can treat your symptoms and learn to manage your disease, so you can enjoy life! Women with autoimmune diseases lead full, active lives. Your life goals should not have to change. It is important, though, to see a doctor who specializes in these types of diseases, follow your treatment plan, and adopt a healthy lifestyle.

Flares are the sudden and severe onset of symptoms. You might notice that certain triggers, such as stress or being out in the sun, cause your symptoms to flare. Knowing your triggers, following your treatment plan, and seeing your doctor regularly can help you to prevent flares or keep them from becoming severe. If you suspect a flare is coming, call your doctor. Don't try a "cure" you heard about from a friend or relative.

If you are living with an autoimmune disease, there are things you can do each day to feel better:

• Eat healthy, well-balanced meals. Make sure to include fruits and vegetables, whole grains, fat-free or low-fat milk products, and lean sources of protein. Limit saturated fat, trans fat, cholesterol, salt, and added sugars. If you follow a healthy eating plan, you will get the nutrients you need from food.
• Get regular physical activity. But be careful not to overdo it. Talk with your doctor about what types of physical activity you can do. A gradual and gentle exercise program often works well for people with long-lasting muscle and joint pain. Some types of yoga or tai chi exercises may be helpful.
• Get enough rest. Rest allows your body tissues and joints the time they need to repair. Sleeping is a great way you can help both your body and mind. If you don't get enough sleep, your stress level and your symptoms could get worse. You also can't fight off sickness as well when you sleep poorly. When you are well-rested, you can tackle your problems better and lower your risk for illness. Most people need at least 7 to 9 hours of sleep each day to feel well-rested.
• Reduce stress. Stress and anxiety can trigger symptoms to flare up with some autoimmune diseases. So finding ways to simplify your life and cope with daily stressors will help you to feel your best. Meditation, self-hypnosis, and guided imagery, are simple relaxation techniques that might help you to reduce stress, lessen your pain, and deal with other aspects of living with your disease. You can learn to do these through self-help books, tapes, or with the help of an instructor. Joining a support group or talking with a counselor might also help you to manage your stress and cope with your disease.

You have some power to lessen your pain! Try using imagery for 15 minutes, two or three times each day. 

1. Put on your favorite calming music.
2. Lie back on your favorite chair or sofa. Or if you are at work, sit back and relax in your chair.
3. Close your eyes.
4. Imagine your pain or discomfort.
5. Imagine something that confronts this pain and watch it "destroy" the pain.

For more information about autoimmune diseases, call the OWH Helpline at 1-800-994-9662 (TDD: 888-220-5446) or contact the following organizations:

• National Heart, Lung, and Blood Institute (NHLBI), NIH, HHS 
  Phone: 301-592-8573
• National Institute of Allergy and Infectious Diseases (NIAID), NIH, HHS 
  Phone: 866-284-4107
• National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, HHS 
  Phone: 301-495-4484; Toll-Free: 877-226-4267
• National Institute of Diabetes and Digestive and Kidney Diseases, NIH, HHS 
  Phone: 301-496-3583
• National Institute of Neurological Disorders and Stroke (NINDS), NIH, HHS 
  Phone: 800-352-9424
• American Autoimmune Related Diseases Association (AARDA), Inc. 
  Phone: 586-776-3900; 800-598-4668 (for literature requests)

• Chronic fatigue syndrome fact sheet
• Fibromyalgia fact sheet
• Graves' disease fact sheet
• Hashimoto's disease fact sheet
• Inflammatory bowel disease fact sheet
• Lupus fact sheet
• Myasthenia gravis fact sheet
• Stress and your health fact sheet
• Thyroid disease fact sheet