호모 사피엔스 종의 단백질 코드 유전자
페이서 (루비콘 유사체로도 알려져 있음)는 사람에서 RUBCNL [5] 유전자 에 의해 암호화되는 단백질 입니다.페이서는 PI3KC3의 조절을 통해 세포 오토파지 를 증가시키는 것으로 나타났습니다. [6]
페이서는 작은 GTPase Rab7에 결합 을 매개 하는 RH(Rubicon homology) 도메인을 C 말단에 포함합니다.[7] [8] 이 도메인은 가족 구성원 루비콘 및 PLEKHM1 을 포함하는 RH 도메인과 공유됩니다.[9] 페이서가 자기식성 활동을 상향조절하는 것처럼 보이는 반면, 루비콘은 자기식성 의 [9]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000102445 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000034959 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "RUBCNL - Protein associated with UVRAG as autophagy enhancer - Homo sapiens (Human) - RUBCNL gene & protein" . www.uniprot.org . Retrieved 2022-05-31 .^ Cheng, Xiawei; Ma, Xiuling; Ding, Xianming; Li, Lin; Jiang, Xiao; Shen, Zhirong; Chen, She; Liu, Wei; Gong, Weihua; Sun, Qiming (2017-03-16). "Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17" . Molecular Cell . 65 (6): 1029–1043.e5. doi :10.1016/j.molcel.2017.02.010 ISSN 1097-4164 . PMID 28306502 . ^ "RUBCNL - Protein associated with UVRAG as autophagy enhancer - Homo sapiens (Human) - RUBCNL gene & protein" . www.uniprot.org . Retrieved 2022-05-31 .^ Bhargava, Hersh K.; Tabata, Keisuke; Byck, Jordan M.; Hamasaki, Maho; Farrell, Daniel P.; Anishchenko, Ivan; DiMaio, Frank; Im, Young Jun; Yoshimori, Tamotsu; Hurley, James H. (2020-07-21). "Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex" . Proceedings of the National Academy of Sciences of the United States of America . 117 (29): 17003–17010. doi :10.1073/pnas.2008030117 ISSN 1091-6490 . PMC 7382272 PMID 32632011 . ^ a b Beltran, S.; Nassif, M.; Vicencio, E.; Arcos, J.; Labrador, L.; Cortes, B. I.; Cortez, C.; Bergmann, C. A.; Espinoza, S.; Hernandez, M. F.; Matamala, J. M. (2019-03-27). "Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis" . Molecular Neurodegeneration . 14 (1): 14. doi :10.1186/s13024-019-0313-9 . ISSN 1750-1326 . PMC 6437924 PMID 30917850 . 진일보한 내용 Ng D, Hu N, Hu Y, Wang C, Giffen C, Tang ZZ, Han XY, Yang HH, Lee MP, Goldstein AM, Taylor PR (2008). "Replication of a genome-wide case-control study of esophageal squamous cell carcinoma" . Int. J. Cancer . 123 (7): 1610–5. doi :10.1002/ijc.23682 . PMC 2552411 PMID 18649358 . Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O (2009). "Screening for replication of genome-wide SNP associations in sporadic ALS" . Eur. J. Hum. Genet . 17 (2): 213–8. doi :10.1038/ejhg.2008.194 . PMC 2986065 PMID 18987618 . Yang N, Eijsink JJ, Lendvai A, Volders HH, Klip H, Buikema HJ, van Hemel BM, Schuuring E, van der Zee AG, Wisman GB (2009). "Methylation markers for CCNA1 and C13ORF18 are strongly associated with high-grade cervical intraepithelial neoplasia and cervical cancer in cervical scrapings" . Cancer Epidemiol. Biomarkers Prev . 18 (11): 3000–7. doi :10.1158/1055-9965.EPI-09-0405 PMID 19843677 . Eijsink JJ, Lendvai Á, Deregowski V, Klip HG, Verpooten G, Dehaspe L, de Bock GH, Hollema H, van Criekinge W, Schuuring E, van der Zee AG, Wisman GB (2012). "A four-gene methylation marker panel as triage test in high-risk human papillomavirus positive patients". Int. J. Cancer . 130 (8): 1861–9. doi :10.1002/ijc.26326 . PMID 21796628 . S2CID 35295117 . Huisman C, Wisman GB, Kazemier HG, van Vugt MA, van der Zee AG, Schuuring E, Rots MG (2013). "Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors" . Mol Oncol . 7 (3): 669–79. doi :10.1016/j.molonc.2013.02.017 . PMC 5528488 PMID 23522960 .
