胆固醇侧链裂解酶

胆固醇侧链裂解酶
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 3NA1、​3N9Y、​3N9Z、​3NA0
識別號
别名	CYP11A1；, CYP11A, CYPXIA1, P450SCC, cytochrome P450 family 11 subfamily A member 1
外部ID	OMIM：118485 MGI：88582 HomoloGene：37347 GeneCards：CYP11A1
相關疾病
congenital adrenal insufficiency
為以下藥物的標靶
米托坦、​氨鲁米特
基因位置（人类） 染色体 15號染色體 基因座 15q24.1 起始 74,337,759 bp 终止 74,367,646 bp
基因位置（小鼠） 染色体 小鼠9号染色体 基因座 9 B|9 31.63 cM 起始 57,913,694 bp 终止 57,934,306 bp
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • iron ion binding • 金屬離子結合 • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • cholesterol monooxygenase (side-chain-cleaving) activity • 血浆蛋白结合 細胞組分 • 膜 • 线粒体基质 • 線粒體 • mitochondrial inner membrane 生物學過程 • vitamin D metabolic process • C21-steroid hormone metabolic process • 脂質代謝 • cholesterol metabolic process • C21-steroid hormone biosynthetic process • sterol metabolic process • steroid biosynthetic process • steroid metabolic process • glucocorticoid biosynthetic process • cellular response to peptide hormone stimulus • cortisol metabolic process Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	1583	13070
Ensembl	ENSG00000140459 ​ENSG00000288362	ENSMUSG00000032323
UniProt	P05108	Q9QZ82
mRNA​序列	NM_001099773 ​NM_000781	NM_019779 ​NM_001346787
蛋白序列	NP_000772 ​NP_001093243	NP_001333716 ​NP_062753
基因位置​（UCSC）	Chr 15: 74.34 – 74.37 Mb	Chr 9: 57.91 – 57.93 Mb
PubMed​查找
維基數據
檢視/編輯人類 檢視/編輯小鼠

胆固醇侧链裂解酶（英語：Cholesterol side-chain cleavage enzyme，CYP11A1或P450scc，其中“scc”是“side-chain 侧链”“cleavage 裂解”的缩写）是一种将胆固醇转化为孕烯醇酮的线粒体酶。这是所有哺乳动物中由胆固醇生成各种甾类激素的第一步反应。

胆固醇 + 3 NADPH + 3 H⁺ + 3 O₂ ⇄ 孕烯醇酮 + 4-甲基戊醛 + 3 NADP⁺ + 3 H₂O

P450scc 是细胞色素P450氧化酶超家族的一员（家族11亚家族A多肽1），基因名为 CYP11A1。

另见

• 类固醇生成酶
• 细胞色素P450

延伸阅读

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