GL261

GL261（Glioma 261）是一种常用于科研用途的小鼠神经胶质瘤细胞系，最初是通过颅内注射甲基胆甾醇，然后将肿瘤片段连续地颅内移植和皮下移植到C57BL/6小鼠（英语：C57BL/6）体内诱导的^[1]。1990年代中期，已有多个研究小组从肿瘤中建立了永生细胞系。

特征

GL261肿瘤在组织学上类似于成脑室管膜细胞瘤（Ependymoblastoma），但显示出许多胶质母细胞瘤的表型特征。它们包含突变的KRAS基因（英语：KRAS）及p53肿瘤蛋白，导致C-Myc的高度表达。 GL261肿瘤具有部分免疫原性，因为它们高度表达着MHC1类分子，并且发现MHC2类分子（英语：MHC class II）、CD80和CD86的表达有限。GL261肿瘤是浸润性及非转移性的，目前已知道它不会自发消退^[2]^[3]。GL261是帮助研究神经胶质瘤的小鼠模型，其他具有免疫能力且适合研究神经胶质瘤的细胞系包括GL26、CT-2A、SMA-560及4C8^[4]。

参考资料

^ Ausman, JI; Shapiro, WR; Rall, DP. Studies on the chemotherapy of experimental brain tumors: development of an experimental model.. Cancer research. 1970-09, 30 (9): 2394–400 [2020-01-11]. PMID 5475483. （原始内容存档于2020-01-11）.
^ Jacobs, VL; Valdes, PA; Hickey, WF; De Leo, JA. Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model.. ASN neuro. 2011-08-03, 3 (3): e00063 [2020-01-11]. PMID 21740400. doi:10.1042/AN20110014. （原始内容存档于2020-01-11）.
^ Szatmári, T; Lumniczky, K; Désaknai, S; Trajcevski, S; Hídvégi, EJ; Hamada, H; Sáfrány, G. Detailed characterization of the mouse glioma 261 tumor model for experimental glioblastoma therapy.. Cancer science. 2006-06, 97 (6): 546–53 [2020-01-11]. PMID 16734735. doi:10.1111/j.1349-7006.2006.00208.x. （原始内容存档于2020-01-11）.
^ Oh, T; Fakurnejad, S; Sayegh, ET; Clark, AJ; Ivan, ME; Sun, MZ; Safaee, M; Bloch, O; James, CD; Parsa, AT. Immunocompetent murine models for the study of glioblastoma immunotherapy.. Journal of translational medicine. 2014-04-29, 12: 107 [2020-01-11]. PMID 24779345. doi:10.1186/1479-5876-12-107. （原始内容存档于2020-01-11）.

外部链接

Cellosaurus entry for GL261（页面存档备份，存于互联网档案馆）

[1] Ausman, JI; Shapiro, WR; Rall, DP. Studies on the chemotherapy of experimental brain tumors: development of an experimental model.. Cancer research. 1970-09, 30 (9): 2394–400 [2020-01-11]. PMID 5475483. （原始内容存档于2020-01-11）.

[2] Jacobs, VL; Valdes, PA; Hickey, WF; De Leo, JA. Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model.. ASN neuro. 2011-08-03, 3 (3): e00063 [2020-01-11]. PMID 21740400. doi:10.1042/AN20110014. （原始内容存档于2020-01-11）.

[3] Szatmári, T; Lumniczky, K; Désaknai, S; Trajcevski, S; Hídvégi, EJ; Hamada, H; Sáfrány, G. Detailed characterization of the mouse glioma 261 tumor model for experimental glioblastoma therapy.. Cancer science. 2006-06, 97 (6): 546–53 [2020-01-11]. PMID 16734735. doi:10.1111/j.1349-7006.2006.00208.x. （原始内容存档于2020-01-11）.

[4] Oh, T; Fakurnejad, S; Sayegh, ET; Clark, AJ; Ivan, ME; Sun, MZ; Safaee, M; Bloch, O; James, CD; Parsa, AT. Immunocompetent murine models for the study of glioblastoma immunotherapy.. Journal of translational medicine. 2014-04-29, 12: 107 [2020-01-11]. PMID 24779345. doi:10.1186/1479-5876-12-107. （原始内容存档于2020-01-11）.

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