The reason so many make Ghost in the Shell Comparisons is that this series was conceived by none other than legendary Mangaka/Creator Masamune Shirow, the man who created Ghost in the Shell, as well as Dirty Pair and Appleseed.
While this has a serious central plot, the majority of the series is very Slice-of-Life and quite light with a lot of humour, a lot of it yuri in nature as Nene is constantly hugging and fondling Clarion.
There are plenty of oddball secondary characters, including a lot cute girls doing cute things. It's not very political, but it does get into the idea of playing God. There is a lot to recommend.
The artwork is excellent and the animation quite smooth. The character designs are well though out, with Masamune's influence rather clear, if you know what to look for.
While this is not really a must-see, it IS well worth watching.