NR1H4 Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1OSH , 3BEJ , 3DCT , 3DCU , 3FLI , 3FXV , 3GD2 , 3HC5 , 3HC6 , 3L1B , 3OKH , 3OKI , 3OLF , 3OMK , 3OMM , 3OOF , 3OOK , 3RUT , 3RUU , 3RVF , 3P88 , 3P89 , 4OIV , 4WVD , 4QE6 , 4QE8
Dynodwyr Cyfenwau NR1H4 Dynodwyr allanol OMIM: 603826 HomoloGene: 3760 GeneCards: NR1H4 Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • sequence-specific DNA binding • DNA binding • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001105 transcription coactivator activity • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • retinoid X receptor binding • steroid hormone receptor activity • bile acid binding • GO:0001948, GO:0016582 protein binding • nuclear receptor binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • chenodeoxycholic acid binding • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • bile acid receptor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • RNA polymerase II transcription regulator complex Prosesau biolegol • Notch signaling pathway • cellular triglyceride homeostasis • cellular response to organonitrogen compound • regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of ammonia assimilation cycle • toll-like receptor 4 signaling pathway • immune system process • histone H3-R17 methylation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of glutamate metabolic process • intracellular bile acid receptor signaling pathway • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • regulation of low-density lipoprotein particle clearance • regulation of bile acid biosynthetic process • regulation of cholesterol metabolic process • regulation of urea metabolic process • intracellular receptor signaling pathway • negative regulation of bile acid biosynthetic process • cellular response to fatty acid • bile acid and bile salt transport • nitrogen catabolite activation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • inflammatory response • innate immune response • GO:0072468 signal transduction • steroid hormone mediated signaling pathway • fatty acid homeostasis • GO:1903106 positive regulation of insulin receptor signaling pathway • cellular response to lipopolysaccharide • negative regulation of interleukin-2 production • positive regulation of insulin secretion involved in cellular response to glucose stimulus • negative regulation of inflammatory response • glucose homeostasis • negative regulation of NF-kappaB transcription factor activity • positive regulation of adipose tissue development • cell-cell junction assembly • toll-like receptor 9 signaling pathway • negative regulation of monocyte chemotactic protein-1 production • bile acid metabolic process • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of tumor necrosis factor-mediated signaling pathway • defense response to bacterium • negative regulation of interleukin-1 production • negative regulation of tumor necrosis factor production • negative regulation of interleukin-6 production • triglyceride homeostasis • negative regulation of interferon-gamma production • GO:0009373 regulation of transcription, DNA-templated • bile acid signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of phosphatidic acid biosynthetic process • cholesterol homeostasis • lipid metabolism • multicellular organism development • cell differentiation • lipid homeostasis • cellular glucose homeostasis Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn NR1H4 yw NR1H4 a elwir hefyd yn Farnesoid X nuclear receptor a Nuclear receptor subfamily 1 group H member 4 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q23.1.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR1H4.
BAR
FXR
HRR1
HRR-1
PFIC5
RIP14
"Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets. ". Arterioscler Thromb Vasc Biol . 2017. PMID 28619996 . "Farnesoid X receptor regulates the growth of renal adenocarcinoma cells without affecting that of a normal renal cell-derived cell line. ". J Toxicol Sci . 2017. PMID 28496032 . "Reciprocal regulation of farnesoid X receptor α activity and hepatitis B virus replication in differentiated HepaRG cells and primary human hepatocytes. ". FASEB J . 2016. PMID 27251172 . "Farnesoid X Receptor Expression Reduced in Obese Rat Model With Insulin Resistance. ". Am J Med Sci . 2015. PMID 26488943 . "Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. ". Sci Rep . 2014. PMID 25257666 . 
