PARD3

PARD3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KOM
Dynodwyr
Cyfenwau	PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator
Dynodwyr allanol	OMIM: 606745 HomoloGene: 10489 GeneCards: PARD3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatidylinositol-3-phosphate binding • GO:0001948, GO:0016582 protein binding • phosphatidylinositol-4,5-bisphosphate binding • protein phosphatase binding • phosphatidylinositol-3,4,5-trisphosphate binding • lipid binding • identical protein binding • phosphatidylinositol binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • cell-cell junction • bicellular tight junction • Cellbilen • axonal growth cone • internode region of axon • cell junction • neuronal cell body • cell cortex • Cytosgerbwd • endomembrane system • adherens junction • GO:0009327 protein-containing complex • apical plasma membrane • apical junction complex Prosesau biolegol • establishment of epithelial cell polarity • cell differentiation • axonogenesis • protein targeting to membrane • negative regulation of peptidyl-threonine phosphorylation • myelination in peripheral nervous system • Cellraniad • establishment or maintenance of cell polarity • positive regulation of myelination • regulation of cellular localization • protein kinase C-activating G protein-coupled receptor signaling pathway • asymmetric cell division • bicellular tight junction assembly • cell cycle • transforming growth factor beta receptor signaling pathway • GO:0034622 protein-containing complex assembly • microtubule cytoskeleton organization • cell adhesion • GO:0034613 protein localization • establishment of cell polarity • establishment or maintenance of epithelial cell apical/basal polarity • establishment of centrosome localization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	56288	n/a
Ensembl	ENSG00000148498	n/a
UniProt	Q8TEW0	n/a
RefSeq (mRNA)	NM_001184785 NM_001184786 NM_001184787 NM_001184788 NM_001184789 NM_001184790 NM_001184791 NM_001184792 NM_001184793 NM_001184794 NM_019619	n/a
RefSeq (protein)	NP_001171714 NP_001171715 NP_001171716 NP_001171717 NP_001171718 NP_001171719 NP_001171720 NP_001171721 NP_001171722 NP_001171723 NP_062565	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PARD3 yw PARD3 a elwir hefyd yn Par-3 family cell polarity regulator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10p11.22-p11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PARD3.

• Baz
• ASIP
• PAR3
• PARD-3
• PARD3A
• SE2-5T2
• PPP1R118
• SE2-5L16
• SE2-5LT1
• PAR3alpha

Llyfryddiaeth

• "Cytoplasmic PAR-3 protein expression is associated with adverse prognostic factors in clear cell renal cell carcinoma and independently impacts survival. ". Hum Pathol. 2014. PMID 24856572.
• "The PAR polarity complex and cerebellar granule neuron migration. ". Adv Exp Med Biol. 2014. PMID 24243103.
• "Loss of PAR-3 protein expression is associated with invasion, lymph node metastasis, and poor survival in esophageal squamous cell carcinoma. ". Hum Pathol. 2017. PMID 28188749.
• "Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer. ". BMC Cancer. 2016. PMID 27855669.
• "KSHV-Mediated Regulation of Par3 and SNAIL Contributes to B-Cell Proliferation.". PLoS Pathog. 2016. PMID 27463802.