SERPINB1

SERPINB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4GA7
Dynodwyr
Cyfenwau	SERPINB1, EI, ELANH2, HEL57, LEI, M/NEI, MNEI, PI-2, PI2, HEL-S-27, serpin family B member 1
Dynodwyr allanol	OMIM: 130135 HomoloGene: 133768 GeneCards: SERPINB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • serine-type endopeptidase inhibitor activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • extracellular exosome • bilen • extracellular space • secretory granule lumen • GO:0005578 extracellular matrix • extracellular region • collagen-containing extracellular matrix Prosesau biolegol • negative regulation of peptidase activity • negative regulation of endopeptidase activity • neutrophil degranulation • type B pancreatic cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1992	n/a
Ensembl	ENSG00000021355	n/a
UniProt	P30740	n/a
RefSeq (mRNA)	NM_030666	n/a
RefSeq (protein)	NP_109591	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPINB1 yw SERPINB1 a elwir hefyd yn Serpin family B member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p25.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPINB1.

• EI
• LEI
• PI2
• MNEI
• PI-2
• HEL57
• M/NEI
• ELANH2
• HEL-S-27

Llyfryddiaeth

• "SERPINB1 expression is predictive for sensitivity and outcome of cisplatin-based chemotherapy in melanoma. ". Oncotarget. 2016. PMID 26799424.
• "Serine protease inhibitor (SERPIN) B1 suppresses cell migration and invasion in glioma cells. ". Brain Res. 2015. PMID 24968089.
• "Comparative proteome analysis of peripheral neutrophils from sulfur mustard-exposed and COPD patients. ". J Immunotoxicol. 2015. PMID 24852194.
• "Decreased expression of SERPINB1 correlates with tumor invasion and poor prognosis in hepatocellular carcinoma. ". J Mol Histol. 2014. PMID 24105272.
• "Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis.". Am J Physiol Gastrointest Liver Physiol. 2012. PMID 22421620.