TNFRSF10B

TNFRSF10B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1D0G, 1D4V, 1DU3, 1ZA3, 2H9G, 4I9X, 4N90, 4OD2, 3X3F
Dynodwyr
Cyfenwau	TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, tumor necrosis factor receptor superfamily member 10b, TNF receptor superfamily member 10b
Dynodwyr allanol	OMIM: 603612 HomoloGene: 117702 GeneCards: TNFRSF10B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • TRAIL binding • GO:0001948, GO:0016582 protein binding • tumor necrosis factor-activated receptor activity • signaling receptor activity Cydrannau o'r gell • bilen • Cellbilen • integral component of plasma membrane • cell surface • intracellular anatomical structure • integral component of membrane Prosesau biolegol • activation of NF-kappaB-inducing kinase activity • response to endoplasmic reticulum stress • multicellular organism development • cell surface receptor signaling pathway • response to lipopolysaccharide • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • cellular response to mechanical stimulus • regulation of cell population proliferation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of extrinsic apoptotic signaling pathway via death domain receptors • inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0072468 signal transduction • tumor necrosis factor-mediated signaling pathway • GO:0097285 apoptotic process • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • leukocyte migration • extrinsic apoptotic signaling pathway via death domain receptors • regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • TRAIL-activated apoptotic signaling pathway • positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8795	n/a
Ensembl	ENSG00000120889	n/a
UniProt	O14763	n/a
RefSeq (mRNA)	NM_003842 NM_147187	n/a
RefSeq (protein)	NP_003833 NP_671716	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNFRSF10B yw TNFRSF10B a elwir hefyd yn TNF receptor superfamily member 10b (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8p21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNFRSF10B.

• DR5
• CD262
• KILLER
• TRICK2
• TRICKB
• ZTNFR9
• TRAILR2
• TRICK2A
• TRICK2B
• TRAIL-R2
• KILLER/DR5

Llyfryddiaeth

• "Decreased placental and maternal serum TRAIL-R2 levels are associated with placenta accreta. ". Placenta. 2016. PMID 26992667.
• "Membrane display and functional analysis of juxtacrine ligand-receptor signaling. ". Biotechniques. 2015. PMID 26458551.
• "Death Receptor 5 Activation Is Energetically Coupled to Opening of the Transmembrane Domain Dimer. ". Biophys J. 2017. PMID 28746849.
• "Death Receptor 5 Networks Require Membrane Cholesterol for Proper Structure and Function. ". J Mol Biol. 2016. PMID 27720987.
• "A new oridonin analog suppresses triple-negative breast cancer cells and tumor growth via the induction of death receptor 5.". Cancer Lett. 2016. PMID 27387452.