Peroxirredoxina 2

PRDX2
Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1QMV ;
Identificadores
Nomenclatura	Outros nomes PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxirredoxina-2 ;
Símbolos	PRDX2 (HGNC: 9353) PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxirredoxina-2
Identificadores; externos	OMIM: 600538 ; MGI: 109486 ; HomoloGene: 21182 ; EBI: PRDX2; GeneCards: Xene PRDX2; UniProt: PRDX2;
Locus	Cr. 19 p13.13
Ontoloxía Xénica	Referencias: AmiGO / QuickGO
	Referencias: AmiGO / QuickGO
Padrón de expresión de ARNm
	Máis información
Ortólogos
Especies
Humano	Rato
Entrez
7001	21672
Ensembl
Véxase HS	Véxase MM
UniProt
P32119	Q61171
RefSeq; (ARNm)
NM_181738	NM_011563
RefSeq; (proteína) NCBI
NP_005800	NP_001304314
Localización (UCSC)
Cr. 19:; 12.8 – 12.8 Mb	Cr. 8:; 85.7 – 85.7 Mb
PubMed (Busca)
7001 ;	21672

A peroxirredoxina 2 é unha proteína oxidorredutase que nos humanos está codificada no xene PRDX2 do cromosoma 19.^[1]^[2]

O xene PRDX2 codifica un membro da familia da peroxirredoxina de encimas antioxidantes, os cales reducen o peróxido de hidróxeno a alquil hidroperóxidos. A proteína codificada pode xogar un papel antioxidante protector nas células e pode contribuír á actividade antiviral das células T CD8+. Pode ter un efecto proliferativo e intervir no desenvolvemento e progresión do cancro. A súa estrutura cristalina resolveuse a 0,27 nm (= 2,7 ángstroms). As variantes de transcrición constitúen distintas isoformas que foron identificadas para este xene.^[2]

Notas

↑ Pahl P, Berger R, Hart I, Chae HZ, Rhee SG, Patterson D (agosto de 1995). "Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12". Genomics 26 (3): 602–6. PMID 7607688. doi:10.1016/0888-7543(95)80183-M.
↑ ^2,0 ^2,1 "Entrez Gene: PRDX2 peroxiredoxin 2".

Véxase tamén

Bibliografía

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Anahory T, Dechaud H, Bennes R, et al. (2002). "Identification of new proteins in follicular fluid of mature human follicles.". Electrophoresis 23 (7–8): 1197–202. PMID 11981869. doi:10.1002/1522-2683(200204)23:7/8<1197::AID-ELPS1197>3.0.CO;2-2.
Shen C, Nathan C (2002). "Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells.". Mol. Med. 8 (2): 95–102. PMC 2039972. PMID 12080185. doi:10.1007/BF03402079.
Geiben-Lynn R, Kursar M, Brown NV, et al. (2003). "HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.". J. Biol. Chem. 278 (3): 1569–74. PMID 12421812. doi:10.1074/jbc.M209964200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.

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[pmid7607688-1] Pahl P, Berger R, Hart I, Chae HZ, Rhee SG, Patterson D (agosto de 1995). "Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12". Genomics 26 (3): 602–6. PMID 7607688. doi:10.1016/0888-7543(95)80183-M.

[entrez-2] 2,0 ^2,1 "Entrez Gene: PRDX2 peroxiredoxin 2".

[1]

[2]