RhoD

RHOD
사용 가능한 구조
PDB	동원체 검색: PDBe RCSB
PDB ID 코드 목록
	2J1L
식별자
다른 이름	RHOD, ARHD, RHOHP1, RHOM, Rho, RhoD, ras homolog family member D
외부 ID	OMIM: 605781 MGI: 108446 HomoloGene: 22409 GeneCards: RHOD
유전자 위치 (인간)
염색체	11번 염색체
끝	67,072,017 bp
유전자 위치 (쥐)
염색체	19번 염색체 (쥐)
끝	4,489,460 bp
RNA 발현 패턴
	최상위 발현
	이자관세포; ; 간오른엽; ; apex of heart; ; skin of leg; ; 배의 피부; ; 잇몸; ; gingival epithelium; ; 좌심실; ; skin of thigh; ; 양수;
	최상위 발현
	구형낭; ; otic placode; ; otic vesicle; ; 입술; ; 식도; ; corneal stroma; ; choroid plexus of fourth ventricle; ; right kidney; ; 공장; ; 샘창자;
	추가 참조 발현 데이터
	; ;
	추가 참조 발현 데이터
유전자 온톨로지
분자 함수	nucleotide binding; protein kinase binding; GTP binding; GTPase activity;
세포 성분	early endosome; endosome membrane; 엔도솜; 세포막; 세포액; 세포막; intracellular anatomical structure; 세포질; cell cortex; cell division site; intracellular membrane-bounded organelle;
생물학적 과정	positive regulation of cell adhesion; focal adhesion assembly; actin filament bundle assembly; regulation of actin cytoskeleton reorganization; positive regulation of cell migration; lamellipodium assembly; Rho protein signal transduction; regulation of focal adhesion assembly; 단백질 표적화; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; actin filament organization; regulation of cell shape; cell migration; regulation of cell migration; establishment or maintenance of actin cytoskeleton polarity; regulation of actin cytoskeleton organization;
	출처: Amigo / QuickGO
동원체
	29984
	11854
	ENSG00000173156
	ENSMUSG00000041845
	O00212
	P97348
	NM_014578; NM_001300886
	NM_007485; NM_001329989
	NP_001287815; NP_055393
	NP_001316918; NP_031511
	위키데이터
인간 보기/편집	쥐 보기/편집

Ras 상동 유전자 패밀리, 구성원 D (Ras homolog gene family, member D, RhoD)는 작은(~21kDa) 신호 G단백질이며, GTP에이스의 Rho 패밀리의 Rac 서브패밀리의 구성원이다.^[5] RHOD 유전자에 의해 암호화된다.^[6]

이것은 GTP에 결합하고 엔도솜 역학 및 액틴 세포 골격의 재구성에 관여하며 세포 골격의 기능과 막 수송을 조정할 수 있다.^[6]

상호작용

RhoD는 CNKSR1^[7] 및 DIAPH2와 상호작용하는 것으로 나타났다.^[8]

각주

↑ ^가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000173156 - 앙상블, May 2017
↑ ^가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000041845 - 앙상블, May 2017
↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ Ridley A. (2006). “Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking”. 《Trends Cell Biol》 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823.
↑ ^가 ^나 “Entrez Gene: RHOD ras homolog gene family, member D”.
↑ Jaffe, Aron B; Aspenström Pontus; Hall Alan (Feb 2004). “Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways”. 《Mol. Cell. Biol.》 (United States) 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. ISSN 0270-7306. PMC 344169. PMID 14749388.
↑ Gasman, Stéphane; Kalaidzidis Yannis; Zerial Marino (Mar 2003). “RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase”. 《Nat. Cell Biol.》 (England) 5 (3): 195–204. doi:10.1038/ncb935. ISSN 1465-7392. PMID 12577064.

[refGRCh38Ensembl-1] 가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000173156 - 앙상블, May 2017

[refGRCm38Ensembl-2] 가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000041845 - 앙상블, May 2017

[3] “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[4] “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[Ridley-5] Ridley A. (2006). “Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking”. 《Trends Cell Biol》 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823.

[entrezd-6] 가 ^나 “Entrez Gene: RHOD ras homolog gene family, member D”.

[pmid14749388-7] Jaffe, Aron B; Aspenström Pontus; Hall Alan (Feb 2004). “Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways”. 《Mol. Cell. Biol.》 (United States) 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. ISSN 0270-7306. PMC 344169. PMID 14749388.

[pmid12577064-8] Gasman, Stéphane; Kalaidzidis Yannis; Zerial Marino (Mar 2003). “RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase”. 《Nat. Cell Biol.》 (England) 5 (3): 195–204. doi:10.1038/ncb935. ISSN 1465-7392. PMID 12577064.

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