Basiliksimab
| Klinički podaci | |
|---|---|
| AHFS/Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 152923-56-3 |
| ATC kod | L04AC02 |
| DrugBank | DB00074 |
| ChEMBL[1] | CHEMBL1201439 
|
| Hemijski podaci | |
| Formula | C6378H9844N1698O1997S48 |
| Mol. masa | 143801,3 g/mol |
| Fizički podaci | |
| Tačka topljenja | 61 °C (142 °F) |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 7,2 +/- 3,2 dana |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
| Način primene | Intravenozno |
Basiliksimab (Simulect) je himerno (miš-čovek) monoklonalno antitelo koje je specifično za α lanac (CD25) IL-2 receptora[2] T ćelija. Basiliksimab je rekombinantno antitelo (IgG1k) koje deluje kao imunosupresivni agens. Ono je 144 kDa težak glikoprotein.[3][4]
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Lupo L, Panzera P, Tandoi F, et al. (October 2008). „Basiliximab versus steroids in double therapy immunosuppression in liver transplantation: a prospective randomized clinical trial”. Transplantation 86 (7): 925–31. DOI:10.1097/TP.0b013e318186b8a3. PMID 18852657. Arhivirano iz originala na datum 2012-06-10. Pristupljeno 2014-04-05.
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
