UGT2B15

UGT2B15
Identifikatori
Alijasi	UGT2B15
Spoljašnji ID	OMIM: 600069 MGI: 1919023 HomoloGene: 133957 GeneCards: UGT2B15
Genska lokacija (miš) Hr. Chromosome 5 (mouse) Band 5|5 E1 Start 87,064,497 bp Kraj 87,074,389 bp
Genska ontologija Molecular function • hexosyltransferase activity • glucuronosyltransferase activity • glycosyltransferase activity • transferase activity • retinoic acid binding • UDP-glycosyltransferase activity Cellular component • endoplasmic reticulum membrane • мембрана • intracellular membrane-bounded organelle • саставни део мембране • organelle membrane • ендоплазматични ретикулум Biological process • steroid metabolic process • Glukuronidacija • метаболизам • xenobiotic metabolic process Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	7366	71773
Ensembl	ENSG00000277132 ENSG00000196620	ENSMUSG00000035836
UniProt	P54855	Q8R084
RefSeq (mRNA)	NM_001076	NM_152811
RefSeq (protein)	NP_001067	NP_690024
Location (UCSC)	n/a	Chr 5: 87.06 – 87.07 Mb
PubMed search
Wikidata
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UDP-glukuronoziltransferaza 2B15 je enzim koji je kod ljudi kodiran genom UGT2B15.

Literatura

• Coffman BL, Tephly TR, Irshaid YM (1990). „Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase.”. Arch. Biochem. Biophys. 281 (1): 170—5. PMID 2116769. doi:10.1016/0003-9861(90)90428-2. 
• Irshaid YM, Tephly TR (1987). „Isolation and purification of two human liver UDP-glucuronosyltransferases.”. Mol. Pharmacol. 31 (1): 27—34. PMID 3100939. 
• Green MD, Clarke DJ, Oturu EM (1995). „Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols.”. Arch. Biochem. Biophys. 322 (2): 460—8. PMID 7574722. doi:10.1006/abbi.1995.1489. 
• Green MD, Oturu EM, Tephly TR (1995). „Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.”. Drug Metab. Dispos. 22 (5): 799—805. PMID 7835232. 
• Chen F, Ritter JK, Wang MG (1993). „Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms.”. Biochemistry. 32 (40): 10648—57. PMID 8399210. doi:10.1021/bi00091a015. 
• Guillemette C, Lévesque E, Beaulieu M (1997). „Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells.”. Endocrinology. 138 (7): 2998—3005. PMID 9202245. doi:10.1210/endo.138.7.5226 . 
• Lévesque E, Beaulieu M, Green MD (1997). „Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene.”. Pharmacogenetics. 7 (4): 317—25. PMID 9295060. doi:10.1097/00008571-199708000-00007. 
• Strassburg CP, Strassburg A, Nguyen N (1999). „Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus.”. Biochem. J. 338 (2): 489—98. PMC 1220077 . PMID 10024527. doi:10.1042/0264-6021:3380489. 
• Tchernof A, Lévesque E, Beaulieu M (1999). „Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method.”. Clin. Endocrinol. 50 (5): 637—42. PMID 10468930. S2CID 43030627. doi:10.1046/j.1365-2265.1999.00709.x. 
• Strassburg CP, Kneip S, Topp J (2000). „Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.”. J. Biol. Chem. 275 (46): 36164—71. PMID 10748067. doi:10.1074/jbc.M002180200 . 
• Gsur A, Preyer M, Haidinger G (2002). „A polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk.”. Cancer Epidemiol. Biomarkers Prev. 11 (5): 497—8. PMID 12010866. 
• Iida A, Saito S, Sekine A (2002). „Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8.”. J. Hum. Genet. 47 (10): 505—10. PMID 12376738. doi:10.1007/s100380200075 . 
• Court MH, Duan SX, Guillemette C (2003). „Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9.”. Drug Metab. Dispos. 30 (11): 1257—65. PMID 12386133. doi:10.1124/dmd.30.11.1257. 
• Kanaya J, Takashima M, Koh E, Namiki M (2003). „Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression.”. Asian J. Androl. 5 (1): 9—13. PMID 12646996. 
• Zhang JY, Zhan J, Cook CS (2003). „Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.”. Drug Metab. Dispos. 31 (5): 652—8. PMID 12695355. S2CID 23434477. doi:10.1124/dmd.31.5.652. 
• Tomboc M, Witchel SF (2003). „Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism.”. J. Pediatr. Endocrinol. Metab. 16 (5): 719—26. PMID 12880121. S2CID 32217321. doi:10.1515/jpem.2003.16.5.719. 
• Court MH, Hao Q, Krishnaswamy S (2005). „UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver.”. J. Pharmacol. Exp. Ther. 310 (2): 656—65. PMID 15044558. S2CID 5946464. doi:10.1124/jpet.104.067660. 
• Toide K, Umeda S, Yamazaki H (2005). „A major genotype in UDP-glucuronosyltransferase 2B15.”. Drug Metab. Pharmacokinet. 17 (2): 164—6. PMID 15618667. doi:10.2133/dmpk.17.164. 
• Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). „Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.”. Endocr. Res. 30 (4): 717—25. PMID 15666817. S2CID 10971899. doi:10.1081/ERC-200044014.