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Pathophysiology of Dengue Hemorrhagic Fever

Dengue hemorrhagic fever is caused by the dengue virus transmitted through the bite of an infected Aedes aegypti mosquito. The virus spreads rapidly in the bloodstream and stimulates the immune system. This results in the production of antibodies that can lead to increased vascular permeability. The combination of viral infection, immune response, and increased vascular permeability causes plasma leakage that can lead to dengue hemorrhagic fever.

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305 views3 pages

Pathophysiology of Dengue Hemorrhagic Fever

Dengue hemorrhagic fever is caused by the dengue virus transmitted through the bite of an infected Aedes aegypti mosquito. The virus spreads rapidly in the bloodstream and stimulates the immune system. This results in the production of antibodies that can lead to increased vascular permeability. The combination of viral infection, immune response, and increased vascular permeability causes plasma leakage that can lead to dengue hemorrhagic fever.

Uploaded by

ysse09
Copyright
© Attribution Non-Commercial (BY-NC)
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Pathophysiology of Dengue Hemorrhagic Fever

Predisposing Precipitating
Geographical area – tropical
Environmental conditions (open spaces
with water)
Mosquito carrying dengue virus

Aedes aegypti - dengue virus carrier

Bite from mosquito


(Portal of Entry through
Skin)

Allows dengue virus to be Diagnostic:


immunized towards the Hematology :
Increased WBC:
circulation/blood
Virus disseminated rapidly into the blood 12,900/cumm
and stimulated WBCs including B (5,000-
lymphocytes that produces and secretes 10,000/cumm)
immunoglobulins (antibodies), and Increased
monocyte. Lymphocytes: 49%
(20-
Diagnostic:
Hematology :
Decreased Antibodies attach to the viral
Monocytes: antigens, and then
monocytes/macrophages will
4%(8-14%)
perform phagocytosis through
receptor within the cells and
Decreased
dengue virus replicates in the
Neutrophils:
47%(50-70% cells

Detection of dengue viral


antigen on infected monocytes

Signs/ symptoms: Release of cytokines which consist of


Febrile: 38.2C vasoactive agents such as interleukins,
Warm skin, DENGU
tumor necrosis factor, urokinase and
stomach ache E
platelet activating factors which
5/10 pain scale;
stimulates WBCs and pyrogen release

Diagnostic:
Cellular direct destruction and
Hematology
infection of red bone marrow :
precursor cells as well as Decreased
immunological shortened platelet Platelet:
68,000/cum
Thrombocytopeni
a

Dengue Hemorrhagic
Fever

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