t f.i ft!

,'
.: --
02207 020 / ]APE
/ t4S/ 2 ao
7
C.qRTBBEAN
Ex-qi.{rNeTroNS
couNcrL
ADVANCED PROFTCTEIJCV
ExA-!trNATroNS

BI OLOGY
I'NrT 02 _ PAPER 02
MaRK SCTIETI,E
2OO7
 2 o 22O't o2o / SAPE /MS
/ 2OO7
B]OLOGY

UNTT 02 - FAPER 02
rdARI( SCHE}IE 2OO7

Question 1
UK ]
(a) Gas from
the cut end of the plant is ar-rowed to collect
in the ffared end of the capillary tu;;. ---
The bubble of gas is then drar,/n into
of the capillary tube by means of the the straight part
syringe. ^

The Iength of the bubble in the capiJ.lary tube

measured. is
The bubble is then drawn on into the reservoilr after
thich a new bubble can be admitted into the capillary
tube as before.
- The procedure is repeated as many times as possibJ-e
obtain a consistent set of results ina given to
conditions. set of
5poiats-5marks
5

(b) (i) The rate of photosynthesis rises steadilv

as the
light intensity increases.
The rrate of photosynthesis then leveLs off as the
process reaches its maximum rate.
2 points
- 2 narks 2
1 1>oiDt
- 1 rrark
(ii) At the higher concentration of CO 0.139 there
was an increase in photosynthesis ,,due to more
substrate, CO2, being avail-able,
:- fn both curves A and B, increasing light
provides more energy to excite electrons intensity
2points-2marks
1 point - 1 mark 2
(iii) Any one of the following:
At 0.038 CO2, the low level of CO, is a limiting
factor.
As CO2 conc increases from 0.03? to 0.133, more
substrate, (CO.) is available.
As Iight intensity increases, the photosynthetic I

ra'Le increases. I

Li qht intensit-y linits photosynthesis rvheo it is I

be 1or', 3 arbrtrary units

l po irt ?

Sp=c:fic i;5 j ecLtves: i{rd..ri: 7: 2 ..5

I
3r5
 3 o2 207 020 / 1APE
/ MS / 2lrl.t
EIOI,OGY

ulJrT 02 _ P-qPER 02

}IARK SCIIEME 2OO7

Quest -10n 2
(a) (i)
(ii) u(

o
o

Rectartgrle

Drawing rrell
L:orrect at xl done, re gions s hov,/n and
Proportion s
3tr)oi!,ts_3Earl{s
pr aced 3
ffi:r":;': i"ili*"",
(b) (i) I
A ml-tral,/bicuspid valve
B yein/venule (coronary)
(. valve (in vein
)
D arterioLe ( coronary
)
(ii) E atrium
F ventricle i

I
5 5points-3marks l I
I

I
3 4points_2mar](s I
I
!
1 2points-lmark ts
I I
I
!
 022O7 02O /cApE/Ms
/ 2OA7
BT OLOGY

UNIT 02 - PAPER 02
],,ARK SC'IEME 2OC7
Ouestion 2 ( Cont 'd )

(c) G:II 1:3

=
l points 1 mark

(d) G pump bLood to lungs short

g pump blood to distance
boay _- greater distance
c little resistance in pulmonary
E must overcome resistance circulation
c pressure must be less than"r3=y=i"iit-i-J.li."rr.tion
E pressure must be greater thankpa
l; kpa
c lungs fragile,
-L
:" #=.i*1;
ili' i x"li5, ::; -:::il illi.., or r",
spon

"
pairs of point s _ 2 marks
A-Ey . 2

Specific Objectives: Modu1e 2: 3.2, 3.4

 5 o2207 020 / cAPE / tls
/ 2c('7
BTOLOGY

u&-rT 02 _ PAPER
02
MARK SCIIEME 2OO7
Question 3

(a) (i) 1- contil KC u<

2 - ,""".n:;S*:I"ut"t
I
(ii) 4s t
(iii) approximately 2. 1
2t
(iv) ?heir risk wilf 7
increase 1 mark
(rhe never_ smoked
) ru" continuous].y
Ls. ar - I mark
j
=';;;ffi "i"::" j; j il"j3i.",.] 2

(b) - Sepa-rate
cp A and cp B
- For each individuat r:^ . imrnediatelv
i
- rake rtooa p.""=,L'"I ^r berore exercise
_ ;t";" "
Take pu.lse ( p )
_ Take breqt}Ijng rate
(BR)
_ Subject them to TfMED
exercisr
_ stop exerc-ise and .re_measuaa "n the stairs
,=
3P' pulse' BR at
- carcurate differences end
_ (before and after
Record )
_ Calculate averages for
the Gp a' for BP, p,
- Do same e.aire procedure BR
o with r:ach indiwidual of croup
_ Compare t]
"o
E ror Bp, p, BR
;,".Ti;
co''"'
"ii l:"::=iJr - 4 o'u't.'
"1""1,=".rff=T,:";l;..".::,i."."0 4
so,""_.t.p, "J;::"::':t;riy
".'#i -3 marks
Brief ansrrer, few detailr__-f
inurL
Specific Objectives: trodu_le I
3; 2.4, 2.23 !

4
 5 o 22C7 O2A / CAPE /MS / 2Oo7
BI OLOGY

UNIT 02 - PAFER 02

t.,ARK SCHEME 2OO7

Question 4
XC UK
(a) - Active tran.p"r:- wh-rch energy is needed
f:J- across
movement of materiafs e.g.
u Jlti**.ro.un".
- Anabolic reactic
ffi "*ffi ,'""Xi;oiXIn,n'i.5'i,ii'X,i'IX"'nii,'i;"iiio"=
2points-2marks
1 point - .1 mark.
(b) (i) Glycolysis (sugar spl.i Lt ing) is
reactions in which sugar a series of
dor,rn to two molecu.ies ot
(six-carbon) is broken
pyruvate. the three-carbon
- In the series of
used and .," *"1":;i:".,3i=;",i are
l:.r";;:;:""f,3;, each
molecule of pyruvate 1r"a ."=rii-r-i-i,rrl
.
? pois*-s - 2 :r.a:.ks
2
(ii) clucose molecule is ohosphorylated
of two phosphate g.oip.. by the addition
ATp is used in phosphoryf ation.
The phosphorylated suc
carbon (triose)
",n".',if.ii,i}:: "nr,. into 2 3-
_ One molecu-le js glyceraldehyde
vrhich goes along the glycorytic 3_ohor t"*nl
r.arriX|"a"
- The other triosr
phosphate,ni.n=rX,iEI"r.;r.::I'::II;"::.8ffr.
- Each molecule of
:O"r- is converted by several
steps into one molecule
- fn the convers ic of GAI'P "r pv.i"]I"1,
hydrogen uao*. .'n to pyruvate' two
re removed from the GAI,P and taken
up by NAD,
_ For each cALp *"r::"1. converted I
are released nt"llg a-t:tal, 2 ATp molecules I

an overall net gain of 2 ATp."r < arp'*orecules and I

I
j !",illi; well exprained and wirh correcr
sequea.e 5 1

(c) (i)
 7
02207 020 / 1APE
/ Ms / 2 0r,7
tsroLocy
UNTT 02 - PAPER 02
I,{ARK SCIIEME
2 OO7
0ues tion 4 ( Cont ,d )

RC
cfycolysis occurs und U
-i;'
:l;. IJi : " ". ; ;. ;;"": L i "i j,ij". i, j "1"o,. j,ll = o, .
Only 2 ATp molecu-les produced
cooditions. under anaerobic
- fn aerobic resp:

$*$5lt*T*ii1-"ii:i",-.,l,xi#**i"=
6poiats-6marks 6
(ii) - During vigorous exer.-i <6 +r-^_
demand fo.
-j. '"i:" t" an excessive-
n "rr".q.,--i;;:-
;;;,.: ;: lin r.li Iff "^;j " = ; J;
ilio,,lElo I ""
- The muscles a:
( lactic u"ro to respire e
iliS"' "f "n"' t"
;
f^"*i3-tied i-"^{
.
bu i 1 d up "5Iolt"".t
converted", to
;
" raciate, -;;i
is"'
the exercise .;1:;:.""il,"Tate
wrrrcll accumuLates during
- At the end as
;"*:s:''"""#
the Lj.ver.
j#Jkir";+:*:."ilii.:;.;i:"
ev,werEed back to
pyr,rv.t" i.,
- The build up of
in the *,";i";:*i':::;;:. toxic and causes pain
- As O, debt builc
and.breathinn rl:j"o t1:':.r= an incr in pulse
actr-vlty .ro., As. the n".t;i.""""
ii.ll^- visorous
Any 4 points ,"r. "*n'r1'r',""1 1""_t:*;:odot 4
Specific obj ectives; Modu_Le I:1.1,3.1, 3 2, 4.t, 4.2
10 10
 8 o2207 020 / ?APE / t{S
/ 2c/07
BTOLOGY

U}IIT 02 PAPER 02
T1ARK SCHEME 2OO7

Qu es t.lon 5
( a) Source: KC UK
E Extraterrestrial. Sun,s radianL
N Te rrestrial. SoiI/geochemi;;i" enerov
''.=.r,
Capture entry by proced ure):
E photosynthesis by producers
N Active transport into roots, - electron cycling
from soif.
Consumer
Feed on producers
_ rose r;-i;-;;;;.;_ J:ff:r:I5.:":l;Iii
E
i
transferred to next leve-L :I.T
-
*;=ff,
N Obtained from producers _ incorporated
tissues. Same amount into
on to next revel
1o".tu.,,"J;":;;i'(::"i:iffi,
Decomposer
E Released from organic material
N Break-down materiaLs converted as heat.
to humus -
Flow
E Continuous_Iy 1ost
_ constantly replaced.
N Continuouslyrecycled
soulce aad 2 comparisots, well exI)lained;
2 marks each - 6 marks
Each nutrient leveL must have a reference 6
NutrieDts. to EDergy aDd

(b) A food web is a network of organisms which

several different feedj.ng. r"r"ti"""iip=]'.,e inrzolves
is a finear feedinq,"fuii""=r,if-"i""Ig""i"r. tooa
which nutrients are transferreJ'b;;r;;;';.'" "lui.r,
through
representative only, at each tropic l;;"i,
Food webs retain more nutrients and
minerals in the
componenrs of the
::;.:il":1":iolosicar ".o"y"t"^ th.r, i
The minerars etc in food webs are I

absorption and transfer to a greater more avairabre r.or

j
,uaUJa of
organisms than those in a fooj cirain.-'..'*"' I

The loss/death/elimination of memtrers i

?i f I have lit;f e ef ieci on the var.retyof a food r.;eb

I

a:tci f io,, of
rutl:renis, comoa:ed wr-.1 loss .. ri.;.-'.r"]ooo
:
J

chai..
cIrcuia;inE r.iirtriilills ir.: sori,
;:.;=;r:;;:.in"I."]."oa.
=;-o.:.:;s ,:.' ;.;,,tit ici;,-_;n 4 :i':rir s
3 p; il;,s f .,-an,o l;l5 rn
._r
3 ri1-t r:{:i
Z po i:t i.; ) i .: a) .r)a, n . i :, .)
,-l 2 ,1 lili J
1 r,,' i r, i . r .,:;;15.;-,
;'
,,_ ii(
 9
o2207 A20 / 1APE
/t4s / 2007
B I OTOGY

UNr? 02 - PAPER
02
MARK SCEEME 2OO7
Oue s ti.on 5 (Cont,d)
(c) De f o rest a t ion,/ xc t,
s1 as h/burn
etc _ the source i:':1"fl:'"":,i;;;;:T;.
".Sr.Ii", .n"
No organic litter
The sou.rce
c
avaj lable is -
""
Nitrifying bacteria
compounds is
"r*"rl,,lu1us missing-
=corchld i"Jl.ii"'lo,:i:i:i:#;:s, Hitrouacter ;
No substrate for pr(
p.r-ants cannot of nitrites and
ooa.rn'ou:aton nitrates,
nitrates via roots-
,,lants cannot ,.n"
ot s' enzlzmes' pigments
Plants become stuntel
cannot photosyntti".
Return r.ittfe ritt..d,' iz
".

$"r:i:.:rff::{ii;:_#+"il:l;"" die ou,,

I".:::i;;rf#1,3"3,""=.""#inn ," ,. n""",s or cannot
_ f.oss of h
.remnants i,ffi ffS:= ross of soir. moisture,
_ soil
Or are err by rain,/weather.
_ lacterr.a'oro
-
ou..", in."olliirt, :t""tn i nh ibi t ed, environment
becomes
IO brief poiEts
s r,r"ri -.*i'i.'-csd'- releva.t
1o rnarks
points :
specific objectives: - each
i{odure rt 6.5, a.r, - 10 marks
,]rtut*s to
10 10
 10 02207 A20 / :APE / Ms / 2007
BTOIOGY

UNIT 02 - PAPER 02
.VARK SCIiEME 2007

Ouestio n6
KC UK
(a) Iil

Bowlnall, s
capsu 1e Glomerulus Proximal convoluted tubule

t-

Collecting ducb
IJoop of Ifen le

5
Ascending. limb of loop of Herlle
Descending l imb of Loop of IIenIi:
cooddiagra.rn-2marks
'sketchy, diagram _ 1 mark
5-5labels-3marks
3-4labeLs-2marks
l-2labels-1mark
(ii) _ f_oop of ilenle has two regions _
a descenciing and an
ascending limb togetheruiar, . p.r"ii"i'oro"a
capurary system (vasa recta). -;;;;;-;";"-;;Jation
achieved throush operation .; . ;;;;;";"current is
pin) exchange system in an" ,""n-"r^riJir". thair_

ii;"ff '.f .":.'""'"'ff";^iff

:"::,tT"TS, "ar"r,-ru j:r;.:"',..#:o*
frorn .it and deposited ln tn"
(salt concentration decreases "ri.o,]"iinn _
).
_ Salt equilibrates with. fluid in the descending
thereby making the satt concenl"if limb
descending f.imb more concentrated ""- .f. in.
ascending 1iinb. This constitua", than ttuiO in the
in"'""r,"aer_current
- The rasult of this 5
hish sarr resion o1
"u..ounJrIjT;:'":ir.':.f;;duceLa j
I

As f iuid f 1o,/r's do!.rn the coilecting duct,

out of it into the surround meduliary water passes j

J""; I
I

5 points clearly ouL]ined _ 5 mdrks

(i) ?:ecaaac..' aesri:s 1:l ai titcaaa-se.i]l:lte
ue -ir:ei?l]
!-ol uie o: :luti ;o
an licr=3se ]r urea ::rcduc:icr c,ue ice:oe:u:
? po-1..:r: s
t)_
 11 o 2207 O2O / 1APE /Lrs / 2Oo7
BTOIOGY

UNrT 02 - pApER 02
I{ARK SCIIEME 2OO7
Question 6 (Cont,d)
(c) Hi gh g.Iucose .leve1 sl KC UK
thal pgr'56r may be
srit"iinq i."r-.r=jdi::":t=(possibry
Diabetic condition coes late onset).
production of in.rti.,'ll-.1:. 9" to inadequare
or rrom tu.s.t-;Jii=-"riiiill':, rrom panJreatic disease
concentrate i"=*,iiii l.lrng to responci to the normal
High ",
protein leve-l
to
-aisease-f":;. =;":i:ji-1".
cr o:" to kidney
( i n a de qu a t e t i...., o,,"i] "
r i ;;;" ;;"; i Ti'nii""t;;;;, "
3;
sixty year age is sio

;;""?ii::i;"'""Ti**--,1=r*1,t-,*r":::'" a
4 l,re.l I explained points
3 LreII exl)]-aitred aDd I - I marks
brief _ 6 marks, etc
Partial ex1rJ.anatior for
eachpoirt_lmark
Specific Objectives: [rodule
2z 5.2, 5.4, 5.6
ro F;-
 12 o22O7 a2O /1APE
/MS I 2Qo7
BrO!OGY

UNIT 02 - PAPER 02
}L\RK SCHEME 2OO7
Ouestion 7

(a) (i) UK
af(on
Ins .

m
PS knob
o0
o o
oo o o oo

Pre. S. M.
Post El.naptic
a.rrd area s. cleft
Post. S.M.

:::y1lg must
.lnc-tusion
be tarse, ctear,
_proportionate v/ith celL
correctly drav/n to shor4r
these structures
- pre_synaptic knob -

- syDa-ot i c claft
- post_synaptic arealneuron
_ pre and post synapt-ic membranes.
(both labels = 1 mark)
4points_4marks
3 poiDts _ 3 marks, etc I
(ii) AdditionaL l-abels (structures
must be drav/n)
- axon
_ synaptic vesicles
_ myelin sheath
_ mitochondria
ADy4labels_2marks
2-3labels_lmark
L label _ O marks 2
(iii) Sequentia.L steps
- a-rrivaf of impulse in synapt.ic
knob
- change in permeability of pr.e_synap-L-rc
men11orane I
- calcium .ions eniel pre_synaptic
iilembrare i
_ sytaptic v,asic.Ies move :o/botaal I
,iih lx_-;xbfane
- dcr'. -vlcrol j I e (-.ions;ni,.r
e:- ) .c_:JS.,d j,,c.,
sYnapiic ciefi
- difiusas acioss cL3i-t
aa;:CieS iC JaS, _::../itap;:C L-a:!t,rlJ:aa-
.!.:. ,, = :r.ri.rr-s _ :, -, .... .
 1?
02207 020/1APE/t.{S
/ 2007
Br OI,OGY

UNIT 02 - PAPER 02
I'IARX SCIIEME 2OO7

Question 7 (Cont,d)

(b) kc L
(i) Receipt of an jmpuls".:I
.. single synaptic knob,
or smaLl, group is inaoeguate.
The initiaL reception
- .r.e. ,,prepares, the synapse.
l_l_ lr"
stimulus FA.TLTTATE.
fncreasing numbers
at the synapse- anci successive irnpulses arrive
The cumulative increase
stimulation _ is called in strength enables
suui,tATroN.
Any3points_3uarks
(ii) The reflex s timulates
prepare t o r" r. --=-"* -t-;" tl:= ic kn ob to
i#""3:
An alternate nerve pat
impulse - - --;hway sends an inhibitory
Causes inhibitor Inot A^,, r
svnaptic knob of li.t:":l:: ^_ l" be secreted by the
_

The inhibito. ,o,

""ot Pathwa,'
synaptic block either the p*.e-
"""."tio;":.les
bfock the __",r-_urs
receptor on the post_syhaptic
membrane.
The post_synaptic
l:*JS;" il:T:#i" li
;::: "tS.'
;:.'" :;iTl.." Y.
AEy3points_3nrarks
(c) N use axons, dendrons
e bI ood -;;. ji,.." 3
E us
"y;;;; ; r=3.'Ir'f,1i,
N target cells in precise focation
E target cells may be
or widespread
r

N verv specific action'l:t-l: -rs stimulated I

E g"r"r.f ,"aio, oylu, tY
cells, e.9. groe/th
N short lived I
E longer durat ion I

I
}I efectrical _ involves I
I

specia-tJ, uno -ve charges !

!
I

..;hich ii i .;;;;;;;:,::=':.ur".,
"..r.ir..0'.lYu usu.r ry p.o:. in=, i 1

r --.:
-4
Hv ^L-Ls _ + na!.ks
'r
3points-3marks
Sr atemenis can .be seoi rr I e J, but e.:cir .,q: ilusi !!
c,:mp J e.neer ,;;'-o;,
";:"
JtJ.j.ar r.: ubj.:tit.s:
J.1.Cu l3
" 5".\,
:!.
 L4 O 2 2O7 O2O / cAp!. / Ms / 2OO 7

EIOLOGY

uNrr 02 PAPER 02

}[ARK SCIIEME 2 OO7

Question 8
lrx
(a) (i) - Hfv _ human immunodeficiency virus _is a
retrovirus which infects imirune in
particular T helper lymphocytes ""li=
(CD4 ceLls).
- Once within the cell the viral RNA is transfated
into DNA and incorporated into the DNA of the
host nucleus.
- AIDS, which may develop, is a variety of
infections which result from the abnirrnal
destruction of the T helper cells.
3points-3marks
3
(il) weakened immune system results in individuafs
being vulnerable to opportunisti. i"f""iior=
cryptosporidio s i s, pneumocystis, pneumonia. e.g.
Hfv* individuafs could exbibit enlargement of the
Iymph nodes.
May exhibit non-specific symptoms such as
ti-redness, sweating, rashes.
Kaposi, s sarcoma may dev_Iop-
Brain disease riay develop resuJ-ting in dementia
and paralysis.
5 points - 5 marks
5
(iii1: AIDS is now a major cause of death in the region.
Caribbean ranks second in the worfd for Efv
infection rates.
Infection rates range from 2 _ 7Z in the
countries. I

Disease is now no 1on9er restricted to I

homosexuals : now a heterosexual disease_
I
younger age group n o\,7 affected in age I

.i 5 ye ars
range 15 _
.

Economic impact significant drain on re source s i

I

for heafth care. I

i
Af fectj ng ianily Lrf e r,rhe:- e chtidren are witholtt
I

parents. i

Ai iecting tha vror^: ioic. OI th: Caitbb:l an e,c

Irri::oveC eciiicatio'taf ;';are ne S S '., -.

r lr irr';!JC.
aransr-lii. 3C cirsease,
.--'1
-i1aS 1in-1rks
 15 a2 207 020 / 3APE /MS
/ 20r7
Br OLOGY

UNIT 02 - PAPER 02
I,I]IRK SCEEME 2OO7
Questio n8 (Cont,d)

(b) (i) xc I
l'="':t],:^_t:_"ot spread by direct human contact
disease but
;:=;"I."::::-borne transmitted by
- Humans becorne ir
f ii:i:,"r*t*.ti"*t":It=,..,iil,"i;iilto,r,.
2points_2narks
( ii.1 niological factors relate 2
the parasite. t-o the rife cycfe
of
Control could be acl
e'g- guppies-r;; ;;:'ffffod predators
Application of insec
i#::.or
(larvae to kirl mosquitoes
";; ;;"ii:;:ticides -
Use of drugs to kifl
parasjtes. blood stages of the
Devefopment of vaccir
prevention could tntt"* brood stages.
be ,'tt.
::nljn;:::;fJ#,-"T liil' :Tsr:lis IT : *
u::=:i" :J"ii..# T" :i I "i" r:";:".I..,
t r., e
",_
1:rl"_or. of mossuito habits
- b a-m. approx. - nocturnal, 6 p-m
_ painting interior 5
walfs v/hile, using
_ Using nets as barriers, fans
cover skin at night.
"* f ff,','l; fftiil:"" _- f ;::l:,
Specific Objective(s): "."
Module 3: 2.6, 2.7,
Z.A
 16 02 207 02A / C.APE / Ms / 2ao7

BTOLOGY

UNIT 02 PAPER 02

MARK SCHEME 2OO7

Question 9
UK
(a) (i) There are restriction endonucleotidases specific
to certain DNA base sequences. They cut and
separate linear DNA at these sites. 1
They are found in bacteria.
To cut,/break bonds of phage virus DNA prevent
virus from infecting bacterial ce11. I
A suitable seDtence for each point _ 1 mark each
(ii) A - Obtain the required gene or DNA fragment
- Use restriction enzlnnes to cut DNA to obtain
these.
Use the manufactured vector plasmid
(pBR322 ) .
The vector plasmid must be ident_ifiable:
pBR322 has genes for ampicillin and
-'rycacycl-ine resistance.
Mix the DNA fragments and vector plasmid.
Allow DNA to be taken up by vector plasnid.
B fntroduce bacterial culture, e.g. E coli.
Add calcium chl_oride to facilitate uptake of
pfasmids by E co1i.
Al1o9, bacteria to clone increase nulr 3er.
Plate bacteria on culture containing
antibiotic No. 1 (ampicillin),
Those bacteria without vector wifl die. The
remainder (afive) possess the vector.
Note: - The cutting of the plasmid and
inserting the DNA fragment deletes
./inactivates the second antibiotic gene of
the plasrdd which confers resistance to
tetracycl-ine.
I
The bacteria are -uhen plated onto cu-Iture
containing tetracycfine. Any bacteria I

containing pl-asmids which have taken up DIIA I

i

cannot g rovr'.
C A radroaciively labelled gene lcrob"
containing a sinEle stranded iengch oi the
requiied Dli-q is used to bind to, and
ideniify Lhe DIIA- rn rhe pi,a.s:nicl insi,je r-he
baciei::a,
 77 02207 020 / 1APE /MS
/ 20(/7
aroLOcf
UNTT 02 - PAPER 02
T.{ARK SCTIEME 2OO7

Question 9 ( Cont ,d )
KC
(a) ( Cont,d) T'K

(ii) This is done by obta

Dacteria on a f i r*--tr-tl,n. a sample of the

.t"T#f ;,:i"d.l."t:ii"trffi 1,,:!

radi-oactivity.
The colony from lrhich
prepared is identifierthe. firtrate is
rsolated and cl'oned.
These bacteri.
gene. no"="=,o'
s the transplanted
8 points, of r{hich z
2 poiDts r[ust
each of .""ifl"t] be take! froI!
porDts - eigbt ,""n= tou c, and any other 2
(b) (i) The condition must be
di sorder due to a single gene
- A corrected ve of the gene must be
- rt must be ,rr"ttto' croned
ripo.o..tt"-'ruorPorated into a prasrnid or
- ft must be inc(
cerls by ,"=", '"tll||lto. i,nt: the aff ected./tarqer
-"o'=' rnhalation'
- tt is assumed . "n""ti"']'Iii.
sene beins ,;";:"T.:;:I.ffi: :;:T:;.):
- The new gene is n..t"r"ntiar ;ff. "";
scribed/a...
t ran rv
_ errectingr a ,cure,
As some treatednsrated
r,.'," io ;;'.';;."":.",1t:^":" trearrnents ,nay
"I.d, epitheli.i"".r'i=
rLtrq (e'g' shed
5 poi'ts - 5 rarks r
5
 18 02207 020 / C.APE / Lls / 20a7
BIOLOGY

UNIT 02 PAPER 02

MARI( SCHEME 2OO7

Question 9 ( cont 'd )

KC uI(i
(ii) cene therapy causes permanent changes to the
genome.
There is no control over the locus that the
transplanted genes will take up.
- t4any genes are controlled by epitasis
modifying grenes on other chromisomes or -

- Controls may be bypassed or rendered ineffective.

_ fn somatic cells,- e.g. epithelia, the life of the
treated cell may be short, therefore ,,OK,,.
_ Somatic ce1l treatment Lasts for just
l-ifetime of the individual who ma6e thefordecision
the
for genetic treatment.
- If germ ce11s are modified, future generations
may be affected indefinitely, perrnaientty.
- A cieficit or unexpecteci outcome will be inherited
for generations.
- A preferred/better treatment option may be
avai-Iable in the future than tire one a,r'ailable at
pres enl .
- Other suitable answer.
5poiats-5Earks 5

Specific Obj ectives: Modu1e 3 3.1, 3.2, 3.3 10 10