PHARMACOLOGY – SHORT QUIZZES BY L.A.T.

FIRST SHIFTING
BASIC PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY

SET 1
A. Pharmacokinetics
B. Pharmacovigilance
1 Genetic polymorphism known as SNIPs is studied in:
C. PHARMACOGENOMICS
D. Ethnopharmacology
A. TOLERANCE
B. Tachyphylaxis
2 Increasing the dose of the drug to produce the desired therapeutic effect is:
C. Potency
D. Efficacy
A. Tolerance
B. Tachyphylaxis
3 The minimum amount of drug needed to produce the desired therapeutic effect is:
C. POTENCY
D. Efficacy
A. Decarboxylation
B. Hydroxylation
4 G-protein coupled 2nd messengers undergo this reversible chemical process:
C. PHOSPHORYLATION
D. Dehydrogenation
A. Channel
B. Structural
5 α1, α2, β1, D1, and D2 are this type of receptors:
C. REGULATORY
D. Enzyme
A. Paracetamol
B. ASPIRIN
6 Analgesic-antipyretic-antithrombotic that produces ADRs as bleeding and hyperacidity is:
C. Diazepam
D. Chloroquine
A. COMPETITIVE
B. Noncompetitive
7 Morphine + naloxone produces this type of antagonism:
C. Physiologic
D. Chemical
A. 1+1=2
B. 1+0=0
8 Combination of drug that produces synergistic action is:
C. 1 + 1 = 11
D. 1 + 0 = >1
A. Paracetamol + ibuprofen
B. SMX + TRIMETHOPRIM
9 Example of the above #8 drug is:
C. Atropine + acetylcholine
D. Morphine + naloxone
A. CL
B. Vd
10 Rel over C is:
C. t1/2
D. T.I.
PHARMACOLOGY – SHORT QUIZZES BY L.A.T.

SET 2
A. CYP1
B. CYP2
1 The most common CYP-enzyme action of rational core drugs:
C. CYP3
D. CYP4
A. Vd (volume of distribution)
B. t1/2 (half-life)
2 0.7 Vd / CL =
C. 1st PE (first pass effect)
D. 1st OK (first order kinetics)
A. Wide
B. NARROW (≥10 is wide TI)
3 TI (therapeutic index) is 5. The safety of the drug is:
C. Full
D. Partial
A. Enzyme
Microtubule polymerization inhibitor is the MOA of antihelminthic drugs. What type of B. Regulatory
4
receptor does the drug belong to? C. Channel
D. STRUCTURAL
A. Gradual concentration
B. PEAK EFFECT
5 SSC (steady-state concentration) of the drug means:
C. Ultimate effect
D. Oscillating concentration
A. Changes the size
Minimal receptors and spare receptors are not advantageous in pharmacology principles. B. Change the form
6
What discovery must be done to this receptor for enhancement of effects of agonist. C. MODIFY THE BONDING
D. Different sizes
A. Methylation
What biotransformation does INH undergo that may lead to hepatotoxicity if the user is a B. Glutathione-conjugation
7
rapid acetylator? C. Glucuronidation
D. ACETYLATION
A. SLE
B. SJS
8 What is the most dreaded ADR of hydralazine, a vasodilator in HPN?
C. NMS
D. SS
A. Anaphylaxis
B. TACHYPHYLAXIS
9 Evanescent tolerance to a general anesthetic agent is:
C. Idiosyncrasy
D. Addiction
A. Enhanced drug action
B. Modulate drug action
10 Re-distribution phenomenon of drugs as thiopental Na+ will:
C. TERMINATE DRUG ACTION
D. Accelerate drug action