Unit 12 - DNA Worksheet - Structure of DNA and Replication

Eastern Intermediate High School Name:___________________________
Honors Biology Mod:______ Date:_________________
Unit 12 – DNA
Worksheet – Structure of DNA and Replication
Directions: Label the diagram below with the following choices:
 Nucleotide  Deoxyribose  Phosphate group

 Base pair  Hydrogen bond  Nitrogenous base
1. ____________________
6. ____________________ 2. ____________________
5. __________________
4. ____________________ 3. ____________________
1
Directions: Complete each sentence.
7. Guanine, cytosine, thymine, and __________________ are the four __________________
in DNA.
8. In DNA, guanine always forms hydrogen bonds with __________________.
9. The process of __________________ produces a new copy of an organism’s genetic

information, which is passed on to a new cell.
10. The double coiled, “staircase” shape of DNA is called a __________________.
Directions: Answer each question in complete sentences.

11. What do the letters DNA stand for?
_________________________________________________________________________
12. Where is DNA found? ____________________________________________________
13. Label the nucleotides (A, T, G, C) in the DNA molecule below:
14. What is the first step in the process of DNA replication?
2
15.What is the first step in the process of DNA replication?
_________________________________________________________________________
_________________________________________________________________________
16.Which enzyme is responsible for “unzipping” the DNA double helix?

_________________________________________________________________________
17. Which enzyme is responsible for facilitating the hydrogen bonding between nucleotides in
a new DNA molecule?
_________________________________________________________________________
_________________________________________________________________________
18.Which enzyme is responsible for creating the covalent bonds that connect the sugar-
phosphate backbone of the new DNA molecules?
_________________________________________________________________________
19. If the sequence of one single strand of DNA is C-A-A-G-T-A-G-G-C-T, what is the
sequence of the complementary strand?
_________________________________________________________________________
20. Describe the origin of each strand of the new double helices created after DNA
replication.
_________________________________________________________________________
_________________________________________________________________________
21. Why is DNA replication important to the growth and development of a multi-cellular
organism?
_________________________________________________________________________
_________________________________________________________________________
22. Place the following terms in the correct order from smallest to largest: Nucleosome,
supercoils, coils, chromosome, DNA double helix
_________________________________________________________________________
_________________________________________________________________________
23. List the 3 basic steps of DNA replication:

a. _________________________________________________________________
b. _________________________________________________________________
c. _________________________________________________________________
3
Original
24. The model of DNA below is ready to be copied. Compared to the A T
original double helix, evaluate the copies made during three attempts T A
of DNA replication. List any errors with the replication if they occurred: C G
C G
G C
Replication #1 T A
List problems if any:
A T A T G C
_______________________
T A T A
_______________________
C G C G
_______________________
C G AND A G _______________________
G C G C _______________________
T A T A _______________________
G C G C
Replication #2
A T A T List problems if any:
T A T A _______________________
C G C G _______________________
C G AND C G _______________________
G C G C _______________________
T A T A _______________________
G C G C _______________________
25.Complete the diagram on the left. Then circle the areas in the diagram on the right that
show a genetic mutation.
DNA Correctly Copied DNA Incorrectly Copied
G T
G C
C G
T A
A T
C A
A T
26. Explain how the mutations might have been caused in the diagram above.
_________________________________________________________________________
_________________________________________________________________________
_________________________________________________________________________

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What are nucleotides and what are they composed of?

What is the shape of DNA called and what does it resemble?

Eastern Intermediate High School Name:___________________________

Honors Biology Mod: Date:___________

Directions: Label the diagram below with the following choices:

 Nucleotide  Deoxyribose  Phosphate group

8. In DNA, guanine always forms hydrogen bonds with __________________.

9. The process of __________________ produces a new copy of an organism’s genetic

10. The double coiled, “staircase” shape of DNA is called a __________________.

Directions: Answer each question in complete sentences.

12. Where is DNA found? ____________________________________________________

13. Label the nucleotides (A, T, G, C) in the DNA molecule below:

14. What is the first step in the process of DNA replication?

16.Which enzyme is responsible for “unzipping” the DNA double helix?

23. List the 3 basic steps of DNA replication:

DNA Correctly Copied DNA Incorrectly Copied

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