The Pathogenesis of Fever

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Curriculum Vitae

Nama : Dr. Ronald Irwanto Natadidjaja, SpPD – KPTI, FINASIM

Pendidikan :
SMP - SMA : Kolese KANISIUS, lulus 1994
Dokter Umum : FK TRISAKTI, lulus 2002
Spesialis Penyakit Dalam (Internist) : FKUI, lulus 2009
Konsultan / Subspesialis Penyakit Tropik & Infeksi : FKUI / PAPDI, lulus 2013

Pekerjaan :
Bendahara Pengurus Besar Perhimpunan Konsultan Penyakit Tropik dan Infeksi
Indonesia (PB PETRI)

SekJen Pengurus Pusat Perhimpunan Pengendalian Infeksi Indonesia (PP. PERDALIN)

Tim Panel Ahli PNPK Sepsis, Kemenkes RI

Anggota Pokja PPI, Kemenkes RI

Kepala Bagian Ilmu Penyakit Dalam, FK TRISAKTI

Ketua PPRA, RS PONDOK INDAH – PURI INDAH dan RS PONDOK INDAH – BINTARO JAYA

Internist - Konsultan, RS PONDOK INDAH – PURI INDAH dan RS PONDOK INDAH –


BINTARO JAYA

Tim Pengendalian COVID-19, RS PONDOK INDAH – PURI INDAH dan RS PONDOK INDAH
– BINTARO JAYA
The Pathogenesis
of Fever
Ronald Irwanto

Division of Tropical Medicine and Infectious Disease


Department of Internal Medicine
Trisakti School of Medicine
FEVER

► The symptom of disease which frequently


encountered
► It has been known since the ancient time
► Complaints which often expressed
► Guide for the development of disease
► Rapid onset
► Sometimes cause the interference / malaise
FEVER

► Thecomplex physiological reaction of


disease and is characterized by the increase
of body temperature above normal due to
pyrogen as excitatory substances on body
temperature regulator in the hypothalamus.
Body Temperature Control

Source of Energy Energy Consumption

Internal
Work Energy
Metabolic pool (Heat)
Food
in the body External
Work

Energy
Storage
SKIN TEMP. BODY CORE TEMP.

PERIPHERAL THERMORECEPTOR CENTRAL THERMORECEPTOR ( HYPOTHALAMUS,


(SKIN) CNS, ABDOMINAL ORGAN )

CENTRAL THERMOREGULATION
HYPOTHALAMUS

ADAPTATION OF MOTORIC NERVE SYMPATHETIC SYMPATHETIC


BEHAVIOUR NERVE SYSTEM NERVE SYSTEM

SKELETAL MUSCLE BLOOD VESSEL OF APOCRINE


SKIN

VASOCONSTRICTION & SWEATING


MUSCLE TONE,
VASODILATATION OF SKIN
SHIVERING

HEAT
PRODUCTION/RELEASE HEAT HEAT RELEASE HEAT RELEASE
REGULATOR PRODUCTION REGULATOR REGULATOR
REGULATOR
THE PATHOPHYSIOLOGY OF
FEVER

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