Heredity - Wikipedia
Heredity - Wikipedia
Heredity - Wikipedia
Heredity
Heredity, also called inheritance or biological inheritance, is the passing on of traits from
parents to their offspring; either through asexual reproduction or sexual reproduction, the
offspring cells or organisms acquire the genetic information of their parents. Through heredity,
variations between individuals can accumulate and cause species to evolve by natural selection.
The study of heredity in biology is genetics.
Contents
Overview
Relation to theory of evolution
History
Gregor Mendel: father of genetics
Modern development of genetics and heredity
Common genetic disorders
Types
Dominant and recessive alleles
See also
References
External links
Overview
In humans, eye color is an example of an inherited characteristic: an
individual might inherit the "brown-eye trait" from one of the parents.[1]
Inherited traits are controlled by genes and the complete set of genes
within an organism's genome is called its genotype.[2]
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Recent findings have confirmed important examples of heritable changes that cannot be explained
by direct agency of the DNA molecule. These phenomena are classed as epigenetic inheritance
systems that are causally or independently evolving over genes. Research into modes and
mechanisms of epigenetic inheritance is still in its scientific infancy, however, this area of research
has attracted much recent activity as it broadens the scope of heritability and evolutionary biology
in general.[12] DNA methylation marking chromatin, self-sustaining metabolic loops, gene
silencing by RNA interference, and the three dimensional conformation of proteins (such as
prions) are areas where epigenetic inheritance systems have been discovered at the organismic
level.[13][14] Heritability may also occur at even larger scales. For example, ecological inheritance
through the process of niche construction is defined by the regular and repeated activities of
organisms in their environment. This generates a legacy of effect that modifies and feeds back into
the selection regime of subsequent generations. Descendants inherit genes plus environmental
characteristics generated by the ecological actions of ancestors.[15] Other examples of heritability
in evolution that are not under the direct control of genes include the inheritance of cultural traits,
group heritability, and symbiogenesis.[16][17][18] These examples of heritability that operate above
the gene are covered broadly under the title of multilevel or hierarchical selection, which has been
a subject of intense debate in the history of evolutionary science.[17][19]
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Darwin's initial model of heredity was adopted by, and then heavily modified by, his cousin
Francis Galton, who laid the framework for the biometric school of heredity.[23] Galton found no
evidence to support the aspects of Darwin's pangenesis model, which relied on acquired traits.[24]
The inheritance of acquired traits was shown to have little basis in the 1880s when August
Weismann cut the tails off many generations of mice and found that their offspring continued to
develop tails.[25]
History
Scientists in Antiquity had a variety of ideas
about heredity: Theophrastus proposed that male
flowers caused female flowers to ripen;[26]
Hippocrates speculated that "seeds" were
produced by various body parts and transmitted
to offspring at the time of conception;[27] and
Aristotle thought that male and female fluids
mixed at conception.[28] Aeschylus, in 458 BC,
proposed the male as the parent, with the female
as a "nurse for the young life sown within
her".[29]
During the 18th century, Dutch microscopist Antonie van Leeuwenhoek (1632–1723) discovered
"animalcules" in the sperm of humans and other animals.[30] Some scientists speculated they saw
a "little man" (homunculus) inside each sperm. These scientists formed a school of thought known
as the "spermists". They contended the only contributions of the female to the next generation
were the womb in which the homunculus grew, and prenatal influences of the womb.[31] An
opposing school of thought, the ovists, believed that the future human was in the egg, and that
sperm merely stimulated the growth of the egg. Ovists thought women carried eggs containing boy
and girl children, and that the gender of the offspring was determined well before conception.[32]
An early research initiative emerged in 1878 when Alpheus Hyatt led an investigation to study the
laws of heredity through compiling data on family phenotypes (nose size, ear shape, etc.) and
expression of pathological conditions and abnormal characteristics, particularly with respect to the
age of appearance. One of the projects aims was to tabulate data to better understand why certain
traits are consistently expressed while others are highly irregular.[33]
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1. All evolutionary phenomena can be explained in a way consistent with known genetic
mechanisms and the observational evidence of naturalists.
2. Evolution is gradual: small genetic changes, recombination ordered by natural selection.
Discontinuities amongst species (or other taxa) are explained as originating gradually through
geographical separation and extinction (not saltation).
3. Selection is overwhelmingly the main mechanism of change; even slight advantages are
important when continued. The object of selection is the phenotype in its surrounding
environment. The role of genetic drift is equivocal; though strongly supported initially by
Dobzhansky, it was downgraded later as results from ecological genetics were obtained.
4. The primacy of population thinking: the genetic diversity carried in natural populations is a key
factor in evolution. The strength of natural selection in the wild was greater than expected; the
effect of ecological factors such as niche occupation and the significance of barriers to gene
flow are all important.
The idea that speciation occurs after populations are reproductively isolated has been much
debated.[38] In plants, polyploidy must be included in any view of speciation. Formulations such as
'evolution consists primarily of changes in the frequencies of alleles between one generation and
another' were proposed rather later. The traditional view is that developmental biology ('evo-
devo') played little part in the synthesis, but an account of Gavin de Beer's work by Stephen Jay
Gould suggests he may be an exception.[39]
Almost all aspects of the synthesis have been challenged at times, with varying degrees of success.
There is no doubt, however, that the synthesis was a great landmark in evolutionary biology.[40] It
cleared up many confusions, and was directly responsible for stimulating a great deal of research
in the post-World War II era.
Trofim Lysenko however caused a backlash of what is now called Lysenkoism in the Soviet Union
when he emphasised Lamarckian ideas on the inheritance of acquired traits. This movement
affected agricultural research and led to food shortages in the 1960s and seriously affected the
USSR.[41]
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Fragile X syndrome
Sickle cell disease
Phenylketonuria (PKU)
Haemophilia[35]
Types
The description of a mode of biological inheritance consists of
three main categories:
3. Correlation genotype–phenotype
An example pedigree chart of an
Dominant autosomal recessive disorder.
Intermediate (also called "codominant")
Recessive
Overdominant
Underdominant
Invariable
Variable
Heritability (in polygenetic and sometimes also in oligogenetic modes of inheritance)
Maternal or paternal imprinting phenomena (also see epigenetics)
5. Sex-linked interactions
6. Locus–locus interactions
Epistasis with other loci (e.g., overdominance)
Gene coupling with other loci (also see crossing over)
Homozygotous lethal factors
Semi-lethal factors
See also
Hard inheritance
Lamarckism
Heritability
Particulate inheritance
Non-Mendelian inheritance
Extranuclear inheritance
Uniparental inheritance
Epigenetic inheritance
Transgenerational epigenetics#Major controversies in the history of inheritance
Inheritance of acquired characteristics
Structural inheritance
Blending inheritance
References
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External links
Stanford Encyclopedia of Philosophy entry on Heredity and Heritability (http://plato.stanford.ed
u/entries/heredity/)
""Experiments in Plant Hybridization" (1866), by Johann Gregor Mendel," by A. Andrei at the
Embryo Project Encyclopedia (http://embryo.asu.edu/pages/experiments-plant-hybridization-1
866-johann-gregor-mendel)
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