Drug Study Losartan

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Name of the Mechanism of Action Dosage Indication Contraindication Adverse Nursing Alert

Drug Reaction
LOSARTAN Losartan administration 50mg Hypertension Hypersensitivity CNS 1.Monitor BP
POTASSIUM results in a decrease in total BID Treatment of to losartan Dizziness, prior to the
peripheral resistance and hypertension, Use cautiously insomnia, administration
Classifications: cardiac venous return. All IV alone or in with hepatic or headache. of medication of
cardiovascular of the physiological effects combination renal GI: Diarrhea, scheduled dose
agent; of angiotensin II, including with other dysfunction, dyspepsia. 2.Monitor drug
angiotensin stimulation of release antihypertensive hypovolemia Musculoskeletal: for effectiveness
receptor of aldosterone, are Agents. Muscle cramps, 3. If there is
antagonized in the presence Treatment of myalgia, back or inadequate
antagonist;
of losartan. Reduction in diabetic leg pain. response split
antihypertensive blood pressure occurs neuropathy with Respiratory: the daily dose in
independently of the status Nasal a day is into
an elevated
of the renin-angiotensin congestion, twice daily is
system. As a result of serum recommended
cough, upper
losartan dosing, plasma creatinine and 4. Lab tests:
respiratory
renin. Activity increases proteinuria in infection, Monitor CBC,
due to removal of the patients with sinusitis electrolytes,
angiotensin II feedback. type 2 diabetes liver & kidney
Selectively blocks the and a history function with
binding of angiotensin II to long-term
of hypertension
specific tissue receptors therapy.
found in the vascular 5. Inform client
smooth muscle and adrenal to not stop
gland; this action blocks the taking this drug
vasoconstriction effect of without doctors
the renin-angiotensin order
system as well as the release 6.  Report fever,
of aldosterone leading to chills, dizziness
decreased blood pressure.

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