Comprehensive Medicinal Chemistry: Corwin Hansch

COMPREHENSIVE
MEDICINAL CHEMISTRY
The Rational Design, Mechanistic Study & Therapeutic
Application of Chemical Compounds
Chairman of the Editorial Board

CORWIN HANSCH
Pomona College, Claremont, CA, USA
Joint Executive Editors

PETER G. SAMMES
Brunei University of West London, Uxbridge, UK
JOHN B. TAYLOR
Rhone-Poulenc Ltd, Dagenham, UK
Volume 6
CUMULATIVE SUBJECT INDEX &
DRUG COMPENDIUM
Volume Editor
COLIN J. DRAYTON
Pergamon Press, Oxford, UK
PERGAMON PRESS
Member of Maxwell Macmillan Pergamon Publishing Corporation
OXFORD • NEW YORK • BEIJING • FRANKFURT
SAO PAULO • SYDNEY • TOKYO • TORONTO
Contents of All Volumes
Volume 1 General Principles
Historical Perspective
1.1 Medicinal Chemistry: A Personal View

1.2 Chronology of Drug Introductions
1.3 Evolution of the Pharmaceutical Industry
1.4 Development of Medicinal Chemistry in China
1.5 Contribution of Ayurvedic Medicine to Medicinal Chemistry
Targets of Biologically Active Molecules
2.1 Physiology of the Human Body

2.2 The Architecture of the Cell
2.3 Macromolecular Targets for Drug Action
2.4 The Concept of Bioselectivity
2.5 The Immune System
2.6 Selectivity
Bioactive Materials
3.1 Classification of Drugs

3.2 Lead Structure Discovery and Development
3.3 Computer-aided Selection for Large-scale Screening
3.4 Isolation of Bioactive Materials and Assay Methods
3.5 Biomaterials from Mammalian Sources
3.6 Development and Scale-up of Processes for the Manufacture of New Pharmaceuticals
3.7 Genetic Engineering: The Gene '•
3.8 Genetic Engineering: Applications to Biological Research
3.9 Genetic Engineering: Commercial Applications
Socio-economic Factors of Drug Development
4.1 Industrial Factors and Government Controls

4.2 Organization and Funding of Medical Research in the UK
4.3 Organization and Funding of Medical Research in the USA
4.4 Health Care in the UK
4.5 Health Care in the USA
4.6 Good Pharmaceutical Manufacturing Practice
4.7 Toxicological Evaluation of New Drugs
4.8 Clinical Pharmacology and Clinical Trials
4.9 Post-marketing Surveillance
4.10 Animal Experimentation
4.11 Orphan Drugs
4.12 Patents
4.13 Trade Marks
4.14 Sources of Information
Subject Index
XI
xii Contents of All Volumes
Volume 2 Enzymes and Other Molecular Targets
Enzymes
5.1 Enzyme Structure

5.2 Nomenclature and Classification of Enzymes
5.3 Enzyme Catalysis
5.4 Enzyme Inhibition
5.5 Resistance and Tolerance to Antimicrobial Drugs
Agents Acting on Oxygenases, Electron Transport Systems and Pyridoxal Dependent Systems
6.1 Oxygenases
6.2 The Arachidonic Acid Cascade
6.3 Agents Acting on Passive Ion Transport
6.4 Agents Acting on Active Ion Transport
6.5 Pyridoxal Dependent Systems
Agents Acting on Metabolic Processes
7.1 Sulfonamides and Sulfones

7.2 Reductases
7.3 Purine and Pyrimidine Targets
7.4 Therapeutic Consequences of the Inhibition of Sterol Metabolism
Agents Acting on Hydrolases and Peptidases
8.1 Hydrolases
8.2 Peptidase Inhibitors
8.3 Enzyme Cascades: Purine Metabolism and Immunosuppression
8.4 Enzyme Cascades: Coagulation, Fibrinolysis and Hemostasis
8.5 Selective Inhibitors of Phosphodiesterases
8.6 Agents Acting Against Phospholipases A2
8.7 Protein Kinases
Agents Acting on Cell Walls
9.1 Cell Wall Structure and Function

9.2 p-Lactam Antibiotics: Penicillins and Cephalosporins
9.3 Other P-Lactam Antibiotics
Agents Acting on Nucleic Acids
10.1 DNA Intercalating Agents

10.2 DNA Binding and Nicking Agents
10.3 Agents Interfering with DNA Enzymes
10.4 Inhibitors of the Transcribing Enzymes: Rifamycins and Related Agents
10.5 Agents which Interact with Ribosomal RNA and Interfere with its Functions
Subject Index
Contents of All Volumes xiii
Volume 3 Membranes and Receptors
Membranes, Membrane Receptors and Second Messenger Pathways
11.1 Structure and Function of Cell Membranes

11.2 Quantitative Analysis of Ligand-Receptor Interactions
11.3 Isolation, Purification and Molecular Biology of Cell Membrane Receptors
11.4 Transduction Signalling, Second Messenger Analogues and Inositol Phosphates
Neurotransmitter and Autocoid Receptors
12.1 a-Adrenergic Receptors

12.2 P-Adrenergic Receptors
12.3 Dopamine Receptors
12.4 Peripheral Dopamine Receptors
12.5 Histamine Receptors
12.6 Cholinergic Receptors
12.7 Amino Acid Receptors
12.8 Ligand Interactions at the Benzodiazepine Receptor
12.9 Serotonin (5-HT) Receptors
12.10 Adenosine (P,) and ATP (P2) Receptors
12.11 Prostanoid Receptors
12.12 Platelet Activating Factor Receptors
12.13 Leukotriene Receptors
Peptidergic Receptors
13.1 Design of Drugs Acting at Peptidergic Receptors

13.2 Opioid Receptors
13.3 Hypothalamic and Adenohypophyseal Hormone Receptors
13.4 Neurohypophyseal Hormone Receptors
13.5 Glucagon and Insulin Receptors
13.6 Gastrointestinal Regulatory Peptide Receptors
13.7 Angiotensin and Bradykinin Receptors
13.8 Atrial Natriuretic Factor Receptors
13.9 Tachykinin Receptors
13.10 Calcitonin and Parathyroid Hormone Receptors
Drugs Acting on Ion Channels and Membranes
14.1 Drugs Acting on Ion Channels and Membranes
Lymphokines and Cytokines
15.1 Lymphokines and Cytokines of the Immune System
Intracellular Receptors
16.1 Molecular Mechanism of the Action of 1,25-Dihydroxyvitamin D3

16.2 Thyroid Hormone Receptors
16.3 Steroid Hormone Receptors
Subject Index
Xlv
Volume 4 Quantitative Drug Design
Introduction to Drug Design and Molecular Modelling
17.1" History and Objectives of Quantitative Drug Design

17.2 Computers and the Medicinal Chemist
17.3 Chemical Structures and Computers
17.4 Use and Limitations of Models and Modelling in Medicinal Chemistry
Quantitative Description of Physicochemical Properties of Drug Molecules
18.1 Quantum Mechanics and the Modeling of Drug Properties

18.2 Molecular Mechanics and the Modeling of Drug Structures
18.3 Dynamic Simulation and its Applications in Drug Research
18.4 Three-dimensional Structure of Drugs
18.5 Electronic Effects in Drugs
18.6 Hydrophobic Properties of Drugs
18.7 Methods of Calculating Partition Coefficients
18.8 Intermolecular Forces and Molecular Binding
Quantitative Description of Biological Activity and Drug Transport
19.1 Quantitative Description of Biological Activity
19.2 Molecular Structure and Drug Transport
Molecular Graphics and Drug Design
20.1 Introduction to Computer Graphics and Its Use for Displaying Molecular Structures
20.2 Use of Molecular Graphics for Structural Analysis of Small Molecules
20.3 Application of Molecular Graphics to the Analysis of Macromolecular Structures
Quantitative Structure-Activity Relationships
21.1 The Extrathermodynamic Approach to Drug Design

21.2 The Design of Test Series and the Significance of QSAR Relationships
21.3 The Free-Wilson Method and its Relationship to the Extrathermodynamic Approach
Pattern Recognition and Other Statistical Methods for Drug Design
22.1 Substructural Analysis and Compound Selection

22.2 Linear Discriminant Analysis and Cluster Significance Analysis
22.3 Pattern Recognition Techniques in Drug Design
22.4 The Distance Geometry Approach to Modeling Receptor Sites
Subject Index
Volume 5 Biopharmaceutics
Principles of Pharmacokinetics and Metabolism
23.1 Absorption Processes

23.2 Pharmacokinetic Aspects of Drug Administration and Metabolism
23.3 Distribution and Clearance Concepts
23.4 Sites of Drug Metabolism, Prodrugs and Bioactivation
23.5 Metabolic Pathways
xv
23.6 Drug Interactions
23.7 Stereoselectivity in Pharmacokinetics and Drug Metabolism
23.8 Enzyme Induction and Inhibition
23.9 Species Differences in Drug Metabolism
23.10 Developmental Drug Metabolism
23.11 Pharmacogenetics
23.12 Chronokinetics
23.13 Population Pharmacokinetics
23.14 Toxicokinetics
23.15 Pharmacodynamics
Analytical Methodology
24.1 Use of Isotopes in Quantitative and Qualitative Analysis

24.2 Chemical Analysis
24.3 Biological Analysis
24.4 Methods in Drug Metabolism
24.5 Isolation and Identification of Metabolites
24.6 Systems Analysis in Pharmacokinetics
Chemistry and Pharmacy in Drug Development
25.1 Physicochemical Principles

25.2 Formulation
25.3 Routes of Administration and Dosage Regimes
25.4 Delivery System Technology
25.5 Drug Targeting
Subject Index
Volume 6
Cumulative Subject Index
Drug Compendium

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COMPREHENSIVE

Chairman of the Editorial Board

Joint Executive Editors

1.1 Medicinal Chemistry: A Personal View

Targets of Biologically Active Molecules

2.1 Physiology of the Human Body

3.1 Classification of Drugs

Socio-economic Factors of Drug Development

4.1 Industrial Factors and Government Controls

Volume 2 Enzymes and Other Molecular Targets

5.1 Enzyme Structure

Agents Acting on Metabolic Processes

7.1 Sulfonamides and Sulfones

Agents Acting on Hydrolases and Peptidases

Agents Acting on Cell Walls

9.1 Cell Wall Structure and Function

Agents Acting on Nucleic Acids

10.1 DNA Intercalating Agents

Volume 3 Membranes and Receptors

Membranes, Membrane Receptors and Second Messenger Pathways

11.1 Structure and Function of Cell Membranes

Neurotransmitter and Autocoid Receptors

12.1 a-Adrenergic Receptors

13.1 Design of Drugs Acting at Peptidergic Receptors

Drugs Acting on Ion Channels and Membranes

14.1 Drugs Acting on Ion Channels and Membranes

Lymphokines and Cytokines

15.1 Lymphokines and Cytokines of the Immune System

16.1 Molecular Mechanism of the Action of 1,25-Dihydroxyvitamin D3

Volume 4 Quantitative Drug Design

Introduction to Drug Design and Molecular Modelling

17.1" History and Objectives of Quantitative Drug Design

Quantitative Description of Physicochemical Properties of Drug Molecules

18.1 Quantum Mechanics and the Modeling of Drug Properties

Quantitative Description of Biological Activity and Drug Transport

19.1 Quantitative Description of Biological Activity

19.2 Molecular Structure and Drug Transport

Molecular Graphics and Drug Design

20.3 Application of Molecular Graphics to the Analysis of Macromolecular Structures

Quantitative Structure-Activity Relationships

21.1 The Extrathermodynamic Approach to Drug Design

Pattern Recognition and Other Statistical Methods for Drug Design

22.1 Substructural Analysis and Compound Selection

Principles of Pharmacokinetics and Metabolism

23.1 Absorption Processes

24.1 Use of Isotopes in Quantitative and Qualitative Analysis

Chemistry and Pharmacy in Drug Development

25.1 Physicochemical Principles

25.5 Drug Targeting

Cumulative Subject Index

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