Safety Data Sheet

Dow Chemical Company Ltd

Safety Data Sheet according to Reg. (EC) N. 453/2010

Product Name: CELLOSIZE (TM) HYDROXYETHYL CELLULOSE Revision Date: 2012/08/27

QP-100 MH Europe
Print Date: 14 Mar 2014

Dow Chemical Company Ltd encourages and expects you to read and understand the entire (M)SDS,
as there is important information throughout the document. We expect you to follow the precautions
identified in this document unless your use conditions would necessitate other appropriate methods or
actions.

Section 1. Identification of the substance/preparation and of the

company/undertaking
1.1 Product identifiers
Product Name
CELLOSIZE ™ HYDROXYETHYL CELLULOSE QP-100 MH Europe

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses
Thickener. Film former. Stabiliser. Protective colloid. Binder. We recommend that you use this
product in a manner consistent with the listed use. If your intended use is not consistent with the stated
use, please contact your sales or technical service representative.

1.3 Details of the supplier of the safety data sheet

COMPANY IDENTIFICATION
Dow Chemical Company Ltd
Diamond House, Lotus Park
Kingsbury Crescent
TW18 3AG Staines, Middlesex
United Kingdom

Customer Information Number: 0203 139 4000

[email protected]

1.4 EMERGENCY TELEPHONE NUMBER

24-Hour Emergency Contact: 0031 115 694 982
Local Emergency Contact: 00 31 115 69 4982

Section 2. Hazards Identification

2.1 Classification of the substance or mixture

Classification according to EU Directives 67/548/EEC or 1999/45/EC

This product is not classified as dangerous according to EC criteria.

2.2 Label elements

®(TM)*Trademark

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Product Name: CELLOSIZE (TM) HYDROXYETHYL CELLULOSE Revision Date: 2012/08/27
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Labelling according to EC Directives

This product is not classified as dangerous according to EC criteria.

Safety data sheet available for professional users on request.

2.3 Other Hazards

No information available.

Section 3. Composition/information on ingredients

3.2 Mixture
This product is a mixture.
CAS-No. / EC-No. / REACH No. Amount Component Classification:
Index REGULATION (EC)
No 1272/2008
CAS-No. — >= 86.0 % Hydroxyethyl Not classified
9004-62-0 cellulose##
EC-No.
Polymer

CAS-No. — <= 7.5 % Sodium acetate## Not classified

127-09-3
EC-No.
204-823-8

CAS-No. — <= 5.0 % Water## Not classified

7732-18-5
EC-No.
231-791-2

CAS-No. — <= 3.0 % Propan-2-ol; Flam. Liq., 2, H225

67-63-0 isopropyl alcohol; Eye Irrit., 2, H319
EC-No. isopropanol STOT SE, 3, H336
200-661-7
Index
603-117-00-0
CAS-No. — <= 1.5 % Cellulose# Not classified
9004-34-6
EC-No.
232-674-9

CAS-No. / EC-No. / Amount Component Classification:

Index 67/548/EEC
CAS-No. >= 86.0 % Hydroxyethyl Not classified.
9004-62-0 cellulose##
EC-No.
Polymer

CAS-No. <= 7.5 % Sodium acetate## Not classified.

127-09-3
EC-No.
204-823-8

CAS-No. <= 5.0 % Water## Not classified.

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Product Name: CELLOSIZE (TM) HYDROXYETHYL CELLULOSE Revision Date: 2012/08/27
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7732-18-5
EC-No.
231-791-2

CAS-No. <= 3.0 % Propan-2-ol; isopropyl F: R11; Xi: R36; R67

67-63-0 alcohol; isopropanol
EC-No.
200-661-7
Index
603-117-00-0
CAS-No. <= 1.5 % Cellulose# Not classified.
9004-34-6
EC-No.
232-674-9

# Substance(s) with an Occupational Exposure Limit.

## Voluntarily disclosed component(s).
For the full text of the H-Statements mentioned in this Section, see Section 16.
See Section 16 for full text of R-phrases.

Section 4. First-aid measures

4.1 Description of first aid measures

General advice: First Aid responders should pay attention to self-protection and use the
recommended protective clothing (chemical resistant gloves, splash protection). If potential for
exposure exists refer to Section 8 for specific personal protective equipment.
Inhalation: Move person to fresh air. If not breathing, give artificial respiration; if by mouth to mouth
use rescuer protection (pocket mask, etc). If breathing is difficult, oxygen should be administered by
qualified personnel. Call a physician or transport to a medical facility.
Skin Contact: Wash skin with plenty of water.
Eye Contact: Flush eyes thoroughly with water for several minutes. Remove contact lenses after the
initial 1-2 minutes and continue flushing for several additional minutes. If effects occur, consult a
physician, preferably an ophthalmologist.
Ingestion: No emergency medical treatment necessary.
4.2 Most important symptoms and effects, both acute and delayed
Aside from the information found under Description of first aid measures (above) and Indication of
immediate medical attention and special treatment needed (below), no additional symptoms and
effects are anticipated.
4.3 Indication of immediate medical attention and special treatment needed
Maintain adequate ventilation and oxygenation of the patient. Hemodialysis may be of benefit if
substantial amounts have been ingested and the patient is showing signs of intoxication. Consider
hemodialysis for patients with persistent hypotension or coma unresponsive to standard therapy
(isopropanol levels >400 - 500 mg/dl). (Goldfrank 1998, King et al, 1970). No specific antidote.
Treatment of exposure should be directed at the control of symptoms and the clinical condition of the
patient.

Section 5. Fire Fighting Measures

5.1 Extinguishing Media

Water. Dry chemical fire extinguishers. Carbon dioxide fire extinguishers.

5.2 Special hazards arising from the substance or mixture

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Hazardous Combustion Products: During a fire, smoke may contain the original material in addition
to combustion products of varying composition which may be toxic and/or irritating. Combustion
products may include and are not limited to: Carbon monoxide. Carbon dioxide.
Unusual Fire and Explosion Hazards: Do not permit dust to accumulate. When suspended in air
dust can pose an explosion hazard. Minimize ignition sources. If dust layers are exposed to elevated
temperatures, spontaneous combustion may occur. Pneumatic conveying and other mechanical
handling operations can generate combustible dust. To reduce the potential for dust explosions,
electrically bond and ground equipment and do not permit dust to accumulate. Dust can be ignited by
static discharge.
5.3 Advice for firefighters
Fire Fighting Procedures: Keep people away. Isolate fire and deny unnecessary entry. Soak
thoroughly with water to cool and prevent re-ignition. Cool surroundings with water to localize fire
zone. Hand held dry chemical or carbon dioxide extinguishers may be used for small fires. Dust
explosion hazard may result from forceful application of fire extinguishing agents.
Special Protective Equipment for Firefighters: Wear positive-pressure self-contained breathing
apparatus (SCBA) and protective fire fighting clothing (includes fire fighting helmet, coat, trousers,
boots, and gloves). If protective equipment is not available or not used, fight fire from a protected
location or safe distance.

Section 6. Accidental Release Measures

6.1 Personal precautions, protective equipment and emergency procedures: Material becomes
slippery when wet. Use appropriate safety equipment. For additional information, refer to Section 8,
Exposure Controls and Personal Protection.

6.2 Environmental precautions: Prevent from entering into soil, ditches, sewers, waterways and/or
groundwater. See Section 12, Ecological Information.
6.3 Methods and materials for containment and cleaning up: Sweep up. Use care to minimize
generation of airborne dust. Do not use water for cleanup. Collect in suitable and properly labeled
containers. See Section 13, Disposal Considerations, for additional information.

Section 7. Handling and Storage

7.1 Precautions for safe handling

Handling
General Handling: Avoid contact with eyes. Wash thoroughly after handling. Good housekeeping
and controlling of dusts are necessary for safe handling of product. No smoking, open flames or
sources of ignition in handling and storage area. Electrically bond and ground all containers,
personnel and equipment before transfer or use of material. Keep away from heat, sparks and flame.
Powdered material may form explosive dust-air mixture. Keep container closed. Buildup of
flammable/air mixtures is possible without adequate ventilation. Use only in well ventilated area.
Ventilate shipping container before entering. See Section 8, EXPOSURE CONTROLS AND
PERSONAL PROTECTION.

7.2 Conditions for safe storage, including any incompatibilities

Storage
Store in a dry place. Protect from atmospheric moisture. Store in a well-ventilated place.
Shelf life: Use within 36 Months

7.3 Specific end uses

See the technical data sheet on this product for further information.

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Section 8. Exposure Controls / Personal Protection

8.1 Control parameters
Exposure Limits
Component List Type Value
|

Propan-2-ol; isopropyl UK WEL TWA 999 mg/m3 400 ppm

alcohol; isopropanol
UK WEL STEL 1,250 mg/m3 500 ppm
ACGIH TWA 200 ppm BEI
ACGIH STEL 400 ppm BEI
Ireland OELV TWA 200 ppm SKIN
Ireland OELV STEL 400 ppm SKIN
||

Cellulose Ireland OELV TWA 4 mg/m3

Respirable
dust.
Ireland OELV TWA Total 10 mg/m3
inhalable
dust.
Ireland OELV STEL Total 20 mg/m3
inhalable
dust.
ACGIH TWA 10 mg/m3
UK WEL TWA 10 mg/m3
Inhalable
dust.
UK WEL TWA 4 mg/m3
Respirable
dust.
UK WEL STEL 20 mg/m3
Inhalable
dust.

A BEI notation following the exposure guideline refers to a guidance value for assessing biological
monitoring results as an indicator of the uptake of a substance from all routes of exposures.
A “skin” notation following the inhalation exposure guideline refers to the potential for dermal
absorption of the material including mucous membranes and the eyes either by contact with vapors or
by direct skin contact.
It is intended to alert the reader that inhalation may not be the only route of exposure and that
measures to minimize dermal exposures should be considered.

8.2 Exposure controls

Personal Protection
Eye/Face Protection: Use safety glasses (with side shields). Safety glasses (with side shields)
should be consistent with EN 166 or equivalent. If there is a potential for exposure to particles which
could cause eye discomfort, wear chemical goggles. Chemical goggles should be consistent with EN
166 or equivalent.
Skin Protection: No precautions other than clean body-covering clothing should be needed.
Hand protection: Chemical protective gloves should not be needed when handling this
material. Consistent with general hygienic practice for any material, skin contact should be
minimized.
Respiratory Protection: Atmospheric levels should be maintained below the exposure guideline.
When respiratory protection is required, use an approved air-purifying or positive-pressure supplied-air
respirator depending on the potential airborne concentration. For emergency and other conditions
where the exposure guideline may be exceeded, use an approved positive-pressure self-contained
breathing apparatus or positive-pressure air line with auxiliary self-contained air supply. In confined or
poorly ventilated areas, use an approved self-contained breathing apparatus or positive pressure air
line with auxiliary self-contained air supply. Use the following CE approved air-purifying respirator:
Organic vapor cartridge with a particulate pre-filter, type AP2.
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Ingestion: Use good personal hygiene. Do not consume or store food in the work area. Wash hands
before smoking or eating.
Engineering Controls
Ventilation: Use local exhaust ventilation, or other engineering controls to maintain airborne levels
below exposure limit requirements or guidelines. If there are no applicable exposure limit
requirements or guidelines, general ventilation should be sufficient for most operations. Local exhaust
ventilation may be necessary for some operations.

Section 9. Physical and Chemical Properties

9.1 Information on basic physical and chemical properties
Appearance
Physical State Powder
Color White
Odor Mild
Odor Threshold No test data available
pH Not applicable
Melting Point No test data available
Freezing Point Not applicable
Boiling Point (760 mmHg) Not applicable.
Flash Point - Closed Cup No test data available
Evaporation Rate (Butyl No test data available
Acetate = 1)
Flammability (solid, gas) No
Flammable Limits In Air Lower: No test data available
Upper: No test data available
Vapor Pressure Not applicable
Vapor Density (air = 1) Not applicable
Specific Gravity (H2O = 1) 1.30 - 1.40 Literature
Solubility in water (by completely miscible with water
weight)
Partition coefficient, n- No data available for this product.
octanol/water (log Pow)
Autoignition Temperature > 400 °C Literature
Decomposition No test data available
Temperature
Kinematic Viscosity Not applicable
Explosive properties no data available
Oxidizing properties no data available

9.2 Other information

Section 10. Stability and Reactivity

10.1 Reactivity
No dangerous reaction known under conditions of normal use.
10.2 Chemical stability
Thermally stable at typical use temperatures. Hygroscopic.

10.3 Possibility of hazardous reactions

Polymerization will not occur.
10.4 Conditions to Avoid: Avoid temperatures above 200°C (392°F) Exposure to elevated
temperatures can cause product to decompose. Avoid static discharge. Avoid moisture.

10.5 Incompatible Materials: Avoid contact with oxidizing materials.

10.6 Hazardous decomposition products
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Decomposition products depend upon temperature, air supply and the presence of other materials.

Section 11. Toxicological Information

11.1 Information on toxicological effects
Acute Toxicity
Ingestion
Very low toxicity if swallowed. Harmful effects not anticipated from swallowing small amounts.
Swallowing may result in gastrointestinal irritation.
Single dose oral LD50 has not been determined.
For the major component(s): Estimated. LD50, rat > 8,700 mg/kg
Aspiration hazard
Based on physical properties, not likely to be an aspiration hazard.
Dermal
Prolonged skin contact is unlikely to result in absorption of harmful amounts.
The dermal LD50 has not been determined.
Inhalation
Dust may cause irritation to upper respiratory tract (nose and throat). Mist may cause irritation of
upper respiratory tract (nose and throat). Excessive exposure (400 ppm) to isopropanol may cause
eye, nose and throat irritation. Incoordination, confusion, hypotension, hypothermia, circulatory
collapse, respiratory arrest and death may follow a longer duration or higher levels. Observations in
animals include middle ear lining damage upon exposure to vapors of isopropanol. However, the
relevance of this to humans is unknown
As product: The LC50 has not been determined.
Eye damage/eye irritation
May cause slight eye irritation. May cause pain disproportionate to the level of irritation to eye tissues.
Skin corrosion/irritation
Prolonged exposure not likely to cause significant skin irritation.
Sensitization
Skin
No relevant data found.
Respiratory
No relevant data found.
Repeated Dose Toxicity
For the minor component(s): Isopropyl alcohol. In animals, effects have been reported on the
following organs: Liver.
Chronic Toxicity and Carcinogenicity
Similar cellulosics did not cause cancer in long-term animal studies.
Developmental Toxicity
Isopropanol has been toxic to the fetus in laboratory animals at doses toxic to the mother.
Reproductive Toxicity
In animal studies, a similar cellulosic has been shown not to interfere with reproduction.
Genetic Toxicology
Similar cellulosics were negative in both in vitro and animal genetic toxicity studies.
Component Toxicology - Hydroxyethyl cellulose
Skin Absorption The dermal LD50 has not been determined. ,

Skin Absorption For similar material(s): LD50, rabbit > 2,000 mg/kg
Component Toxicology - Sodium acetate
Skin Absorption LD50, rabbit > 10,000 mg/kg
Component Toxicology - Isopropanol
Skin Absorption LD50, rabbit > 12,800 mg/kg
Component Toxicology - Sodium acetate
Inhalation LC50, 1 h, Aerosol, rat > 30 mg/l
Component Toxicology - Isopropanol
Inhalation LC50, 6 h, Vapor, rat, male and female > 10,000 ppm

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Product Name: CELLOSIZE (TM) HYDROXYETHYL CELLULOSE Revision Date: 2012/08/27
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Section 12. Ecological Information

12.1 Toxicity
For the major component(s): Not expected to be acutely toxic to aquatic organisms. For the minor
component(s): Material is not classified as dangerous to aquatic organisms
(LC50/EC50/IC50/LL50/EL50 greater than 100 mg/L in most sensitive species).

12.2 Persistence and Degradability

For the major component(s): No appreciable biodegradation is expected. For the minor component(s)
Material is readily biodegradable. Passes OECD test(s) for ready biodegradability.
12.3 Bioaccumulative potential
Bioaccumulation: Based on information for component(s): Bioconcentration potential is low (BCF <
100 or Log Pow < 3).

12.4 Mobility in soil

Mobility in soil: For the major component(s):, Expected to be relatively immobile in soil (Koc > 5000).,
For the minor component(s):, Potential for mobility in soil is very high (Koc between 0 and 50).

12.5 Results of PBT and vPvB assessment

This substance has not been assessed for persistence, bioaccumulation and toxicity (PBT).
12.6 Other adverse effects
This substance is not in Annex I of Regulation (EC) 2037/2000 on substances that deplete the ozone
layer.

Section 13. Disposal Considerations

13.1 Waste treatment methods

Any disposal practice must be in compliance with all local and national laws and regulations. Do not
dump into any sewers, on the ground, or into any body of water.

Section 14. Transport Information

ROAD & RAIL
NOT REGULATED

OCEAN
NOT REGULATED

AIR
NOT REGULATED
Do not ship by air. See Section 7.

INLAND WATERWAYS
NOT REGULATED

Section 15. Regulatory Information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture

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European Inventory of Existing Commercial Chemical Substances (EINECS)

th
This product is a polymer according to the definition in Directive 92/32/EEC (7 Amendment to
Directive 67/548/EEC) and all of its starting materials and intentional additives are listed in the
European Inventory of Existing Commercial Chemical Substances (EINECS) or in compliance with
European (EU) chemical inventory requirements.

15.2 Chemical Safety Assessment

Not applicable.

Section 16. Other Information

Hazard statement in the composition section
H225 Highly flammable liquid and vapour.
H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness.

Risk-phrases in the Composition section

R11 Highly flammable.
R36 Irritating to eyes.
R67 Vapours may cause drowsiness and dizziness.

Revision
Identification Number: 78130 / 3005 / Issue Date 2012/08/27 / Version: 4.0
Most recent revision(s) are noted by the bold, double bars in left-hand margin throughout this
document.
Dow Chemical Company Ltd urges each customer or recipient of this (M)SDS to study it carefully and
consult appropriate expertise, as necessary or appropriate, to become aware of and understand the
data contained in this (M)SDS and any hazards associated with the product. The information herein is
provided in good faith and believed to be accurate as of the effective date shown above. However, no
warranty, express or implied, is given. Regulatory requirements are subject to change and may differ
between various locations. It is the buyer’s/user’s responsibility to ensure that his activities comply with
all federal, state, provincial or local laws. The information presented here pertains only to the product
as shipped. Since conditions for use of the product are not under the control of the manufacturer, it is
the buyer’s/user’s duty to determine the conditions necessary for the safe use of this product. Due to
the proliferation of sources for information such as manufacturer-specific (M)SDSs, we are not and
cannot be responsible for (M)SDSs obtained from any source other than ourselves. If you have
obtained an (M)SDS from another source or if you are not sure that the (M)SDS you have is current,
please contact us for the most current version.

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