Fetal Growth and Development

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FETAL GROWTH AND DEVELOPMENT

Sunday, 28 August 2022 8:41 PM

*Pre-embryonic - first 2 wks beginning with fertilization


*Embryonic - wks 3-8 considered the most critical fetal stage bcos of organogenesis
*Fetal - wks 8 to birth

NORMAL FETAL DEVELOPMENT


------------FIRST TRIMESTER-----------------
4 WEEKS
• Form of embryonic disc, not clearly defined features, spinal cord is formed; rudimentary heart
appears as a prominent bulge on the anterior surface, arms & legs bud like structures,
rudimentary eyes, ears, & nose are discernable
8 WEEKS
• Organogenesis is complete , heart beats rhythmically, facial features discernable, extremities
developed, external genitalia present but not distinguishable, primitive tail is regressing, abdomen
appears large as fetal intestines grows rapidly, sonogram shows gestational sac (diagnostic of
pregnancy)
12 WEEKS
• Nail beds forming, bone ossification begins, tooth buds present, sex distinguishable by outward
appearance, kidneys secrete, heartbeat audible by a doppler
----------SECOND TRIMESTER---------------
16 WEEKS
• Fetal heart sounds audible via fetoscope, lanugo is well formed, liver & pancreas functioning, fetus
amniotic fluid > intact but uncoordinated swallowing reflex, sex can be determined by ultrasound;
quickening felt by a multigravida
20 WEEKS
• Quickening felt by a primigravida, antibody production is possible, hair forms including eyebrows
& on head, meconium present in upper intestine, brown fat (aids in temp regulation @birth)
begins to be formed behind the kidneys, sternum, & posterior neck
• Fetal heart audible via stethoscope, vernix caseosa begins to form
24 WEEKS
• Passive antibody transfer from mother to fetus probably begins as early as 20 wks but certainly at
24 wks; born before this has taken place have no natural immunity & need more than the usual
protection against infectious disease in the newborn until infant's own store of IG's can build up
• Meconium present in the rectum, active production of lung surfactant begins, eyebrows &
eyelashes well defined, eyelids now open, pupils reactive to light, hears in response to sudden
sound
-----------THIRD TRIMESTER----------------
28 WEEKS
• Lung alveoli begins to mature, surfactant present in amniotic fluid, BV of the retina extremely
susceptible to damage from high O2 concentrations, the eyes open
32 WEEKS
• Subcutaneous fat begins to be deposited (former "stringy" old appearance is lost), fetus aware of
sounds outside the mother's body, active moro reflex present, birth position (vertex or breech)
may be assumed, iron stores provide iron for the time that the neonate will ingest only milk after
birth are beginning to be developed, fingernails grow to reach end of fingertips
36 WEEKS
• Additional amounts of SQ fats are deposited; sole of foot has only one or two crisscross creases,
lanugo begins to diminish, most babies turn into a vertex or head-down presentation during this
month
40 WEEKS

NCM 107 LEC Page 1


40 WEEKS
• Fetus kicks actively causing discomfort to the mother, vernix caseosa is fully formed, fingertips
extend over the fingertips
• In primiparas, the fetus often sinks into the birth canal during the last two wks (up to 4 wks),
giving the mother a feeling that her load is being lightened > lightening, fetal announcement that
the third trimester of pregnancy has ended and birth is at hand

NCM 107 LEC Page 2

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