Zn-Based Nanomaterials For Antimicrobial Applications A Short Review
Zn-Based Nanomaterials For Antimicrobial Applications A Short Review
Zn-Based Nanomaterials For Antimicrobial Applications A Short Review
https://doi.org/10.22214/ijraset.2023.49817
International Journal for Research in Applied Science & Engineering Technology (IJRASET)
ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538
Volume 11 Issue III Mar 2023- Available at www.ijraset.com
Abstract: In recent past, the investigations on antimicrobial activity of metal-based nanoparticles gained significant interest by
implantation of nanotechnology to synthesize the nanoparticles in nanoregion due to their high surface area and high reactivity.
Especially, the antimicrobial agents play a pivotal role in various fields where the biological contamination occurs. For
instance, microbes control the control the contamination of food in food packaging, in textile industry they can restrict the
growth of microorganisms owing to sweat, in medicine they can reduce the risk of contamination in invasive and routine
interventions. Owing to their enhanced specific surface area as reduced particle size lead to improved surface activity, zinc based
nano particles exhibit good antimicrobial properties. Further, zinc oxide is ecofriendly material which impacts photocatalysis
and photo oxidizing on biological and chemical species. This review focused on recent advancements in zinc based nano
materials for antimicrobial applications. Specifically, this briefly discussed the various synthesis techniques, shape of various
materials, different dopants that enhance the antimicrobial activity of zinc oxide along with antimicrobial properties of those
materials.
Keywords: Nanotechnology; Antimicrobial activity; Microorganisms; Surface area; Zinc nanoparticles;
I. INTRODUCTION
In recent decades Nanomaterials have been considered as one of the most vanguard materials. Nanomaterials have broad
applications in field of biological sciences, pharmaceutics, agriculture, medicine and industries[1]. Aside from ferrite nanoparticles,
metal oxide nanoparticles have intrigued much attention due to their surface area to volume ratios and magnetic properties, which
are wholly distinct from their corresponding bulk material. According to magnetic and crystal properties ferrites can be garnet,
spinel, orthoferrite or hexaferrite[2-5]. Among them, ferrite nanoparticles synthesized with transition metal with spinel structure
have been given special attention due to their well-known magnetic, catalytic, high adsorption, optical and electronic properties[6].
These nanoparticles are magnetically soft and easy to magnetize and demagnetize due to high permeability and good saturation
magnetization.[7-9] The properties of ferrite nanocrystals could be mould by adjusting the number of substituted transition metal
ions, shape, size and spinel ferrite nanocrystals can be employed in biomedicine to detect cancer cells, magnetic recording ,
magnetic hyperthermia for diagnostic and treatment of tumor, dopamine investigation, drug delivery, cellular signaling, and sensing
magneto-optical devices, catalysis, microwave device [10-13], heat absorbers and generators, energy storage, magnetic resonance
imaging (MRI) [14-16], electromagnetic interference shielding and water and wastewater treatment, Different methods are there to
synthesise spinel ferrite nanoparticles such as hydrothermal, microemulsions, aerosol spray pyrolysis, auto combustion, sol–gel, ball
milling, sonochemical, reverse micelles pulsed laser ablation in liquid, biogenic method using bacteria strains, polymeric precursor
and coprecipitation methods [17-21].Even though, different metal and metal oxides nanocrystals exhibits the antimicrobial nature
mainly Zinc oxide [22], Aluminum oxide [23],titanium oxide, nickel oxide and copper oxide were researchers reported in the
literature based on their intrinsic properties, surface modification, composition and the type of targeted bacteria. However, very little
is known about the antimicrobial applications of spinel ferrite nanoparticles substituted with transition metals. Antimicrobial activity
of manganese, nickel and copper substituted zinc ferrite NP’s to inhibit the bacterial infections, Samavati and Ismail et al.
[24]reported that the metal ions substituted spinel ferrite nanocrystals with increase their antimicrobial properties.A different class
of metallic nanoparticles are super paramagnetic iron-oxide nanoparticles (SPIONs) (e.g., maghemite (γ-Fe2O3) NPs and magnetite
(Fe3O4)) whose antibacterial efficiency enhance upon the utilisation of an external magnetic field. In order to enhance the
antibacterial tendency of metal-based NP’s is the use of carbon compounds and silica as delivery systems. In this review huge range
of metal substituted nanoparticles, synthesis, and their antibacterial activity were further explored.
©IJRASET: All Rights are Reserved | SJ Impact Factor 7.538 | ISRA Journal Impact Factor 7.894 | 1816
International Journal for Research in Applied Science & Engineering Technology (IJRASET)
ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538
Volume 11 Issue III Mar 2023- Available at www.ijraset.com
©IJRASET: All Rights are Reserved | SJ Impact Factor 7.538 | ISRA Journal Impact Factor 7.894 | 1817
International Journal for Research in Applied Science & Engineering Technology (IJRASET)
ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538
Volume 11 Issue III Mar 2023- Available at www.ijraset.com
Table 2: Recently introduced zinc based nanoparticles and their antimicrobial studies
Nano particle Morphology size Methods used Microorganism tested References
Zinc oxide –
rugged rod-like 500nm dynamic contact Streptococcus mutans 38
Copper oxide
Zinc oxide coated needle-shaped
Staphylococcus aureus , Escherichia
by CuNPs and 5 nm agar disk diffusion 39
coli
spherical
50– 400 Bacillus subtilis, Enterobacter
ZnO star-like surface contact 40
nm aerogenes
Escherichia coli and Staphylococcus
ZnO - 20–40 nm agar disk diffusion 41
aureus
agar well
ZnO nanoflowers - Escherichia coli 42
diffusion
Bacillus subtilis, Staphylococcus
120–400
ZnO - dynamic contact aureus , Escherichia coli 43
nm
Pseudomonas aeruginosa
ZnO hexagonal 70 nm surface contact Lactobacillus plantarum 44
Staphylococcus aureus ,
flake-like
Ag-ZnO 40nm agar disk diffusion Streptococcus, Escherichia coli, 45
aggregates
Pseudomonas,
NiO–ZnO/TiO2 dynamic contact
140– Candida albicans and Escherichia
nanotubes/Ti nanotubes with 46
210nm coli
irradiation
Sol-gel method by Escherichia coli, Staphylococcus
ZnO Spherical 18nm post heat aureus, Pseudomonas aeruginosa 47
treatment and Mycobacterium tuberculosis
Staphylococcus aureus,
Pseudomonas aeruginosa,
Chemical
ZnO Spherical 10nm Escherichia coli, Candida albicans, 48
synthesis
Aspergillus niger and Trichophyton
rubrum
Bacillus cereus, Pseudomonas
Sonochemical
ZnO rod 90-100nm aeruginosa, Staphylococcus aureus 49
method
and salmonella typhimurium
4.45±0.37 Chemical Staphylococcus aureus and
ZnO Spherical 50
nm precipitation Escherichia coli
Solvothermal Escherichia coli and Staphylococcus
ZnO Spherical 4,10,30 nm 51
method aureus
Wet chemical Staphylococcus aureus and
ZnO Spherical, rod 40-1200nm 52
synthesis Escherichia coli
©IJRASET: All Rights are Reserved | SJ Impact Factor 7.538 | ISRA Journal Impact Factor 7.894 | 1818
International Journal for Research in Applied Science & Engineering Technology (IJRASET)
ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538
Volume 11 Issue III Mar 2023- Available at www.ijraset.com
II. CONCLUSION
This review article addressed the recent advancements in zinc-based nanoparticles and their potential use for antimicrobial
applications. Further, the main issues regarding antimicrobial nanoparticles, including their synthesis techniques, types,
characterization of their properties, and their antimicrobial mechanisms, are discussed. Even though massive research is going on in
the advancement of biological synthesis techniques for introducing new materials with improved antimicrobial performance,
significant challenges are still remained. In recent years, researchers have put continuous research efforts to overcome the
challenges and also toward the development of new variety of materials.
REFERENCES
[1] M.G. Naseri, E.B. Saion, H.A. Ahangar, A.H. Shaari, M. J. Nanomater. 2010, 1–8, 2010
[2] Singh, R., & Thirupathi, G. Magnetic Spinels - Synthesis, Properties and Applications. Magnetic Spinels pp. 140–159, 2017
[3] K.K. Kefeni, B.B. Mamba, T.A. Msagati, Sep. Purif. Technol. 188, 399–422, 2017
[4] N. Sanpo, C. Wen, C.C. Berndt, J. Wang, ed. by A. Méndez-Vilas (Formatex Research Centre, Badajoz, 2013
[5] T. Mathew, S. Malwadkar, P. Shivanand, N. Sharanappa, C.P. Sebastian, Catal. Lett. 91, 217–224, 2003
[6] Y. Peng, Z. Wang, W. Liu, H. Zhang, W. Zuo, H. Tang, F. Chen, B.Wang,. Dalton Trans. 44(28),12871–12877, 2015
[7] H. Choi, S. Lee, T. Kouh, S.J. Kim, C.S. Kim, E. Hahn, J. Korean Phys. Soc. 70(1), 89–92,2017
[8] S. Reddy, B.K. Swamy, U. Chandra, K.R. Mahathesha, T.V. Sathisha, H. Jayadevappa, Anal. Methods 3(12), 2792–2796, 2011
[9] E. Céspedes, J.M. Byrne, N. Farrow, S. Moise, V.S. Coker, M. Bencsik, J.R. Lloyd, N.D. Telling, Nanoscale6(21), 12958–12970, 2014
[10] S. Joshi, V.B. Kamble, M. Kumar, A.M. Umarji, G. Srivastava, J. Alloys Compd. 654, 460–466, 2016
[11] C. Shu, H. Qiao, Symposium on Photonics and Optoelectronics, (SOPO 2009), Wuhan, pp. 1–4. IEEE, 2009
[12] L. Zhang, Y. Wu, J. Nanomater. 6, 1–6, 2013
[13] F. Waag, B. Gökce, C. Kalapu, G. Bendt, S. Salamon, J. Landers, U. Hagemann, M. Heidelmann, S. Schulz, H. Wende, N. Hart- mann, Sci. Rep. 7(1), 13161,
2017
[14] K.K. Kefeni, T.A. Msagati, B.B. Mamba, Mater. Sci. Eng. B 215, 37–55, 2017
[15] N.B. Velhal, N.D. Patil, A.R. Shelke, N.G. Deshpande, V.R. Puri,. AIP Adv. 5(9), 097166, 2015
[16] Q. Zafar, M.I. Azmer, A.G. Al-Sehemi, M.S. Al-Assiri, A. Kalam, K. Sulaiman, J. Nanopart. Res. 18(7), 186, 2016
[17] S. Dabagh, K. Chaudhary, Z. Haider, J. Ali, Results Phys. 8, 93–98, 2018
[18] M.H. Khedr, A.A. Omar, S.A. Abdel-Moaty, Colloids Surf. A 281(1–3), 8–14, 2006
[19] C.R. Vestal, Z.J. Zhang-. Chem. Mater. 14(9), 3817–3822, 2002
[20] K.V. Shafi, A. Gedanken, R. Prozorov, J. Balogh, Chem. Mater. 10(11), 3445–3450, 1998
[21] M. Gharagozlou, J. Alloys Compd. 486, 660–665, 2009
[22] M. Jalal, M.A. Ansari, S.G. Ali, H.M. Khan, S. Rehman, Artif. Cells Nanomed. Biotechnol. 14, 1–4, 2018
[23] M.A. Ansari, H.M. Khan, M.A. Alzohairy, M. Jalal, S.G. Ali, R.Pal, J. Musarrat, World J. Microbiol. Biotechnol. 31(1), 153–164, 2015
[24] A. Samavati, A.F. Ismail, Particuology 30, 158–163, 2017
[25] Supraja N, Prasad TNVKV, Krishna TG, David E, Appl Nanosci. 6(4):581–90. 2016.
[26] Luévano-Hipólito E, Torres-Martínez LM.. Materials Science and Engineering: B. Dec 1;226:223- 33, 2017.
[27] Fu L, Fu Z.. Ceram Int. 41(2):2492–6, 2015
[28] Wang ZL. J Phys Condens Matter. 16(25):R829.,2004.
[29] Kumar SG, Rao KKRsc Advances.;5(5):3306-51, 2015
[30] Thurlow LR, Thomas VC, Hancock LE.. J Bacteriol. 2009;191(20):6203–10.
[31] Foster TJ. FEMS microbiology reviews.;41(3):430-49. May 1, 2017
[32] Diallo A, Ngom BD, Park E, Maaza M. Journal of Alloys and Compounds.;646:425-30, Oct 15, 2015
[33] Diallo A, Ngom BD, Park E, Maaza M. 646:425-30, Oct 15; 2015
[34] Yang S, Wang J, Li X, Zhai H, Han D, Wei B, Wang D, Yang J. Applied surface science. 15;319:211-5, Nov 2014
[35] Ma QL, Xiong R, Zhai BG, Huang YM. Applied Surface Science. Jan 1;324:842-8, 2015
[36] Mintcheva N, Aljulaih AA, Wunderlich W, Kulinich SA, Iwamori S. Materials. Jul;11(7):1127, 2018
[37] Prasad TN, Sudhakar P, Sreenivasulu Y, Latha P, Munaswamy V, Reddy KR, Sreeprasad TS, Sajanlal PR, Pradeep T. Journal of plant nutrition. 1;35(6):905-27,
Apr 2012
[38] Matsuda, Y.; Okuyama, K.; Yamamoto, H.; Fujita, M.; Abe, S.; Sato, T.; Yamada, N.; Koka, M.; Sano, H.; Hayashi, M.; Sidhu, S. K.; Saito, T. Nucl. Instrum.
Methods Phys. Res., Sect. B, 458, 2019
[39] Medina-Ramírez, I. E.; Arzate-Cardenas, M. A.; Mojarro-Olmos, A.; Romo-López, M. A. Ceram. Int. 45, 17476–17488, 2019
[40] Esmailzadeh, H.; Sangpour, P.; Shahraz, F.; Hejazi, J.; Khaksar, R. Mater. Sci. Eng., C 58, 1058–1063, 2016
[41] Tantiwatcharothai, S.; Prachayawarakorn, J. Carbohydr. Polym.,227, 115360, 2020
[42] Ullah, S.; Ahmad, A.; Ri, H.; Il, K.; han, A. U.; Khan, U. A.; Yuan, Q. Appl. Organomet. Chem.,34, e5298, 2020
[43] Baysal, A.; Saygin, H.; Ustabasi, G. S.Environ. Health Eng. Manage. J. 6, 73–80, 2019
[44] Emamifar, A.; Kadivar, M.; Shahedi, M.; Soleimanian-Zad, S.Food Control 22, 408–413, 2011
[45] Dumbrava, A.; Berger, D.; Matei, C.; Prodan, G.; Aonofriesei, F.; Radu, M. D.; Moscalu, F. J. Inorg. Organomet. Polym. Mater., 29, 2072–2082, 2019
[46] Mohaghegh, N.; Faraji, M.; Abedini, A. J. Iran. Chem. Soc., 16,1207–1215, 2019
[47] Azam A, Ahmed AS, Oves M, Khan MS, Habib SS, Memic A, a comparative study. Int J Nanomed, 2012
[48] Dobrucka R, Dlugaszewska J, Kaczmarek M, Biomed Microdevices, 20(1):5, 2018.
©IJRASET: All Rights are Reserved | SJ Impact Factor 7.538 | ISRA Journal Impact Factor 7.894 | 1819
International Journal for Research in Applied Science & Engineering Technology (IJRASET)
ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538
Volume 11 Issue III Mar 2023- Available at www.ijraset.com
[49] Souza R, Haberbeck L, Riella H, Ribeiro D, Carciofi B Braz J Chem Eng., 36(2):885–93, 2019
[50] Saliani M, Jalal R, Kafshdare Goharshadi, Jundishapur J Microbiol 8(2):e17115,2015
[51] Bai X, Li L, Liu H, Tan L, Liu T, Meng X, ACS Appl Mater Interfaces, 7(2):1308–17, 2015
[52] Zare M, Namratha K, Byrappa K, Surendra D, Yallappa S, Hungund B, J Mater Sci Technol, 34(6):1035–43, 2018
©IJRASET: All Rights are Reserved | SJ Impact Factor 7.538 | ISRA Journal Impact Factor 7.894 | 1820