Journal of Organometallic Chemistry 696 (2011) 2406e2413

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Journal of Organometallic Chemistry

journal homepage: www.elsevier.com/locate/jorganchem

Synthesis and characterization of chalcogen (S and Se) derivatives

of 4-chloro- and 4-methoxy-N,N-diisopropylpyridine-2-carboxamide:
X-ray structure of 4-methoxy-3-(sulfanylmethyl)- and
4-chloro-3-(selenenylbenzyl)-N,N-diisopropylpyridine-2-carboxamide
Jaspreet S. Dhau*, Rupy Dhir, Amritpal Singh
Department of Chemistry, Punjabi University, Patiala 147002, India

a r t i c l e i n f o a b s t r a c t

Article history: Synthesis of chalcogen (S and Se) derivatives of 4-chloro- and 4-methoxy-N,N-diisopropylpyridine-2-
Received 22 January 2011 carboxamide (1a and 1b respectively) has been reported. 1a and 1b were lithiated with 2 equiv. of n-BuLi
Received in revised form or LDA at
78  C. Addition of elemental sulfur or selenium to the carbanion led to the formation of
24 February 2011
corresponding thiolate or selenolate anions respectively. The selenolate anions were aerial oxidized to
Accepted 3 March 2011
afford the corresponding diselenides. The thiolate/selenolate anions were quenched with a variety of
electrophiles to give unsymmetrical thio/selenoalkanes in moderate to good yields. Reductive cleavage of
Keywords:
SeeSe bond has also been studied. The synthesized compounds were characterized by elemental anal-
Organochalcogen
Pyridyl carboxamide
ysis, NMR (1H, 13C and 77Se), FT-IR and mass spectral techniques. Crystal structures of two compounds, 6b
Chalcogenides and 7a, were determined by single crystal X-ray crystallography. Their crystal structure exhibits 1,4-type
S/OCH3 and Se/Cl intramolecular secondary interactions respectively. The relative thermal stability of
3a, 3b and 4a has also been established by thermogravimetric analysis.
Ó 2011 Elsevier B.V. All rights reserved.

1. Introduction The chemistry of internally chelated organochalcogens with the

chalcogen atom attached to the benzene ring has been extensively
Interest in the field of organochalcogens having EeX (E ¼ S or studied, however, the corresponding pyridine chemistry is relatively
Se; X ¼ halogen, O or N) intramolecular secondary interactions under explored. This is probably due to the lack of efficient meth-
stems from their utility in organic synthesis [1,2], biochemistry odology for their synthesis. In this paper, we report an efficient and
[3e5] and material science [6,7]. These secondary interactions are convenient synthesis of various hitherto unknown internally
known to increase the stability of many organochalcogen chelated organosulfur and -selenium compounds derived from 4-
compounds [8,9]. Compared to organoseleniums, their sulfur chloro- and 4-methoxy-N,N-diisopropylpyridine-2-carboxamide (1a
congeners are more stable. However, compounds having SeeX and 1b respectively). Reductive cleavage of SeeSe bond with lithium
secondary interactions are found to be equally or in some cases aluminum hydride and sodium borohydride has also been studied.
even more stable than the organosulfur compounds devoid of these Single crystal X-ray studies of 4-methoxy-3-(sulfanylmethyl)- and 4-
interactions [10]. Internally stabilized organoseleniums have chloro-3-(selenenylbenzyl)-N,N-diisopropylpyridine-2-carboxamide
shown much better antioxidant properties, as they form stable (6a and 7b respectively) along with thermogravimetric analysis of
intermediates during the process involving the removal of oxidants 3a, 3b and 4a have also been described.
[11]. The metal chalcogenolates containing these moieties also
serve as excellent single source precursors of the semiconducting
materials [12,13]. In addition to these, the organoselenium 2. Results and discussion
compounds containing the pyridyl moieties serves as an efficient
reagents in the selenoxide elimination reactions for the synthesis of 2.1. Preparation of diselenide derivatives of 1a and 1b
terminal olefins [14].
Reaction of 1a or 1b with 2 equiv. of n-BuLi in dry THF at
78  C
affected lithiation at the b-position of the pyridine ring, resulting in
* Corresponding author. Tel.: þ91 175 3046409. the formation of reddish brown solution of the carbanion. Insertion
E-mail address: [email protected] (J.S. Dhau). of elemental selenium to the carbanion led to the formation of

0022-328X/$ e see front matter Ó 2011 Elsevier B.V. All rights reserved.
doi:10.1016/j.jorganchem.2011.03.009
 J.S. Dhau et al. / Journal of Organometallic Chemistry 696 (2011) 2406e2413 2407

corresponding selenolate anion. The selenolate anion, upon hydro- Table 1

lysis and subsequent aerial oxidation offered the corresponding Preparation of unsymmetrical thio- and selenoalkyl derivatives of 1a and 1b.

diselenide 3a and 3b respectively in good yields (Scheme 1). Both Entry Compound Y Reagent R X E Yield %
these compounds are high melting solids and are highly stable at 1 4a Cl n-BuLi eCH2eCH2eCH3 Br S 64
elevated temperatures (upto 260  C). 2 4b OCH3 n-BuLi eCH2eCH2eCH3 Br Se 60
3 5a Cl n-BuLi eCH3 I Se 61
4 5a Cl LDA eCH3 I Se 82
2.2. Preparation of unsymmetrical 3-sulfanyl- and 3-selenenylalkyl 5 5b OCH3 n-BuLi eCH3 I Se 64
derivatives of 1a and 1b 6 5b OCH3 LDA eCH3 I Se 78
7 6a Cl n-BuLi eC4H9 I Se 57
The thiolate/selenolate anions, formed by insertion of elemental 8 6b OCH3 LDA eCH3 I S 74
9 7a Cl n-BuLi eCH2C6H5 Cl Se 59
sulfur/selenium to the carbanion, were reacted with a variety of
10 8a Cl n-BuLi eCH2eCH2Br Br Se 40
electrophiles (Table 1) at
78  C, and then hydrolyzed at room
temperature to give 3-sulfanyl- and 3-selenenylalkyl derivatives of
1a and 1b in moderate to good yields (Scheme 1, Table 1). Further,
in an effort to synthesize bis(selenenyl) ethane, we reacted the 3a as a representative example. Addition of LiAlH4 powder to
selenolate anion of 1a with 1,2-dibromoethane. However to our a solution of 3a in dry THF immediately led to the change in the
surprise, 4-chloro-(3-selenenylethylbromide)-N,N-diisopropylpyr- color of the solution from dark orange to pale yellow with evolution
idine-2-carboxamide (8a) was the only product formed. This of hydrogen gas. Addition of iodomethane to this solution afforded
suggests toward the substitution of one of the two bromo group 5a in moderate yield. No product due to the action of LiAlH4 on the
with the selenolate (ReSe
) anion. carboxamide function was noticed in this reaction. Thus it can be
In another variation for the synthesis of unsymmetrical deriv- concluded that LiAlH4 chemoselectively cleaves SeeSe bond
atives, the carbanion was directly reacted with dibenzyl diselenide without disturbing the carboxamide group in these compounds.
to give the compound 8a in 41% yield. The performance of n-BuLi The use of NaBH4 in ethanol instead of LiAlH4 also led to an efficient
vis-a-vis LDA was also tested in the above reactions. It was found cleavage of SeeSe bond. The selenolate anion thus formed gave 5a
that the yields obtained with LDA were 15e20% more than that in near quantitative yield on quenching with iodomethane at 40  C
obtained with n-BuLi. Increasing the amount of LDA form 2 to (Scheme 2).
3 equiv. neither led to the formation of any dilithiated product nor
showed any substantial increase in the yield of the reaction. 2.4. Spectroscopic studies

2.3. Reductive cleavage of SeeSe bond in 3a The synthesized compounds were characterized by elemental
analysis, NMR (1H 13C and 77Se), FT-IR and mass spectral techniques.
Reducing agents like lithium aluminum hydride is known to Compared to the parent compound (1a and 1b), IR spectra of the
cleave SeeSe bond in various diorgano diselenides. However, it has compounds, 3ae8a and 3be6b, did not show any significant change
the potential to reduce the carboxamide functional group to the in the carbonyl stretching frequencies (yCO, 1624e1636 cm
1).
corresponding amines, aldehydes or alcohols. In light of these Interestingly, The peak corresponding to the yCO for 5b and 6b
findings, we decided to study the reductive cleavage SeeSe bond in appears almost at the same frequency. This indicates that the change

O
1a, Y = Cl; 1b, Y= OCH3 N

(i) n-BuLi/LDA (2.0 equiv.) N(i Pr)2

-78°C, THF

(ii) Se (ii) E (ii) Se

(ii) (PhCH2Se)2, -78°C
(iii) RX, -78°C (iii) BrCH2CH2Br
(iii) H2O, Air (iii) H2O
(iv) H2O (iv) H2O

Y Cl
Cl Y

Se SeCH2CH2Br
SeCH2Ph ER

O O
O O
N N
N N

N(i Pr)2 4a-7a 8a

7a N(i Pr)2 N(i Pr)2 N(i Pr)2
2 4b-6b (40%)
(41%)
3a (65%), Y = Cl; E = S, Se; R = methyl, propyl, butyl, benzyl
3b (61%), Y= OCH3

Scheme 1. Preparation of symmetrical diselenides and unsymmetrical 3-sulfanyl- and 3-selenenylalkyl derivatives of 1a and 1b.
2408 J.S. Dhau et al. / Journal of Organometallic Chemistry 696 (2011) 2406e2413

Cl Cl
(i) LiAlH4, Dry THF
Se or SeCH3

2 NaBH4, C2H5OH

O (ii) CH3I O
N N

(55% for LiAlH4)

N(i Pr)2 N(i Pr)2
(80% for NaBH4)

Scheme 2. Reductive cleavage of SeeSe bond with LiAlH4 or NaBH4.

in the chalcogen atom has no effect on the carbonyl stretching

frequencies of these compounds. The 1H NMR spectra of these
compounds shows two singlets in the aromatic region indicating
deprotonation of the parent compound. The spectra contains two
multiplets due to two non-equivalent eCH(CH3)2 groups and two
doublets corresponding to two non-equivalent isopropyl methyl
groups. Also, in the 13C NMR spectra there are two signals for the
methyne carbons and two signals for the methyl carbons. This
suggests restricted rotation about the CeN bond due to resonance
leading to the double bond character between carbon and nitrogen
in the molecule. There is no substantial change in the 13C chemical
shift of the carbonyl carbons in these compounds. In conclusion,
both the IR and the NMR data suggests toward the absence of E/O
(carbonyl) interactions. 77Se NMR of the compound 5a, 5b and 7a
were recorded with diphenyl diselenide as the external standard.
Change in the substituent around selenium atom results in large
change in the magnitude of chemical shift in its spectra. The sele- Fig. 2. TGA, DTA and Dr. TGA curves of 3b.
nium signal in the spectrum of 5a appears downfield at 162.04
(d ppm) when compared to 5b (93.79, d ppm), whereas, the signal in 2.5. Thermogravimetric studies
7a appears further downfield at 302.38 d (ppm). The ES mass spectra
of organoselenium compounds gave distinct molecular ion peaks Thermal stability of 3a is clearly depicted from the TG/DTA
with characteristic isotopic patterns. In addition to the molecular ion curves shown in Fig. 1. The compound 3a is thermally stable upto
peak, the mass spectrum of 3b exhibits a peak corresponding to 256  C and then decomposes in three stages. A large reaction
ReSee(Se)6eSeeR species at m/z 943. However, no product corre- interval of 341  C suggests that this compound decomposes very
sponding to this polyselenide species was isolated from the reaction slowly. DTG shows two peak maxima at 293  C and 382  C as the
mixture. The mass spectrum of all the unsymmetrical chalcogenides maximum rate of decomposition. The compound 3b is thermally
(4ae8a, 4be6b) not only showed a signal corresponding to the stable upto 266  C (Fig. 2). After this temperature it undergoes
molecular ion peak but also exhibited a peak at double the m/z value decomposition in two stages. No residue was left in the pan after
of the molecular ion peak. In this case also no such species was the full scan. This suggests that volatile selenium containing
found in any of the reaction products. Therefore, it appears that intermediates are formed during the decomposition process.
formation of the polyselenide species occurs only under the mass Reaction interval of 353  C is slightly higher that of 3a.
spectroscopic conditions. In order to compare the thermal stability of unsymmetrical
selenides, we investigated the thermal behavior of 4b. The

mg/

0.00

Fig. 1. TGA, DTA and Dr. TGA curves of 3a. Fig. 3. TGA, DTA and Dr. TGA curves of 4a.
 J.S. Dhau et al. / Journal of Organometallic Chemistry 696 (2011) 2406e2413 2409

Table 3
The shorter intramolecular distances (Å) in 6b and 7a () a.

Atoms in 6b Distance Atoms in 7a Distance

S(1)eO(1) 2.992 (3.32) Se (1)eCl(1) 3.345 (3.65)
O(1)eH(5B) 2.328 (2.72) O(1)eC(19) 3.045 (3.22)
O(2)eH(8C) 2.483 (2.72) O(1)eC(19) 3.028 (3.22)
O(2)eH(10B) 2.524 (2.72) O(1)eC(17) 2.814 (3.22)
e e O(1)eH(19C) 2.481 (2.72)
a
Values in the parenthesis is the sum of the van der Waals radii.

2,20 -dipryidyl disulfide (1.782 Å) [15] and the C(Sp3)eS bond length
Fig. 4. Molecular structure of 6b with atom numbering scheme. [1.787 (4) Å] is significantly shorter than that found in other
organosulfur compounds having C(Sp3)eS bond [16,17].
Selected bond length and angles of 7a are given in Table 2 and
compound 4b is thermally stable upto 212  C after which it its molecular structures with atom numbering scheme is shown in
decomposes in two steps (Fig. 3) leaving behind 9.52% residue, Fig. 5a. The molecule crystallizes in tetragonal P-42(1)c space
which is less than the expected percentage of selenium (22.3%) group with cell parameters (a ¼ 21.517(2) Å, b ¼ 21.517(2) Å,
present in the sample. DTG curve confirmed the two step decom- c ¼ 8.2988(13) Å, a ¼ 90 , b ¼ 90 , g ¼ 90 ,). The coordination
position, showing maximum rates of decomposition at 310  C and geometry around Se is V-shaped with bond angle C(8)eSe(1)eC(7)
359  C. Reaction interval of 165  C suggests that the decomposition of 98.01(18) . Intramolecular secondary 1,4-type Se(1)eCl(1)
is faster than 3a and 3b. From above discussion it is clear that the interaction was noticed in this compound (Fig. 5b, Table 3). The
thermal stability of these compounds is in the following order: 1,4-type chalcogeneheteroatom secondary interactions are very
3b > 3a > 4b rare and greatly influence the structural features of the
compounds [18,19]. Similar to 6b, no SeeO(carbonyl) secondary
2.6. Solid state structural features of 6b and 7a interaction was noticed. The dihedral angle between the planes
containing the amide group and pyridine ring are orthogonal to
Fig. 4 shows the molecular geometry and the crystallographic each other with CeO(carbonyl) bond pointing away from the
numbering scheme of 6b. Selected bond lengths and angles are selenium center. This is the reason behind the absence of any
listed in Table 2. The molecule crystallizes in orthorhombic Pbca 1,5-SeeO(carbonyl) intramolecular interactions. This observation
space group with cell parameters (a ¼ 14.730(5) Å, b ¼ 13.396(5) Å, is reflected in very small change in its carbonyl stretching
c ¼ 15.065(5) Å, a ¼ 90 , b ¼ 90 , g ¼ 90 ). frequency with respect to the parent compound (1a). It has been
An interesting aspect in the structure of 6b is the presence of found that the compounds showing 1,5-SeeO(carbonyl) interac-
intramolecular secondary 1,4-type S/OCH3 interaction. The S(1)e tions have selenium and oxygen atoms in the same plane [20]. The
O(1) atomic distance is 2.992 Å, which is significantly shorter than compounds which don’t have SeeO secondary interactions have
the sum of their van der Waals radii of 3.32 Å. Short intramolecular both these atoms in different planes [21]. The crystal packing
contacts are also observed between O(2)eH(8C) and O(2)eH(10B) diagram of 7a (Fig. 6) shows short intermolecular distances
(Table 3). No interaction is observed between sulfur and the between atoms listed in Table 4. Weak intermolecular C(3)eH(3)e
carbonyl oxygen as oxygen atom points away from the sulfur Se (CeHeSe angle of 126 ) and C(3)eH(3)eH(16A) interactions
center. Short intermolecular distances between O(2)eH(5A), O(2)e results in a V-shaped geometry around the H(3) with an angle H
C(5), H(5C)eH(13C) and C(5)eH(13C) (Table 4) are also observed in (16A)eH(3)eSe(1) of 72.69 . The rare CeHeSe intermolecular
the crystal structure. The SeMe unit is oriented out of the plane of secondary interactions have been reported in compounds with
the pyridine ring [torsion angle C(1)eC(14)eS(1)eC(5) of
53.2 ] CeHeSe angle of 129 [22]. The C(Sp3)eSe bond length is longer
mainly due to the steric effects of the ortho groups. The geometry and the C(Sp2)eSe bond length is comparable to that found in tris
around the sulfur is ‘V’ shaped with a C(14)eS(1)eC(5) angle of (2-pyridylseleno) methane [23]. The selenium atom is planar with
104.03 (19) and the geometry around C(9) and C(12) is distorted the pyridine ring whereas, it is orthogonal to the benzyl ring. The
tetrahedral due steric overcrowding. The C(Sp2)eS bond length bond angles and bond length of the pyridine ring is comparable to
[1.777 (4) Å] is slightly shorter than that found in 5,50 -dibromo- that in dipyridyl diselenide [24].

Table 2
Bond lengths [Å] and angles [ ] for 6b and 7a.

Compound 6b
N(2)eC(7) 1.348(5) N(2)eC(12) 1.468(6) O(2)eC(7) 1.229(5)
O(1)eC(1) 1.337(5) O(1)eC(6) 1.446(5) C(14)eS(1) 1.777(4)
C(9)eC(8) 1.512(6) C(4)eC(7) 1.519(6) S(1)eC(5) 1.787(5)
C(7)eN(2)eC(12) 122.3(4) C(12)eN(2)eC(9) 116.8(3) C(4)eC(14)eS(1) 118.9(3)
N(2)eC(9)eC(8) 112.5(3) C(8)eC(9)eC(10) 112.3(4) C(14)eC(4)eC(7) 120.1(4)
O(2)eC(7)eN(2) 124.7(4) C(11)eC(12)eC(13) 112.5(5) N(2)eC(12)eH(001) 102(3)
C(11)eC(12)eH(001) 110(4) C(9)eC(8)eH(8A) 109.5 C(14)eS(1)eC(5) 104.03(19)
Compound 7a
C(1)eC(7) 1.501(6) C(7)eSe(1) 1.974(4) C(8)eSe(1) 1.924(4)
C(9)eCl(1) 1.723(4) C(12)eC(13) 1.517(5) C(13)eO(1) 1.232(5)
C(13)eN(2) 1.338(5) C(14)eN(2) 1.465(5) C(14)eC(16) 1.527(7)
C(1)eC(7)eSe(1) 111.2(3) C(9)eC(8)eSe(1) 122.8(3) N(1)eC(12)eC(13) 114.7(3)
C(8)eC(12)eC(13) 120.0(4) O(1)eC(13)eN(2) 124.5(4) O(1)eC(13)eC(12) 116.7(4)
N(2)eC(14)eC(16) 112.7(4) C(16)eC(14)eC(15) 112.4(4) C(13)eN(2)eC(17) 120.7(4)
C(14)eN(2)eC(17) 116.8(4) C(8)eSe(1)eC(7) 98.01(18)
2410 J.S. Dhau et al. / Journal of Organometallic Chemistry 696 (2011) 2406e2413

Table 4
The shorter intermolecular distances (Å) in 6b and 7a ()a.

Atoms in 6b Distance Atoms in 7a Distance

O(2)eH(5A) 2.365 (2.72) Se (1)eH(3) 3.031 (3.1)
O(2)eC(5) 3.203 (3.22) H(16A)eH(3) 2.358 (2.4)
H(5C)eH(13C) 2.365 (2.4) H(14)eC(15) 2.830 (2.9)
C(5)eH(13C) 2.886 (2.9) O(1)eH(10) 2.561 (2.72)
e e N(1)eH(11) 2.730 (1.75)
e e H(7B)eC(2) 2.782 (2.9)
e e H(7B)eC(3) 2.825 (2.9)
a
Values in the parenthesis is the sum of the van der Waals radii.

3. Conclusion

Synthesis of organochalcogen (S, Se) compounds derived from

1a and 1b has been achieved by a method involving lithiation of 1a
and 1b with LDA/n-BuLi. The yield of the reaction involving the use
of LDA is better than that obtained in case of n-BuLi. The IR and 13C
NMR spectra of the prepared compounds indicates toward the
absence of EeO (carbonyl) interactions. The single crystal X-ray Fig. 6. Crystal packing of 7a.
structures of 6b and 7a substantiate the above facts, and establishes
the presence of 1,4-type S/OeCH3 and Se/Cl intramolecular
secondary interactions.
recorded in CDCl3 using TMS as internal standard on Bruker AC,
400 MHz spectrometer. 77Se NMR spectra were recorded in CDCl3
4. Experimental
using diphenyl diselenide as external standard on Bruker AMX500
spectrometer. The ESI mass spectra were taken on Water Q-TOF
4.1. General
Micro spectrometer. The elemental analysis was carried out by
using Elementar VarioMICRO analyzer. The thermogravimetric
All experiments were carried out in dry oxygen free nitrogen
analysis was done on Shimadzu DTG 60H (simultaneous TG/DTA
atmosphere. Infrared spectra were recorded between KBr pellets on
module). The samples were loaded on an Alumina crucible and
a PerkineElmer Model 1430. 1H NMR and 13C NMR spectra were
heated under nitrogen at the rate of 20  C/min. Compound 1a and
1b was prepared by literature method [25].

4.2. General method for the preparation of chalcogenolate anion of

1a and 1b

To a vigorously stirred solution of 1a (0.962 g, 4 mmol) or 1b

(0.90 g, 4 mmol) in dry THF at
78  C, n-BuLi (1.39 N in hexane,
6.0 ml, 8 mmol) was added drop-wise. The reaction mixture was
stirred for 2 h at the same temperature. To the dark red solution of
the carbanion, elemental selenium (0.632 g, 8 mmol) or sulfur
(0.257 g, 8 mmol) was added and the reaction mixture was slowly
brought to the room temperature. After the complete dissolution of
elemental chalcogen the reaction was subjected to conditions
described below.

4.2.1. Bis[3-(4-chloro-N,N-diisopropylpyridine-2-carboxamide)]
diselenide (3a)
The selenolate anion of 1a formed as above was hydrolyzed at
room temperature by adding 20 ml of water. The reaction mixture
was subjected to aerial oxidation for 30 min. The organic layer was
extracted with diethyl ether (3  50 ml) and dried over anhydrous
sodium sulfate. The solvent was removed on a rota-evaporator and
the crude residue was purified by column chromatography using
silica gel (60e120 mesh) and using hexaneeethyl acetate as eluent
(5:4). Yield 0.83 g (65%), m.p. 232e233  C, 1H NMR: CDCl3, 400 MHz
d (ppm): 8.34e8.35 (d, J ¼ 5.2 Hz, 2H), 7.34e7.35 (d, J ¼ 5.2 Hz, 2H),
3.55e3.61 (m, J ¼ 6.6 Hz, 2H), 3.43e3.49 (m, J ¼ 6.8 Hz, 2H),
1.48e1.49 (d, J ¼ 6.8 Hz, 12H,), 1.03e1.04 (d, J ¼ 6.6 Hz, 12H). 13C
NMR: CDCl3, 400 MHz d (ppm): 165.4, 160.2, 150.7, 148.4, 123.9,
123.6, 50.0, m 45.0, 19.6, 19.0. IR (KBr, cm
1): 2970, 1628, 1537, 1477,
1427, 1367, 1325, 1296, 1208, 1132, 1060, 850, 728, 616. MS (ESI): 639
Fig. 5. a: Molecular structure of 7a with atom numbering scheme. b: Molecular [Mþ$ 80Se]. Anal. Calcd (%) for C24H32Cl2N4O2Se2: C, 45.21, H, 5.02, N,
structure of 7a exhibiting intramolecular non-bonded interactions. 8.79. Found: C, 45.35, H, 5.30, N, 8.55.
 J.S. Dhau et al. / Journal of Organometallic Chemistry 696 (2011) 2406e2413 2411

4.2.2. Bis[3-(4-methoxy-N,N-diisopropylpyridine-2-carboxamide)] 495. MS (ESI): 335 [Mþ$, 80Se, 36Cl], Anal. Calcd (%) for
diselenide (3b) C13H19ClN2OSe: C, 46.80, H, 5.74, N, 8.39. Found: C, 46.83, H, 5.88,
The selenolate anion of 1b was hydrolyzed and subjected to N, 8.23.
aerial oxidation for 30 min. The reaction mixture was worked-up as
described above. Yield: 0.76 g (61%), 1H NMR: CDCl3, 400 MHz 4.3.4. 4-Methoxy-3-(selenenylmethyl)-N,N-diisopropylpyridine-2-
d (ppm): 8.35e8.37 (d, J ¼ 5.7 Hz, 2H), 6.75e6.77 (d, J ¼ 5.7 Hz, 2H), carboxamide (5b)
3.7 (s, 6H), 3.48e3.55 (m, J ¼ 6.6 Hz, 2H), 3.40e3.47 (m, J ¼ 6.8 Hz, Electrophile: Iodomethane (1.14 g, 0.5 ml, 8 mmol). Yield: 0.84 g
2H), 1.46e1.48 (d, J ¼ 6.8 Hz, 12H,), 1.01e1.03 (d, J ¼ 6.6 Hz, 12H). IR (64%, n-BuLi), 1.02 g (78%, LDA), m.p. 140e142  C, 1H NMR: CDCl3,
(KBr, cm
1): 2924, 1710, 1624, 1364, 1218, 1089, 927, 770, 668, 530. 400 MHz d (ppm): 8.47e8.48 (d, J ¼ 4.8 Hz, 1H), 6.91e6.92 (d,
MS (ESI): 631 [M þ H]þ 630 [Mþ$ 80Se], 629 [M
H]þ. Anal. Calcd J ¼ 4.8 Hz, 1H), 4.0 (s, 3H), 3.55e3.58 (m, 1H), 3.43e3.46 (m, 1H), 2.3
(%) for C26H38N4O4Se2: C, 49.69, H, 6.09, N, 8.91. Found: C, 49.76, H, (s, 3H), 1.60e1.62 (d, J ¼ 6.8 Hz, 6H), 1.22e1.24 (d, J ¼ 6.6 Hz, 6H). 13C
6.03, N, 8.49. NMR: CDCl3, 400 MHz d (ppm): 167.0, 166.7, 160.5, 150.6, 117.1, 106.1,
56.2, 50.8, 45.8, 20.6, 20.2, 18.1. 77Se NMR: d (ppm): 93.79. IR (KBr,
4.3. General method for the preparation of unsymmetrical cm
1): 3018, 2922, 2848, 1628, 1565, 1432, 1364, 1218, 1163, 1034,
3-sulfanyl- and 3-selenenylalkyl derivatives of 1a and 1b 770, 668, 530. MS (ESI): 329 [(M
H)þ, 80Se], 330, [Mþ$, 80Se], 331
[(M þ H)þ, 80Se]. Anal. Calcd (%) for C14H22N2O2Se: C, 51.07, H, 6.73,
The chalcogenolate anion of 1a/1b was cooled to
78  C and the N, 8.51. Found: C, 50.96, H, 6.89, N, 8.47.
desired electrophile (8 mmol) was added drop-wise. The reaction
mixture was slowly brought to room temperature and stirred for 4.3.5. 4-Chloro-3-(selenenylbutyl)-N,N-diisopropylpyridine-2-
30 min. The nitrogen supply to the reaction mixture was stopped. carboxamide (6a)
The reaction mixture was hydrolyzed and extracted with diethyl Electrophile: 1-Iodobutane (1.472 g, 0.91 ml, 8 mmol). Yield:
ether (3  50 ml). The organic layer was dried over anhydrous 0.85 g (57%), m.p. low melting point solid. 1H NMR: CDCl3, 400 MHz
sodium sulfate. The solvent was removed on a rota-evaporator and d (ppm): 8.31e8.32 (d, J ¼ 5.3 Hz, 1H), 7.28.7.27 (d, J ¼ 5.3 Hz, 1H),
the crude residue was purified by column chromatography using 3.44e3.50 (m, J ¼ 6.8 Hz, 1H), 3.32e3.38 (m, J ¼ 6.7 Hz, 1H), 2.9 (s,
silica gel and hexane-ethyl acetate as eluent (10:3). broad peak, 2H), 1.54e1.61 (m, J ¼ 7.2e7.6 Hz, 2H,), 1.51e1.53 (d,
J ¼ 6.8 Hz, 6H), 1.31e1.36 (m, 7.3e7.6 Hz, 2H), 1.10 (s, broad peak,
4.3.1. 4-Chloro-3-(sulfanylpropyl)-N,N-diisopropylpyridine-2- 6H), 0.80e0.84 (t, J ¼ 7.4 Hz, 3H). 13C NMR: CDCl3, 400 MHz
carboxamide (4a) d (ppm): 167.1, 162.8, 151.2, 149.6, 124.1, 122.6, 50.9, 45.9, 32.1, 30.1,
Electrophile: 1-Bromopropane (0.984 g, 0.73 ml, 8 mmol). Yield: 22.8, 20.5, 13.5. IR (KBr, cm
1): 2970, 1643, 1537, 1469, 1368, 1258,
0.8 g (64%), m.p. 68e70  C, 1H NMR: CDCl3, 400 MHz d (ppm): 1211, 1136, 1040, 830, 728, 634, 604, 531. MS (ESI): 377, [Mþ$, 80Se,
36
8.32e8.33 (d, J ¼ 5.2 Hz, 1H), 7.28e7.29 (d, J ¼ 5.2 Hz, 1H), Cl]. Anal. Calcd (%) for C16H25ClN2OSe: C, 51.15, H, 6.71, N, 7.45.
3.44e3.51 (m, J ¼ 6.8 Hz, 1H), 3.28e3.34 (m, J ¼ 6.6 Hz, 1H), Found: C, 51.47, H, 6.71, N, 7.29.
2.86e2.90 (m, 2H), 1.52e1.53 (d, J ¼ 6.7 Hz, 6H,), 1.32e1.37 (m, 2H),
1.05e1.12 (broad doublet, 6H), 0.81e0.85 (t, J ¼ 7.3 Hz, 3H). 13C 4.3.6. 4-Methoxy-3-(sulfanylmethyl)-N,N-diisopropylpyridine-2-
NMR: CDCl3, 400 MHz d (ppm): 166.3, 162.0, 151.2, 149.3, 127.6, carboxamide (6b)
124.4, 51.0, 45.9, 38.3, 36.1, 31.4, 22.9, 21.8, 20.5, 13.6. IR (KBr, cm
1): Electrophile: Iodomethane (1.14 g, 0.5 ml, 8 mmol). Yield: 0.83 g,
2929, 2435, 2132, 1716, 1636, 1439, 1364, 1218, 1090, 771, 670, 530. (74%), m.p. 142e143  C, 1H NMR: CDCl3, 400 MHz d (ppm):
MS (ESI): 314 [Mþ$]. Anal. Calcd (%) for C15H23ClN2OS: C, 57.22, H, 8.32e8.33 (d, J ¼ 5.8 Hz, 1H), 6.71e6.73 (d, 5.8 Hz, 1H), 3.90 (s, 3H),
7.36, N, 8.90, S, 10.18. Found: C, 57.52, H, 7.33, N, 8.11, S, 9.31. 3.44e3.48 (m, 1H), 3.37e3.40 (m, 1H), 2.29 (s, 3H), 1.51e1.53 (d,
J ¼ 6.8 Hz, 6H), 1.08e1.09 (d, 6H). 13C NMR: CDCl3, 400 MHz
4.3.2. 4-Methoxy-3-(selenenylpropyl)-N,N-diisopropylpyridine-2- d (ppm): 167.5, 166.5, 160.7, 150.6, 111.7, 105.9, 56.2, 50.9, 45.9, 29.7,
carboxamide (4b) 20.6, 20.2, 8.3. IR (KBr, cm
1): 2922, 2435, 1629, 1560, 1458, 1364,
Electrophile: 1-Bromopropane (0.984 g, 0.73 ml, 8 mmol). Yield: 1338, 1217, 1035, 756, 667, 530, 458. MS (ESI): 282 [M]þ$. Anal. Calcd
0.86 g (60%), m.p. 46e48  C, 1H NMR: CDCl3, 400 MHz d (ppm): (%) for C14H22N2O2S: C, 59.54, H, 7.85, N, 9.91, S, 11.35. Found: C,
8.39e8.40 (d, J ¼ 5.6 Hz, 1H), 6.73e6.75 (d, J ¼ 5.7 Hz, 1H), 3.95 (s, 59.71, H, 7.81, N, 9.64, S, 11.01.
3H), 3.44e3.56 (m, J ¼ 6.8, 6.2, 6.7 Hz, 2H), 2.86e2.91 (t, J ¼ 7.3,
7.4 Hz, 2H), 1.66.1.69 (m, 2H), 1.56e1.65 (d, J ¼ 8.0 Hz, 6H), 1.15e1.17 4.3.7. 4-Chloro-3-(selenenylbenzyl)-N,N-diisopropylpyridine-2-
(d, J ¼ 6.6 Hz, 6H), 0.95e0.98 (t, J ¼ 7.3, 7.4 Hz, 3H). 13C NMR: CDCl3, carboxamide (7a)
400 MHz d (ppm): 167.1, 167.0, 161.0, 150.3, 111.2, 105.8, 99.9, 56.2, Method A: Electrophile: Benzyl chloride (1.01 g, 0.92 ml,
50.9, 45.9, 32.2, 23.6, 20.6, 14.4, 1.02. IR (KBr, cm
1): 2966, 1625, 8 mmol). Yield: 1.0 g, (59%).
1566, 1468, 1427, 1371, 1335, 1296, 1212, 1132, 1039, 817, 751, 616. Method B: To a vigorously stirred solution of 1a (0.962 g,
MS (ESI): 359 [M þ H]þ. Anal. Calcd (%) for C16H26N2O2Se: C, 53.78, 4 mmol) in dry THF at
78  C, n-BuLi (1.39 N in hexane, 6.0 ml,
H, 7.33, N, 7.84. Found: C, 53.69, H, 7.22, N, 7.58. 8 mmol) was added drop-wise. The reaction mixture was stirred for
2 h at the same temperature. To the dark red solution of the carb-
4.3.3. 4-Chloro-3-(selenenylmethyl)-N,N-diisopropylpyridine-2- anion, dibenzyl diselenide (2.74 g, 8 mmol) was added and the
carboxamide (5a) reaction mixture was slowly brought to the room temperature and
Electrophile: Iodomethane (1.14 g, 0.5 ml, 8 mmol). Yield: 0.81 g worked-up as described above. Yield: 0.71 g, (41%) m.p. 104e106  C,
(61%, n-BuLi), 1.1 g (82%, LDA) m.p. 82e84  C, 1H NMR: CDCl3, 1
H NMR: CDCl3, 400 MHz d (ppm): 8.32e8.33 (d, J ¼ 5.2 Hz, 1H),
400 MHz d (ppm): 8.39e8.41 (d, J ¼ 5.3 Hz, 1H), 7.36e7.37 (d, 7.23e7.24 (d, J ¼ 5.2 Hz, 1H), 7.17e7.22 (m, 2H), 7.09e7.16 (m, 3H),
J ¼ 5.2 Hz, 1H), 3.52e3.59 (m, J ¼ 6.9 Hz, 1H), 3.3e3.42 (m, 4.19 (s, 2H), 3.45e3.52 (m, J ¼ 6.8 Hz, 1H), 3.33e3.39 (m, J ¼ 6.6 Hz,
J ¼ 6.7 Hz, 1H), 2.3 (s, 3H), 1.59e1.69 (d, J ¼ 6.9 Hz, 6H,), 1.18e1.20 1H), 1.53e1.55 (d, J ¼ 6.9 Hz, 6H), 1.08e1.09 (d, J ¼ 6.6 Hz, 6H). 13C
(d, 6.6 Hz, 6H), 0.9 (t, 3H). 13C NMR: CDCl3, 400 MHz d (ppm): NMR: CDCl3, 400 MHz d (ppm): 167.2, 163.1, 151.6, 149.9, 137.5,
166.9, 161.9, 151.1, 149.3, 124.3, 123.4, 51.0, 46.0, 20.5, 20.1, 9.6. 77Se 129.2, 128.4, 127.1, 124.0, 122.6. 77Se NMR: d (ppm): 302.38. IR (KBr,
NMR: d (ppm): 162.04. IR (KBr, cm
1): 2968, 2361, 1629, 1547, 1466, cm
1): 2968, 2363, 1631, 1542, 1475, 1424, 1368, 1324, 1212, 1039,
1422, 1370, 1331, 1209, 1162, 1098, 916, 824, 733, 634, 605, 532, 866, 763, 724, 594. MS (ESI): 441 [Mþ$, 80Se, 36Cl]. Anal. Calcd (%) for
2412 J.S. Dhau et al. / Journal of Organometallic Chemistry 696 (2011) 2406e2413

Table 5 brought to room temperature and stirred for 2 h. The pale yellow
Crystal data collection and structure refinement parameters of compound 6b and 7a. solution was again cooled to 0  C and iodomethane (0.05 ml,
Empirical formula C14 H22 N2 O2S C19 H23Cl N2OSe 0.88 mmol) was added drop-wise. The resulting solution was stir-
Formula weight 282.40 409.80 red overnight and hydrolyzed with 20 ml of water the next day. The
Temperature 293(2) K 293(2) K usual workup procedure afforded 5a in 55% (0.14 g) yield.
Wavelength 0.71069 Å 0.71073 Å
Crystal system Orthorhombic Tetragonal
Method B: To a vigorously stirred solution of 3a (0.1 g,
Space group Pbca P-42(1)c 0.16 mmol) in absolute ethanol at 0  C, NaBH4 (0.015 g, 0.39 mmol)
Unit cell was added in small installments. The reaction mixture was slowly
dimensions brought to room temperature and stirred for 3 h at 40  C. The pale
a 14.730(5) Å 21.517(2) Å
yellow solution was again cooled to 0  C and iodomethane
b 13.396(5) Å 21.517(2) Å
c 15.065(5) Å 8.2988(13) Å (0.025 ml, 0.44 mmol) was added drop-wise. The resulting solution
a 90.0(5) . 90.0 was stirred overnight 40  C and hydrolyzed with 20 ml of water the
b 90.0(5) . 90.0 next day. The usual workup procedure afforded 5a in 80% (0.085 g)
g 90.0(5) . 90.0 yield.
Volume 2972.7(18) Å3 3842.0(8) Å3
Z 8 8
Density 1.262 Mg/m3 1.417 Mg/m3
(calculated) 4.5. Crystal structure determination and refinement
Absorption 0.218 mm
1 2.101 mm
1
coefficient Single-crystal X-ray data of 6b and 7a were collected using
F(000) 1216 1680 graphite-monochromated Mo-Ka radiation (l ¼ 0.71073 Å) on
Crystal size 24  18  16 mm3 0.34  0.32  0.28 mm3
Theta range for 2.46e26.50 . 1.89e25.48 .
“Bruker SMART APEX CCD diffractometer” at 100 K. The linear
data collection absorption coefficients, scattering factors for the atoms and the
Index ranges 18h18, 26h25, anomalous dispersion corrections were taken from the Interna-
12k16, 22k26, tional Tables for X-ray Crystallography [26]. The program SMART was
18l18
6l10
used for collecting frames of data, indexing reflections, and deter-
Reflections collected 15925 20059
Independent 3072 [R(int) ¼ 0.0591] 3554 [R(int) ¼ 0.0905] mining lattice parameters. The data integration and reduction were
reflections processed with SAINT [27] software. An empirical absorption
Completeness theta ¼ 26.50 99.6% 99.8% correction was applied to the collected reflections with SADABS
to theta ¼ 25.48 [28] using XPREP [29]. All the structures were solved by the direct
Absorption None None
correction
method using the program SHELXS-97 [30] and were refined on F2
Max. and min. 0.5907 and 0.5352 by the full-matrix least-squares technique using the SHELXL-97
transmission program package. All non-hydrogen atoms were refined with
Refinement method Full-matrix least- Full-matrix least- anisotropic displacement parameters in all the structure. All other
squares on F2 squares on F2
relevant information about the data collection and refinement are
Data/restraints/ 3072/0/180 3554/0/217
parameters presented in Table 5.
Goodness-of-fit 1.109 1.044
on F2
Final R indices R1 ¼ 0.0940, R1 ¼ 0.0403, Acknowledgments
[I > 2s(I)] wR2 ¼ 0.2336 wR2 ¼ 0.0826
R indices (all data) R1 ¼ 0.1093, R1 ¼ 0.0543,
We are thankful to the CSIR, New Delhi, India, for financial
wR2 ¼ 0.2445 wR2 ¼ 0.0890
Absolute structure
0.018(11) support. Additional support from SAP by UGC, New Delhi, is also
parameter acknowledged. We are also thankful to Mr. Avtar Singh, CIL, Punjab
Largest diff. peak 2.593 and
0.357 e Å
3 0.514 and
0.527 e Å
3 University, Chandigarh, for NMR spectra. Thanks are also
and hole acknowledged to Prof. P. Bhardwaj and Dr. Kamlesh Thapliyal, and
Dr. Sarvendra Kumar IIT, Kanpur, for single crystal X-ray studies on
C19H23ClN2OSe: C, 55.69, H, 5.65, N, 6.83. Found: C, 55.78, H, 5.79, N, 6b and 7a.
6.66.
Appendix. Supplementary material
4.3.8. 4-Chloro-(3-selenenylethylbromide)-N,N-diisopropylpyridine-
2-carboxamide (8a)
CCDC Nos. 791167 (6b); 791168 (7a) contains the supplementary
Electrophile: 1,2-Dibromoethane (0.75 g, 0.35 ml, 4 mmol).
crystallographic data for this paper. Crystallographic data for the
Yield: 0.68 g, (40%) m.p.100e102  C, 1H NMR: CDCl3, 400 MHz
structure analysis have been deposited with the Cambridge Crys-
d (ppm): 8.44e8.45 (d, J ¼ 5.3 Hz, 1H), 7.39e7.40 (d, J ¼ 5.2 Hz, 1H),
tallographic Data Center. CCDC numbers are 791167 for 4-methoxy-
3.63 (s, broad peak, 2H), 3.51e3.58 (m, J ¼ 6.6 Hz, 1H), 3.37e3.44
3-(sulfanylmethyl)-N,N-diisopropylpyridine-2-carboxamide (6b)
(m, J ¼ 6.6 Hz, 1H), 3.40 (s, broad peak, 2H), 1.58e1.60 (d, J ¼ 6.6 Hz,
and 791168 for and 4-chloro-3-(selenenylbenzyl)-N,N-diisopro-
6H), 1.16e1.18 (d, J ¼ 6.6 Hz, 6H). IR (KBr, cm
1): 2971, 1632, 1537,
pylpyridine-2-carboxamide (7a). Copies of this information may be
1476, 1422, 1367, 1324, 1209, 1161, 1040, 827, 728, 634, 569. MS
obtained free of charge from the Director, 12 Union Road, Cam-
(ESI): 427 [Mþ$, 80Se, 35Cl]. Anal. Calcd (%) for C19H23ClN2OSe: C,
bridge CB2 1EZ, UK, fax: þ44 1223 336 033; or e-mail: deposite@
39.42, H, 4.72, N, 6.57. Found: C, 39.55, H, 4.65, N, 6.70.
ccdc.cam.ac.uk or http://www.ccdc.cam.ac.uk.

4.4. Reductive cleavage of SeeSe bond in 3a

Appendix. Supplementary material
Method A: To a vigorously stirred solution of 3a (0.25 g,
0.4 mmol) in dry THF at 0  C, powdered LiAlH4 (2.24 g, 0.88 mmol) Supplementary data related to this article can be found online at
was added in small installments. The reaction mixture was slowly doi:10.1016/j.jorganchem.2011.03.009.
 J.S. Dhau et al. / Journal of Organometallic Chemistry 696 (2011) 2406e2413 2413

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