Opthalmoloy PDF
Opthalmoloy PDF
Opthalmoloy PDF
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Ophthalmology
Anterior uveitis
➢ Also referred to as “iritis” or “iridocyclitis”. It is one of the important differentials of a red eye
Features
Acute anterior uveitis
• Progressive (over a few hours/days) unilateral, painful red eye
• Reduced visual acuity
• Photophobia
• Pupil → abnormal shape/size
- Small pupil, initially from iris spasm
- Later it may be irregular or dilate irregularly due to adhesions
between lens and iris
• Excess tear production
• Characteristic sign → cells in the aqueous humour seen on slit-lamp
- Aqueous humour is cloudy, giving the appearance of a 'flare'. This appears rather like a shaft of light
shining through a darkened, smoky room
- Anterior chamber flare is due to inflamed vessels leaking protein. Due to the cloudiness, as the slit-
lamp beam of light is shone through, the beam disperses hence the term flare
Associated conditions
• Ankylosing spondylitis • RA → Sclera
• AS → Uveitis
• Reactive arthritis
• IBD
Management
• Prednisolone eye drops → to reduce inflammation
• Cyclopentolate → to prevent adhesions between lens and iris by keep pupil dilated
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Ophthalmology
Central retinal vein occlusion (CRVO)
Causes
• Glaucoma • CRAO → No blood → Pale sclera
• Hypertension • CRVO → Blood obstructed → Hemorrhage
• Polycythemia
Presentation
• Similar to those with central retinal artery occlusion (CRAO) Hypertensive retinopathy
• Unilateral sudden loss of vision, may occur overnight - Asymptomatic, sudden, bilateral loss of vision
• NO pain, redness, or abnormality in pupillary dilation
Diagnosis
• Retinal hemorrhages → the main way of distinguishing venous obstruction from arterial obstruction
- You cannot have a hemorrhage in the retina if you don't have blood getting into the eye
• Fundoscopy
- Disk swelling, venous dilation, tortuosity, and retinal hemorrhages
(flame-shaped hemorrhages)
- Stormy sunset or tomato splash appearance
Treatment
• Immediate referral to an ophthalmologist and/or intra-vitreal steroids
Investigations
• Diagnosis is usually clinical and investigations are aimed at ruling out underlying diseases
• The most important cause to rule out is giant cell arteritis (10%) → visual loss is reversible
Management
• If the patient presents within 90-100 minutes of onset → firm ocular massage. The idea behind this is to try
to dislodge the obstruction
• This only works very occasionally and immediate referral is mandatory
Branch retinal artery occlusion (BRAO) → wedge-shaped pallor sparing the rest of the optic disc
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Ophthalmology
Optic neuritis
➢ Inflammation of the optic nerve
Presentation
• Classically there is a triad of clinical features which are
- Reduced vision (of varying severity) → Usually unilateral. Progresses for less than 2 weeks and
spontaneously improves within 3 weeks
- Eye pain → Particularly on movement
- Impaired color vision → Initially loss of red color vision
• One of the most common cause of optic neuritis is multiple sclerosis → Seen especially in Caucasian
populations the stem would usually (but not always) include a female patient as multiple sclerosis is more
prevalent in the female gender
Examination
• Swollen optic disc
• Optic disc becomes pale later (4 to 6 weeks after onset)
• Relative afferent pupillary defect (RAPD) (Marcus Gunn pupil)
• Central scotoma may occur
RAPD
- When light is directed towards the unaffected eye, both pupils constrict
- When light is directed towards the affected eye, both pupils do NOT constrict (appear relatively dilated)
RAPD = damage to the whole optic nerve = mononuclear field loss
If NO RAPD = ONLY a part of optic nerve is affected = Central scotoma
Central scotoma → A blind spot in the middle of one’s vision
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Ophthalmology
DM-related retinopathy
Background retinopathy (not proliferative) → [Painting as background]
• Microaneurysms (dots)
• Hemorrhage (blots)
• Hard exudates
Pre-proliferative retinopathy
• Addition of Cotton wool spots
Proliferative retinopathy
• Addition of new vessel formation (neovascularization)
• More serious. Progresses rapidly to blindness. Neovascularization may lead to vitreous hemorrhage
• Floaters in vision
• Laser photocoagulation is needed
Hypertensive retinopathy
➢ Most patients are asymptomatic
Chronic hypertension
• BP >140/90 mmHg
• Usually asymptomatic
• Fundoscopy
- Bilateral attenuation of arterial vessels (copper or silver wiring)
- Arteriovenous nipping/nicking (where arteries cross the veins)
- Eventually, hemorrhage and exudates
Malignant (accelerated) hypertension
• BP >180/110
• May have headache and decreased vision
• Fundoscopy
- Hard exudates, appear as (macular star), thin white streaks radiating around the macula
- Disc swelling
- Cotton wool spots
- Flame hemorrhage, also found in diabetic retinopathy and CRVO
- Arterial or venous occlusion
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Ophthalmology
Amaurosis fugax
➢ Painless transient monocular visual loss (i.e. loss of vision in one eye that is not permanent)
➢ It is indicative of retinal ischemia, usually associated with emboli or stenosis of the ipsilateral carotid artery
➢ Resolves spontaneously (15-30 minutes)
Presentation
• Sudden, unilateral vision loss; “black curtain coming down”
• Duration: 5-15 minutes; resolves within < 24 hours
• Associated with stroke or transient ischemic attack (TIA) and its risk factors (i.e. HTN, atherosclerosis)
• Has an association with giant cell arteritis
• Curtains = CRAO (Amaurosis Fugax) or Retinal detachment
Retinal detachment
➢ Usually spontaneous, but it may result from trauma
➢ It occurs when the force that holds the retinal attachment fails which results in accumulation of fluid in the
subretinal spaces
➢ The two most common predisposing factors are extreme myopia and surgical extraction of cataracts,
proliferative retinopathy from diabetes, CRVO, and age-related macular degeneration
Presentation
• The classic symptom is → photopsia (flashing lights)
• A common presentation is unilateral blurry vision without pain or redness
• The patient may complain of seeing “floaters” as well as flashes at the periphery of vision
• Sometimes it is described as a "curtain coming down," as the retina falls off the sclera behind it
Detachment presents with 5 ‘F’s
- Floaters (tiny black dots)
- Flashes
- Field loss
- Fall in acuity
- Falling curtain
Diagnosis
• Direct ophthalmoscopy → grey, opaque and wrinkled retina, ballooning forward
Treatment
• Patients should lean their heads back to promote the chance that the retina will fall back into place
• The retina can be mechanically reattached to the sclera surgically, by laser photocoagulation, cryotherapy,
or by the injection of expansile gas into the vitreal cavity (gas will press the retina back into place)
• Scleral buckling, a "buckle," or belt, can be placed around the sclera to push the sclera forward so that it can
come into contact with the retina
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Ophthalmology
Conjunctivitis
Acute dacryocystitis
➢ Acute inflammation of the lacrimal sac, often as a result of infection
Presentation
• Symptoms and signs are over the region of the lacrimal sac (but may spread to the nose and face with teeth
pain being experienced by some)
• Therefore, look just lateral and below the bridge of the nose for:
- Excess tears (epiphora)
- Pain
- Swelling and erythema at the inner canthus of the eye
Management
• Immediate antibiotic therapy may resolve the infection
- Children → Co-amoxiclav or Cefaclor
- Adults → Co-amoxiclav or Cefalexin
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Ophthalmology
Cataract
➢ Clouding of the lens, Glare at night, Dazzle at light
➢ May cause gradual loss of vision (frequent changes of glasses), absent red reflex
➢ Children may present with squint, loss of binocular function or a white pupil
Risk factors
• Exposure to great amount of UV light (e.g. person from Australia who never wears glasses)
• Long term use of corticosteroids (e.g. an asthmatic patient on Oral steroids)
• Smoking, DM
• High myopia
• Eye trauma
Management
• Lens extraction
Keratitis
- Inflammation of the cornea
- Herpes simplex keratitis → presents with a dendritic corneal ulcer
- Treated by topical acyclovir, steroid drops are contraindicated → flaring up and blindness
CMV Retinitis
• History of positive HIV, attends he clinic with visual deterioration
• Pizza retina
- Hemorrhages → tomato sauce
- Yellowish exudate → cheese
Presentation
• Decreased visual acuity, floaters, and loss of visual fields on one side
• Fundoscopy → yellow-white cloudy retinal lesions. Lesions may appear at the periphery of the fundus, but
they progress centrally
• On examination, multiple cotton wool spots can be seen
• Starts unilateral then bilateral
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Ophthalmology
Ocular manifestations os rheumatoid arthritis (RA)
• Keratoconjunctivitis sicca → most common
• Episcleritis → erythema + pain (less severe than scleritis) • Ankylosing spondylitis → Iris
• Scleritis → erythema + pain • RA → Sclera [RAS]
• Iatrogenic steroid-induced cataract
Keratoconjunctivitis sicca
• Dry, itchy, gritty eye due to decreased lacrimation + sandy feeling under the eyes
• Can be found in RA or Sjogren $
• Schirmer’s test → <10mm
• Treated by artificial tears (Hypromellose, sodium chloride, sodium hyaluronate)
• Topical ciclosporin can be used
Retinitis pigmentosa
• Positive family history
• Initially → night blindness
• Peripheral visual field loss
Subconjunctival hemorrhage
• Presents as a bloodshot eye
• Occurs due to a small bleed from one of the minor conjunctival vessels on the surface of the eye
• May be caused by HTN, straining (coughing or sneezing), trauma or spontaneously (with no apparent cause)
Management
• Trauma → CT
• HTN → BP monitoring
• Recurrent, patient is on anticoagulation → Check INR
• If no apparent cause → Reassure
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Ophthalmology
Notes
• Colored halos → Closed angle glaucoma
• Glare at night → Cataract
• Flare → Iritis
• Floaters → Anterior Uveitis, retinal detachment, proliferative DM retinopathy, CMV retinitis
• Peripheral visual field loss → Open angle glaucoma
• Central scotoma → Optic neuritis
• Bilateral paracentral scotoma → Pituitary tumor compressing optic chiasma, may progress to arcuate,
double arcuate scotomas and eventually tunnel vision
• Bitemporal hemianopia → Pituitary tumor compressing optic chiasma
• Homonymous hemianopia → Optic tract lesions
• A child with acute onset of swelling, redness, increase warmth and tenderness of the eyelid with fever →
Periorbital cellulitis
• If it involves orbital signs such as gaze restriction, proptosis and pain on eye movements → Orbital cellulitis,
an emergency that requires → IV antibiotics, if CT confirms abscess → Drainage
• Hypermetropia = Farsightedness
• Myopia = Nearsightedness
• Degenerative corneal disease [Kill The Blue Parrot]
- Keratoconus, a cone-shaped cornea
- Terrien marginal degeneration, bilateral peripheral thinning of the cornea
- Band keratopathy, characterized by deposition of calcium
- Pellucid marginal degeneration, bilateral peripheral thinning of the cornea
• Central retinal artery is a branch of the ophthalmic which arises from the internal carotid artery
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