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First Aid
Perioperative
Ultrasound
Acute Pain Manual for Surgical
Procedures
Jinlei Li · Wei Jiang
Nalini Vadivelu Editors
123
First Aid Perioperative Ultrasound
Jinlei Li • Wei Jiang
Nalini Vadivelu
Editors
First Aid
Perioperative
Ultrasound
Acute Pain Manual for Surgical
Procedures
Editors
Jinlei Li Wei Jiang
Department of Anesthesiology Shanghai Jiaotong University
Yale University Shanghai Sixth People’s Hospital
New Haven, CT, USA Shanghai, China
Nalini Vadivelu
Department of Anesthesiology
Yale University
New Haven, CT, USA
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2023
This work is subject to copyright. All rights are solely and exclusively licensed by
the Publisher, whether the whole or part of the material is concerned, specifically
the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting,
reproduction on microfilms or in any other physical way, and transmission or
information storage and retrieval, electronic adaptation, computer software, or by
similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service
marks, etc. in this publication does not imply, even in the absence of a specific
statement, that such names are exempt from the relevant protective laws and
regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and
information in this book are believed to be true and accurate at the date of
publication. Neither the publisher nor the authors or the editors give a warranty,
expressed or implied, with respect to the material contained herein or for any
errors or omissions that may have been made. The publisher remains neutral with
regard to jurisdictional claims in published maps and institutional affiliations.
v
vi Contents
Acetaminophen����������������������������������������������������������������������107
Kristin Brennan and Henry Liu
Nonsteroidal Anti-inflammatory Drugs (NSAIDs) ������������127
Kaivon Sobhani, Jinlei Li, and Milaurise Cortes
Anticonvulsants����������������������������������������������������������������������139
Efime Popovitz, Jinlei Li, and Nalini Vadivelu
Muscle Relaxants ������������������������������������������������������������������147
Clara Pau
Antidepressants����������������������������������������������������������������������159
Tolga Suvar
Alpha-2 Adrenergic Agonists������������������������������������������������169
Michael Guan, David Fanelli, Thomas Verbeek,
Dennis J. Warfield Jr., and Henry Liu
Ketamine ��������������������������������������������������������������������������������195
Sukhman Shergill and Nalini Vadivelu
Methadone������������������������������������������������������������������������������207
Jackson Condrey, Andrew Klein, and Carey Brewbaker
Buprenorphine, Buprenorphine/Naloxone
(Suboxone)������������������������������������������������������������������������������221
William F. Barrett and Carey Brewbaker
Complimentary Non-pharmacological
and Non-opioid Options��������������������������������������������������������239
Christopher D. Wolla and Tara Kelly
Acute Pain Management Protocol for Gastrointestinal
Procedures������������������������������������������������������������������������������475
Tolga Suvar and Henry R. Govekar
Acute Pain Management Protocol for Urological
Procedures: Kidney, Bladder, Prostate��������������������������������487
Poonam Pai, Jordan Abrams, and Yan H. Lai
Acute Pain Management Protocol
for Biliary-Hepatic, Spleen, Pancreatic Procedures ����������503
Elizabeth Cooney Reyes, Claire Marie Bentley,
Hong Wang, and Pete Pelletier
Acute Pain Management Protocol for Hernia Repair:
Umbilical, Inguinal, Femoral Hernia ����������������������������������521
Rutuja Sikachi and Yan H. Lai
Acute Pain Management Protocol in Major
Vascular Procedures��������������������������������������������������������������533
Ailan Zhang and Jeff L. Xu
Acute Pain Management Protocol in Minor
Vascular Procedures��������������������������������������������������������������575
Ashley Shilling, Matthew Thames, and Michael Glick
Acute Pain Management Protocol for Spine
Procedures������������������������������������������������������������������������������585
Jennifer Mardini, Shayann Ramedani, and Sonal Sharma
Must-Known Special Considerations for Acute
Pain Management in Pediatric Patient Population������������599
Jodi-Ann Oliver, Lori-Ann Oliver,
and Bartlomiej Bartkowiak
Must-Known Special Considerations for Acute
Pain Management in Geriatric Patient Population������������623
Thomas Halaszynski
Must-Known Special Considerations for Acute
Pain Management in Trauma and Non-OR Patients����������643
Brett Simmons and Nicole Hollis
Index����������������������������������������������������������������������������������������655
Contributors
ix
x Contributors
Key Question 1
What peripheral nerve blocks (PNBs) can be performed for this
patient? Compare and contrast single-shot versus continuous
methods. Which technique do you believe is best suited for this
patient?
PNBs can generally be administered by one of two possible tech-
niques: a one-time injection (i.e. “single-shot” or SSPNB) of local
anesthetic (LA), or a continuous infusion of LA via a percutaneously
placed catheter (CPNB). Each technique has distinct advantages and
disadvantages that should be carefully considered and thor-
oughly discussed with both the patient and the perioperative team.
CPNBs involve infusion of LA to a target nerve or nerve plexus
in an attempt to extend the benefits of SSPNB. CPNBs offer sev-
eral distinct advantages, particularly in the postoperative period.
Advantages of CPNBs are summarized in Table 1 based on a
plethora of research validating CPNBs in various surgical models,
particularly those related to orthopedics [1–3].
Despite these many advantages, CPNBs are also associated
with some drawbacks that have prevented them from being used
routinely. Catheter specific complications include [4–6]:
Key Question 2
During your preparation for the US-ISB catheter, a visiting medi-
cal student asks you what equipment/medications he/she
could help gather?
A principal means of delivering safe and effective local and
regional anesthesia involves maintaining a practice aimed at
avoiding adverse outcomes and preventing known complications.
Achieving this goal generally requires consistency on the part of
the anesthesiologist when it comes to preparation and basic setup
for every case.
Standard American Society of Anesthesiologist (ASA) moni-
tors, such as pulse oximetry, electrocardiography, and non-
invasive blood pressure measurement should be utilized for any
6 T. S. Lee and Y. H. Lai
Key Question 3
The medical student states that he has never seen a PNB per-
formed before, and asks how the ultrasound machine is able to
produce accurate and clinically useful images.
Safe Practice of Ultrasound Guided Regional Anesthesia 9
Case Stem Shortly before you begin the block, you discover that
the ultrasound machine is not functional and so you opt to per-
form the interscalene nerve catheter using peripheral nerve stimu-
lation.
dure may take slightly longer than usual and that the patient may
be in a significant amount of pain.
1 Summary
Common Pitfalls
Clinical Pearls
• Although the use of ultrasound has significantly reduced the
risk of complications, this risk has not been completely elimi-
nated.
• Under the appropriate clinical circumstances, CPNBs can be
an effective way to extend analgesia, facilitate earlier and
dynamic PT, and reduce overall hospital costs.
• When utilizing ultrasound guidance, it is imperative to select
the appropriate transducer and settings for a given procedure.
• While peripheral nerve stimulation can be an alternative to
ultrasound for nerve-localization, it can also be used to con-
firm ultrasound findings.
References
1. Bingham AE, Fu R, Horn JL, Abrahams MS. Continuous peripheral
nerve block compared with single-injection peripheral nerve block: a sys-
tematic review and meta-analysis of randomized controlled trials. Reg
Anesth Pain Med. 2012;37(6):583–94. https://doi.org/10.1097/
AAP.0b013e31826c351b.
2. Ilfeld BM. Continuous peripheral nerve blocks: an update of the pub-
lished evidence and comparison with novel, alternative analgesic modali-
ties. Anesth Analg. 2017;124(1):308–35. https://doi.org/10.1213/
ANE.0000000000001581.
3. Vorobeichik L, Brull R, Bowry R, Laffey JG, Abdallah FW. Should con-
tinuous rather than single-injection interscalene block be routinely
offered for major shoulder surgery? A meta-analysis of the analgesic and
side-effect profiles. Br J Anaesth. 2018;120(4):679–92. https://doi.
org/10.1016/j.bja.2017.11.104.
4. Marhofer D, Marhofer P, Triffterer L, Leonhardt M, Weber M, Zeitlinger
M. Dislocation rates of perineural catheters: a volunteer study. Br J
Anaesth. 2013;111(5):800–6. https://doi.org/10.1093/bja/aet198.
5. Bomberg H, Bayer I, Wagenpfeil S, Kessler P, Wulf H, Standl T, et al.
Prolonged catheter use and infection in regional anesthesia: a retrospec-
tive registry analysis. Anesthesiology. 2018;128(4):764–73. https://doi.
org/10.1097/ALN.0000000000002105.
6. Nouette-Gualain K, Capdevila X, Rossignol R. Local anesthetic ‘in-situ’
toxicity during peripheral nerve blocks: update on mechanisms and pre-
vention. Curr Opin Anaesthesiol. 2012;25(5):589–95. https://doi.
org/10.1097/ACO.0b013e328357b9e2.
Safe Practice of Ultrasound Guided Regional Anesthesia 17
* * * * *
* * * * *
106
Cf. above, p. 35.
107
The stele which bore this code of laws was discovered at Susa
in 1901–1902. The reign of Hammurabi is placed at about the
end of the third millennium b.c. There are translations of the
code by C. H. W. Johns (1903) and Robert Francis Harper
(1904).
108
“If a man owe a debt and Adad [god of storms] inundate his
field and carry away the produce, or, through lack of water,
grain have not grown in the field, in that year he shall not make
any return of grain to the creditor, he shall alter his contract-
tablet and he shall not pay the interest for that year.”—Code,
sec. 48. [We have used throughout Harper’s translation.]
109
Code, secs. 196, 197, 200. Cf. similar provisions of the Mosaic
code: Ex. xxi. 23–25; Deut. xix. 21.
110
Ibid. secs. 209, 210.
111
Ibid. secs. 229, 230.
112
The provisions read: “If a man aid a male or female slave of
the palace, or a male or female slave of a freeman to escape
from the city gate, he shall be put to death.”
“If a man harbor in his home a male or female slave who has
fled from the palace or from a freeman, and do not bring him
[the slave] forth at the call of the commandant, the owner of
that house shall be put to death” (Code, secs. 15, 16).
113
Maspero, The Dawn of Civilization, p. 744.
114
Taylor, Ancient Ideals (1896), vol. i, p. 41.
115
Records of the Past, New Series, vol. ii, pp. 143 ff.
116
“The white man has no doubt committed great barbarities upon
the savage, but he does not like to speak of them, and when
necessity compels a reference he has always something to
say of manifest destiny, the advance of civilization and the duty
of shouldering the white man’s burden in which he pays tribute
to a higher ethical conscience” (Hobhouse, Morals in Evolution
(1906), vol. i, p. 27). King Leopold may have been responsible
for barbarities committed against the natives of the Kongo as
atrocious as those of the Assyrians, but he paid tribute to the
modern conscience by refraining from portraying them in
imperishable marble at The Hague.
117
Cf. Martin, The Lore of Cathay (1901), p. 226.
118
Though the people are shut out from participation in the state
worship, they have set up for themselves a multitude of local
shrines where they worship the spirits of almost every earthly
thing, such as mountains, rivers, trees, and rocks. “Men
debarred from communion with the Great Spirit resorted more
eagerly to inferior spirits, to spirits of the fathers, and to spirits
generally.... The accredited worship of ancestors, with that of
the departed great added to it, was not enough to satisfy the
cravings of men’s minds.” (Legge, The Religions of China
(1881), p. 176).
119
The Lore of Cathay (1901), p. 274.
120
Williams, The Middle Kingdom (1883), vol. ii, p. 239.
121
We do not mention Buddhism in this connection for the reason
that it is not possible to trace any decisive influence, save in
the promotion of toleration, that this system has exercised
upon Chinese morality. Buddhism enjoins celibacy, and this,
like Christian asceticism, is in radical opposition to the genius
of Confucianism. For this reason, in conjunction with others,—
among these its early degeneracy,—Buddhism has remained
practically inert as an ethical force in Chinese society. What
little influence it has exerted has been confined almost wholly
to the monasteries.
122
“The dread of spirits is the nightmare of the Chinaman’s life.”—
Legge, The Religions of China (1881), p. 197.
123
The Religion of the Chinese (1910), p. 34.
124
The Taoist doctrines are contained in the Tao-teh-king,
supposed to have been written by Lao-tsze, a sage who lived
in the fifth century b.c. The religion which grew out of his
philosophy became in time degenerate, absorbed the worst
elements of Buddhism, and is to-day a system of gross
superstitions, magic, and sorcery, which has undeniably a
blighting effect upon morality.
125
De Groot, The Religion of the Chinese (1910), pp. 139 ff.
126
Ibid. 138.
127
Legge, The Religions of China (1881), p. 229.
128
De Groot, The Religion of the Chinese (1910), p. 143.
129
Nietzscheism is in essence at one with Taoism. Nietzsche
insists that man should behave as Nature behaves; for
instance, that the strong should prey upon the weak. The
difference between Lao-tsze and Nietzsche lies in their
different readings of the essential qualities of the universe. See
below, p. 355.
130
Taoism is too lofty a doctrine for the multitude. They are
enjoined to imitate the ancient sages, and as these imitated
the way of heaven and earth, in imitating them they are really
imitating the universe.
131
De Groot, The Religion of the Chinese (1910), p. 143.
132
The imitation of the qualities of nature “have given existence to
important state institutions, considered to be for the nation and
rulers matters of life and death.” (De Groot, The Religion of the
Chinese (1910), p. 139).
133
The Works of Mencius (The Chinese Classics, 2d ed., vol. ii),
bk. vi, pt. i, chap. ii, 2.
134
“This inference [that man is naturally good] comes into
prominence in the classics as a dogma, and therefore has
been the principal basis of all Taoistic and Confucian ethics to
this day” (De Groot, The Religion of the Chinese (1910), p.
137). Every schoolboy is taught this doctrine: “Man
commences life with a virtuous nature” (Martin, The Lore of
Cathay (1901), p. 217).
135
The Works of Mencius, bk. vii, pt. i, chap. ii, 2. And so
Confucius: “An accordance with this nature [man’s] is called
the Path of Duty” (The Doctrine of the Mean, chap. i; The
Chinese Classics, 2d ed., vol. i).
136
The Works of Mencius, bk. vi, pt. i, chap. vii, 2, 3.
137
Confucian Analects (The Chinese Classics, 2d ed., vol. i), bk.
xvii, chap. ii. The student of biology will see in this view an
anticipation of the latest teaching of modern science in respect
to the relative importance of heredity and education in the
determining of character.
138
“There is nothing in this world so dangerous for the national
safety, public health and welfare as heterodoxy, which means
acts, institutions, doctrines not based upon the classics.”—De
Groot, The Religion of the Chinese (1910), p. 48.
139
Confucius thus describes himself: “A transmitter and not a
maker, believing in and loving the ancients” (Confucian
Analects, bk. vii, chap. i).
140
The Religions of China (1881), p. 255.
141
Chinese literature bears unique testimony to the high
consideration in which the virtue of filial devotion and
reverence is held. It abounds in anecdotes exalting this virtue,
holding up great exemplars of it for imitation by the Chinese
youth. See Doolittle, Social Life of the Chinese.
142
The Hsiao King (Sacred Books of the East, vol. iii), chap. xviii.
143
Ibid. chap. xi.
144
Doolittle, Social Life of the Chinese (1868), p. 103.
145
Ibid. p. 103.
146
China in Law and Commerce (1905), p. 34.