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    Spotting For CCMP

    Uploaded by

    Sakshi Jain
    This document provides information on spotting questions for the subject of Clinical Chemistry and Medical Pathology (CCMP). It includes 4 spots each with 5 marks on fixed dose combinations, instruments, dosage forms, and adverse drug reactions. For fixed dose combinations, the spots require commenting on the justification, indications, contraindications/precautions, and adverse reactions. The instrument spots require identifying the instrument, its uses, and potentially disadvantages. The dosage form spots require identifying the form and 2 advantages and 2 disadvantages. The adverse drug reaction spots require identifying the reaction and the causative drug.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd

    Spotting For CCMP

    Uploaded by

    Sakshi Jain
    115 views62 pages
    This document provides information on spotting questions for the subject of Clinical Chemistry and Medical Pathology (CCMP). It includes 4 spots each with 5 marks on fixed dose combinations, instruments, dosage forms, and adverse drug reactions. For fixed dose combinations, the spots require commenting on the justification, indications, contraindications/precautions, and adverse reactions. The instrument spots require identifying the instrument, its uses, and potentially disadvantages. The dosage form spots require identifying the form and 2 advantages and 2 disadvantages. The adverse drug reaction spots require identifying the reaction and the causative drug.

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    Spotting for CCMP

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    This document provides information on spotting questions for the subject of Clinical Chemistry and Medical Pathology (CCMP). It includes 4 spots each with 5 marks on fixed dose combinations, instruments, dosage forms, and adverse drug reactions. For fixed dose combinations, the spots require commenting on the justification, indications, contraindications/precautions, and adverse reactions. The instrument spots require identifying the instrument, its uses, and potentially disadvantages. The dosage form spots require identifying the form and 2 advantages and 2 disadvantages. The adverse drug reaction spots require identifying the reaction and the causative drug.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    115 views62 pages

    Spotting For CCMP

    Uploaded by

    Sakshi Jain
    This document provides information on spotting questions for the subject of Clinical Chemistry and Medical Pathology (CCMP). It includes 4 spots each with 5 marks on fixed dose combinations, instruments, dosage forms, and adverse drug reactions. For fixed dose combinations, the spots require commenting on the justification, indications, contraindications/precautions, and adverse reactions. The instrument spots require identifying the instrument, its uses, and potentially disadvantages. The dosage form spots require identifying the form and 2 advantages and 2 disadvantages. The adverse drug reaction spots require identifying the reaction and the causative drug.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 62
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    The document discusses fixed dose combinations, medical instruments, their uses and adverse drug reactions caused by certain drugs.

    Fixed dose combinations (FDCs) are combinations of two or more active drugs in a fixed ratio. The document discusses several FDCs, their indications, contraindications and adverse reactions.

    Instruments described include disintegration time apparatus, dissolution time apparatus, metered dose inhaler, rotahaler and insulin pump. Their uses and some advantages/disadvantages are provided.

    Spotting for CCMP

    INSTRUCTIONS
    • TOTAL 4 SPOTS,5 MARKS EACH
    • TOTAL MARKS IN SPOTS 5×4=20
    DISTRIBUTION OF SPOTTING
    • 1 SPOT WILL BE KEPT FROM FDC
    • 1 SPOT FROM INTRUMENT
    • 1 SPOT FROM DOSAGE FORM
    • 2 FROM ADR
    Fixed dose combination
    FDC - 1
    • Comment on the following fixed dose
    formulation mentioning
    1) Justification of combination
    2) Indications
    3) Contraindication & precaution
    4) Adverse drug reaction
    Sulphamethoxazole400mg
    Trimethroprim 80 mg
    FDC - 2
    • Comment on the following fixed dose
    formulation mentioning
    1) Justification of combination
    2) Indications
    3) Contraindication
    4) Adverse drug reaction

    Amoxycillin 1gm +
    Potassium clavulanate 200 mg
    FDC - 3
    • Comment on the following fixed dose
    formulation mentioning
    1) Justification of combination
    2) Indication
    3) Contraindication
    4) Adverse drug reaction
    Levodopa 100 mg or 250 mg
    Carbidopa 10 mg or 25 mg
    FDC - 4
    • Comment on the following fixed dose
    formulation mentioning
    1) Justification of combination
    2) Indication
    3) Contraindication & precaution
    4) Adverse drug reaction
    Sulfadoxine 500mg +
    Pyrimethamine 25 mg
    FDC - 5
    • Comment on the following fixed dose
    formulation mentioning
    1) Justification of combination
    2) Indication
    3) Contraindication
    4) Adverse drug reaction
    Triamterine 50 mg + Benzthiazide 25
    mg
    Instruments
    SPOT 1
    Q. Identify the Instrument.
    Q. Write its uses
    Disintegration time apparatus
    Uses
    • Bioavailabilty study
    • For evaluation of disintegrate time of
    formulation
    • Determine whether tablets or capsules
    disintegrate within the prescribed time
    SPOT 2

    Q. Identify the
    Instrument.
    Q. Write its uses.
    Q. Write its
    disadvantages.
    Dissolution time apparatus:
    Uses :
    • Measure the rate & extent of
    dissolution or release of the drug
    substance from a drug product.
    • Evaluation of bioavailability
    • Batch to batch drug release uniformity
    • Development of more efficacious &
    therapeutically optimal dosage forms
    Dissolution time apparatus
    Disadvantage
    • Large volume of medium is required
    • Drug gets diluted & causes difficulties
    in analysis
    • Difficult to clean the cylinder.
    3.Metered dose inhaler
    • Identify the instrument.
    • Name the drug used in it.
    • Write its use.
    • Write advantages &
    disadvantages of it.
    3.Metered dose inhaler
    • Drugs used are Salbutamol, Budesonide,
    Fluticasone, Ipratropium
    • Use :
    -- Used to improve the drug delivery of
    aerosolized particles into the nasal
    passage ways & respiratory tract.
    Metered dose inhaler
    Advantages
    • It delivers specified amount of dose
    • Small size & convenience
    • Usually inexpensive as compare to dry
    powder inhalers & nebulizers
    • Quick to use
    Metered dose inhaler
    Disadvantages
    • Difficult to deliver high doses
    • There is no information about the
    number of doses left in the MDI.
    • Accurate co-ordination between
    actuation of a dose & inhalation is
    essential.
    4.Rotahaler
    • Identify the instrument.
    • Name the drug used in it.
    • Write its use.
    • Write advantages &
    disadvantages of it.
    4.Rotahaler
    • Used for treatment, control, prevention
    & improvement of Asthma & Bronchitis.
    • Drugs used are Salbutamol,
    Budesonide, Fluticasone, Ipratripium
    •
    Insulin Pump
    • Identify the instrument.
    • How does it work.
    • Write its use.
    • Write advantages &
    disadvantages of it
    Insulin Pump
    • Used an embedded sensor to measure
    blood sugar level at periodic interval &
    then inject insulin to maintain blood
    sugar level at a normal level.
    • It mimic the way the human pancreas
    works by delivering small doses of short
    acting insulin continuously.
    Dosage form
    SPOT 1
    1)Identify the Dosage form.
    2) Write 2 advantages & 2 disadvantages of
    given dosage form.
    Tablets
    1) Solid dasage form (tablet)
    2) Advantages
    -- Easy to administered
    -- Easy to be dispensed
    -- More stable dosage form
    -- Lighter and compact
    -- More stable and economical dosage
    form
    Tablets
    • Disadvantages
    -- slow onset of action is comparable to
    parenteral liquid oral & capsules
    -- Difficult to swallow for kids, terminally ill
    & geriatic patient
    -- Drugs not absorbed or extensively
    degraded into GI tract cannot be made in
    tablets
    SPOT 2
    • Identify the Dosage form.
    • Write 2 advantages & 2 disadvantages of
    given dosage form.
    Solid dasage form (capsules)
    Capsules
    SPOT 3
    • Identify the Dosage form.
    • Write 2 advantages & 2 disadvantages of
    IV route.
    Ampoule
    SPOT 4
    • Identify the Dosage form.
    • Write 2 advantages & 2 disadvantages
    of IV route.
    Vial
    ADR
    DEFINITION OF ADR
    • It is defined as noxious, undesired or
    unintended effect of a drug which may occur
    at doses normally used in man for various
    purposes(prophylactic,diagnostic,therapeutic)
    or for the modification of the physiological
    state
    SPOT
    IDENTIFY ADR?
    NAME THE DRUG CAUSING IT?
    • Cleft lip
    • Phenytoin ,Methotrexate
    SPOT
    IDENTIFY ADR?
    NAME THE DRUG CAUSING IT?
    • Floppy baby syndrome
    • Benzodiazepines
    SPOT
    IDENTIFY ADR?
    NAME THE DRUG CAUSING IT?
    • Buffalo hump:cushings
    • corticosteriod
    SPOT
    IDENTIFY ADR?
    NAME THE DRUG CAUSING IT?
    • Phocomelia
    • thalidomide
    SPOT
    IDENTIFY ADR?
    NAME THE DRUG CAUSING IT?
    • Hydrocephalous
    • Anticancer, isotretinoin
    SPOT
    IDENTIFY ADR?
    NAME THE DRUG CAUSING IT?
    • Alopecia
    • Anticancer drugs
    SPOT
    IDENTIFY ADR?
    NAME THE DRUG CAUSING IT?
    • Neural tube defect
    • Sodium valproate
    SPOT
    IDENTIFY ADR?
    NAME THE DRUG CAUSING IT?
    • Gynaecomastia
    • Cimetidine, Methyldopa
    SPOT
    IDENTIFY ADR?
    NAME THE DRUG CAUSING IT?
    • Epidermal necrolysis
    • sulfonamides
    SPOT
    IDENTIFY ADR?
    NAME THE DRUG CAUSING IT?
    • Steven johnson syndrome
    • sulphonamides

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