Bone

Bones: Tissue and Organ
• Bones can be referred to as either a tissue (osseous)

or an organ
– Bone referred to as a connective tissue consists of:
• cells
• extracellular matrix (ground substance + fibers)
• this living/dynamic tissue is capable of growth
and repair
– Bone referred to as an organ (particular bones of
the body) consists of:
• osseous tissue
• nervous tissue
• epithelial and muscle tissue (blood vessels)
• Ex. femur, humerus, clavicle, sternum…
Skeletal System
Function of Bones
• Support
– form the framework that supports the body
• Protection
– provide a protective cavity for the brain (skull),
spinal cord (vertebrae), and vital organs (rib cage)
• Movement
– provide attachment points for skeletal muscles and
are used as levers
• Mineral storage
– reservoir for calcium and phosphorus
• Blood cell formation (hemopoiesis)
– occurs within the red bone marrow of bones
Shapes of Bones
Gross Anatomy of Bones: Bone Textures
• Compact bone
– dense and heavy bone
• Spongy bone
– porous and light bone
– formed by rods and plates of bone called trabeculae
– spaces filled with red bone marrow
– provides strength with little weight
• The bones of the body contain both bone textures
– the outer layer is made of compact bone
– the inner portion of bones is made of spongy bone
Compact and Spongy bone
Structure of Long
Bones
Structure of Long Bones
• Diaphysis
– tubular shaft of compact bone that surrounds the
medullary cavity
• during growth periods contains red bone marrow
• in adults, contains yellow bone marrow (fat)
• Epiphyses
– expanded ends of long bones
– exterior is compact bone, and the interior is spongy
bone
– superficial surface covered in articular (joint)
cartilage
– epiphyseal plate (line) separates the diaphysis from
the epiphyses and represents location of bone
lengthening (growth)
Cells of Osseous Tissue
• Osteoblasts
– found in periosteum and endosteum
– cells that make (deposit) the matrix of osseous
tissue
– increase bone density
• Osteoclasts
– found in periosteum and endosteum
– cells that break down (resorb) the matrix of osseous
tissue
– decrease bone density
• Osteocytes
– cells that are surrounded by matrix (located in a
lacunae) that are not depositing or resorbing matrix
Composition of Bone (Extracellular) Matrix
• Inorganic components
– hydroxyapatites
• calcium and phosphate deposits
• 65% of bone by mass
• responsible for bone hardness
• Fibers
– collagen
• provides an ability of bone to flex slightly without
fracturing
Histology
of Bone
Bone Histology
• The basic structural unit of bone is called the osteon
(haversian system)
– a central canal holding blood vessels and nerves
that are parallel to the longest dimension of the
bone is surrounded concentric cylinders of bone
called lamellae
– osteocytes found between lamellae are connected
to each other by tiny cracks in the lamellae called
canaliculi
• Perforating canals
– canals that are perpendicular to the central canals
joining them to the blood and nerve supply at the
superficial surface of the bone
Osteon of Compact Bone
Coverings of Bone
• There are 2 surfaces of a bone that are covered with a

thin layer of connective tissue
– the most superficial surface is covered by the
periosteum
– the internal surface of the central and perforating
canals is covered with endosteum
• Both the periosteum and the endosteum contain
osteoblasts and osteoclasts which are capable of
increasing and decreasing the amount of bone tissue
– bone remodeling
Joints (Articulations)
• Site where two or more bones meet

• Weakest parts of the skeleton
• Functions include:
– provide mobility for the skeleton
• bones move in relation to one another where the
joints serve as a fulcrum (pivot point) and the
associated bones serve as levers
– hold the skeleton together
Classification of Joints
• The three functional classes of joints are:
– Synarthroses
• immovable
– Amphiarthroses
• slightly movable
– Diarthroses
• freely movable
• The three structural classifications are:
– Synovial
– Fibrous
– Cartilaginous
Synovial Joints
• Those joints in which the articulating bones are

separated by a joint capsule filled with synovial fluid
– all are freely movable (diarthroses)
– found mainly in arm and legs
Cartilaginous Joints
• Articulating bones are

united by cartilage
– most are slightly
movable
(amphiarthroses)
– include intervertebral
discs
Fibrous Joints
• The bones are joined

by dense connective
tissue containing a
high amount of
collagen
– most are
immovable
(synarthroses)
– include the bones
of the skull

Bone

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Bones: Tissue and Organ

• Bones can be referred to as either a tissue (osseous)

• There are 2 surfaces of a bone that are covered with a

• Site where two or more bones meet

• Those joints in which the articulating bones are

• Articulating bones are

• The bones are joined

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