tumor protein p53 (Q283350)

From Wikidata
Jump to navigation Jump to search
mammalian protein found in Homo sapiens
  • Tumor suppressor p53
  • transformation-related protein 53
  • tumor supressor p53
  • TP53
  • mutant tumor protein 53
  • p53 tumor suppressor
  • antigen NY-CO-13
  • phosphoprotein p53
  • Tumor Suppressor Protein p53
  • cellular tumor antigen p53
  • tumor protein 53
  • p53
edit
Language Label Description Also known as
English
tumor protein p53
mammalian protein found in Homo sapiens
  • Tumor suppressor p53
  • transformation-related protein 53
  • tumor supressor p53
  • TP53
  • mutant tumor protein 53
  • p53 tumor suppressor
  • antigen NY-CO-13
  • phosphoprotein p53
  • Tumor Suppressor Protein p53
  • cellular tumor antigen p53
  • tumor protein 53
  • p53

Statements

image
P53.png
840 × 1,096; 747 KB
0 references
has effect
DNA repair
0 references
molecular function
enzyme binding
determination method or standard
IPI
8 references
retrieved
8 April 2019
stated in
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Aprataxin, a novel protein that protects against genotoxic stress
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 modulation of TFIIH–associated nucleotide excision repair activity
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 is regulated by the lysine demethylase LSD1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
protein binding
determination method or standard
IPI
310 references
retrieved
8 April 2019
stated in
MOZ increases p53 acetylation and premature senescence through its complex formation with PML
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Induction of SOX4 by DNA damage is critical for p53 stabilization and function
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
RNF125 is a ubiquitin-protein ligase that promotes p53 degradation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
ASPP proteins specifically stimulate the apoptotic function of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Disruption of FAT10-MAD2 binding inhibits tumor progression.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
USP10 regulates p53 localization and stability by deubiquitinating p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular basis of Pirh2-mediated p53 ubiquitylation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Binding and modulation of p53 by p300/CBP coactivators
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The notch regulator MAML1 interacts with p53 and functions as a coactivator
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modulation of p53 function by SET8-mediated methylation at lysine 382
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Trim24 targets endogenous p53 for degradation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Arginine methylation regulates the p53 response
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
BRD7 is a candidate tumour suppressor gene required for p53 function
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
High mobility group protein-1 (HMG-1) is a unique activator of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
G9a and Glp methylate lysine 373 in the tumor suppressor p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nucleophosmin regulates the stability and transcriptional activity of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of p53 tetramerization and nuclear export by ARC
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Repression of p53 activity by Smyd2-mediated methylation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Critical role for Daxx in regulating Mdm2
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel cofactor for p300 that regulates the p53 response
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of p53 activity in nuclear bodies by a specific PML isoform
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 modulation of TFIIH–associated nucleotide excision repair activity
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Wild-type p53 binds to the TATA-binding protein and represses transcription
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 has a direct apoptogenic role at the mitochondria
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Monoubiquitylation promotes mitochondrial p53 translocation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of p53 with the Human Rad51 Protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural features of human histone acetyltransferase p300 and its complex with p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of XIAP translation and induction by MDM2 following irradiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
RYBP stabilizes p53 by modulating MDM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 Modulates the exonuclease activity of Werner syndrome protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The DNA-binding domain mediates both nuclear and cytosolic functions of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 is regulated by the lysine demethylase LSD1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Trim24 targets endogenous p53 for degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
An acetyl-methyl switch drives a conformational change in p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Wild-type p53 controls cell motility and invasion by dual regulation of MET expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
BRD7 is a candidate tumour suppressor gene required for p53 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Twist and p53 reciprocally regulate target genes via direct interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Evidence for self-association of the alternative sigma factor σ54
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
High mobility group protein-1 (HMG-1) is a unique activator of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Fludarabine treatment favors the retention of miR-485-3p by prostate cancer cells: implications for survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Turning the RING domain protein MdmX into an active ubiquitin-protein ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 has a direct apoptogenic role at the mitochondria
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDM4 binds ligands via a mechanism in which disordered regions become structured
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition of p53 DNA binding by human papillomavirus E6 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The yeast two-hybrid system reveals no interaction between p73 alpha and SV40 large T-antigen
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NUMB controls p53 tumour suppressor activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for the methylation site specificity of SET7/9
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular basis of Pirh2-mediated p53 ubiquitylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis of substrate methylation and inhibition of SMYD2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular recognition of p53 and MDM2 by USP7/HAUSP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Acetylation is indispensable for p53 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Synergistic activation of transcription by CBP and p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
DBC1 is a negative regulator of SIRT1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modulation of the vitamin D3 response by cancer-associated mutant p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
PACT is a negative regulator of p53 and essential for cell growth and embryonic development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
S100 proteins interact with the N-terminal domain of MDM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 opens the mitochondrial permeability transition pore to trigger necrosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nucleophosmin regulates the stability and transcriptional activity of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of p53 tetramerization and nuclear export by ARC
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Viral immune modulators perturb the human molecular network by common and unique strategies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Negative regulation of p53 functions by Daxx and the involvement of MDM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Skp2B attenuates p53 function by inhibiting prohibitin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
AtBAG6, a novel calmodulin-binding protein, induces programmed cell death in yeast and plants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Critical role for Daxx in regulating Mdm2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tail
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of the translationally controlled tumor protein in DNA damage sensing and repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inactivation of the p53 pathway in retinoblastoma.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Differential effect of ik3-1/cables on p53- and p73-induced cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The central region of HDM2 provides a second binding site for p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
S100A4 interacts with p53 in the nucleus and promotes p53 degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
TSPYL5 suppresses p53 levels and function by physical interaction with USP7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mitogen-activated Protein Kinase Kinase 2 (MEK2), a Novel E2-interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of metallothionein with tumor suppressor p53 protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Aprataxin, a novel protein that protects against genotoxic stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel cofactor for p300 that regulates the p53 response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 modulates RPA-dependent and RPA-independent WRN helicase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 Stabilization and accumulation induced by human vaccinia-related kinase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of p53 activity through lysine methylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Induction of SOX4 by DNA damage is critical for p53 stabilization and function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ectodermal factor restricts mesoderm differentiation by inhibiting p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Theaflavins retard human breast cancer cell migration by inhibiting NF-kappaB via p53-ROS cross-talk.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Novel nucleolar pathway connecting intracellular energy status with p53 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of p53 stability and function by the deubiquitinating enzyme USP42
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Negative regulation of the deacetylase SIRT1 by DBC1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 mediates the negative regulation of MDM2 by orphan receptor TR3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Physical interaction and mutual transrepression between CCAAT/enhancer-binding protein beta and the p53 tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
TOE1 interacts with p53 to modulate its transactivation potential
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modulation of microRNA processing by p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
SAFB1 interacts with and suppresses the transcriptional activity of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
In silico prediction of physical protein interactions and characterization of interactome orphans
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Surface plasmon resonance imaging protein arrays for analysis of triple protein interactions of HPV, E6, E6AP, and p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of p53 unbound to T-antigen in human cells transformed by simian virus 40 T-antigen
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Repression of p53 activity by Smyd2-mediated methylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein-protein interactions among human lens acidic and basic beta-crystallins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
PRAK is essential for ras-induced senescence and tumor suppression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 is regulated by the lysine demethylase LSD1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Physical and functional interaction between HCV core protein and the different p73 isoforms
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
identical protein binding
determination method or standard
IPI
9 references
retrieved
28 February 2017
stated in
In silico prediction of physical protein interactions and characterization of interactome orphans
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IPI
retrieved
28 February 2017
stated in
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IPI
retrieved
28 February 2017
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IPI
retrieved
28 February 2017
stated in
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IPI
retrieved
28 February 2017
stated in
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IPI
retrieved
28 February 2017
stated in
Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IPI
retrieved
28 February 2017
stated in
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IPI
retrieved
28 February 2017
stated in
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IPI
retrieved
28 February 2017
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IPI
ubiquitin protein ligase binding
determination method or standard
IPI
5 references
retrieved
1 January 2018
stated in
Identification of a novel gene encoding a p53-associated protein
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
1 January 2018
stated in
CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
1 January 2018
stated in
CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
1 January 2018
stated in
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
1 January 2018
stated in
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
DNA binding
determination method or standard
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
8 April 2019
stated in
Binding of natively unfolded HIF-1alpha ODD domain to p53
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method or standard
IDA
ISA
ISM
NAS
6 references
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
NAS
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
ISM
retrieved
8 April 2019
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
ISA
retrieved
8 April 2019
stated in
DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
identical protein binding
determination method or standard
IMP
IPI
19 references
retrieved
8 April 2019
stated in
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ultraslow oligomerization equilibria of p53 and its implications
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
In silico prediction of physical protein interactions and characterization of interactome orphans
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Core domain interactions in full-length p53 in solution
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of p53 tetramerization and nuclear export by ARC
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Binding of natively unfolded HIF-1alpha ODD domain to p53
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
ubiquitin protein ligase binding
determination method or standard
IEA
IPI
6 references
retrieved
8 April 2019
stated in
CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of a novel gene encoding a p53-associated protein
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
cell component
cytoplasm
determination method or standard
IDA
IEA
7 references
retrieved
28 February 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IEA
retrieved
28 February 2017
stated in
USP10 regulates p53 localization and stability by deubiquitinating p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
p53 isoforms can regulate p53 transcriptional activity.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Direct involvement of p53 in programmed cell death of oligodendrocytes
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Regulation of human p53 activity and cell localization by alternative splicing
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
nucleus
determination method or standard
IDA
IEA
16 references
retrieved
28 February 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IEA
retrieved
28 February 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IEA
retrieved
28 February 2017
stated in
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
USP10 regulates p53 localization and stability by deubiquitinating p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Direct involvement of p53 in programmed cell death of oligodendrocytes
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
p53 isoforms can regulate p53 transcriptional activity.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Myosin VI is a mediator of the p53-dependent cell survival pathway.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Induction of SOX4 by DNA damage is critical for p53 stabilization and function
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Regulation of human p53 activity and cell localization by alternative splicing
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
retrieved
28 February 2017
stated in
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
determination method or standard
IDA
nucleus
determination method or standard
IDA
IEA
IMP
17 references
retrieved
8 April 2019
stated in
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
USP10 regulates p53 localization and stability by deubiquitinating p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Direct involvement of p53 in programmed cell death of oligodendrocytes
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Induction of SOX4 by DNA damage is critical for p53 stabilization and function
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Arginine methylation regulates the p53 response
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Myosin VI is a mediator of the p53-dependent cell survival pathway.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
cytoplasm
determination method or standard
IDA
IEA
IMP
10 references
retrieved
8 April 2019
stated in
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
USP10 regulates p53 localization and stability by deubiquitinating p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Direct involvement of p53 in programmed cell death of oligodendrocytes
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Arginine methylation regulates the p53 response
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
p53 isoforms can regulate p53 transcriptional activity.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Deacetylation of p53 induces autophagy by suppressing Bmf expression
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
biological process
positive regulation of transcription, DNA-templated
determination method or standard
IDA
IMP
5 references
retrieved
1 January 2018
stated in
USP10 regulates p53 localization and stability by deubiquitinating p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
1 January 2018
stated in
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
1 January 2018
stated in
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
1 January 2018
stated in
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
1 January 2018
stated in
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
positive regulation of transcription by RNA polymerase II
determination method or standard
IDA
IGI
IMP
10 references
retrieved
1 January 2018
stated in
Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
1 January 2018
stated in
RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
1 January 2018
stated in
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IGI
retrieved
1 January 2018
stated in
DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
1 January 2018
stated in
Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
1 January 2018
stated in
CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
1 January 2018
stated in
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
1 January 2018
stated in
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
1 January 2018
stated in
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
1 January 2018
stated in
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
cellular response to DNA damage stimulus
determination method or standard
IDA
IEA
IMP
5 references
retrieved
8 April 2019
stated in
Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
determination method or standard
IDA
IEA
IMP
5 references
retrieved
8 April 2019
stated in
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
positive regulation of transcription, DNA-templated
determination method or standard
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
USP10 regulates p53 localization and stability by deubiquitinating p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
positive regulation of transcription by RNA polymerase II
determination method or standard
IDA
IEA
IGI
IMP
11 references
retrieved
8 April 2019
stated in
Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
8 April 2019
stated in
RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IMP
retrieved
8 April 2019
stated in
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IEA
retrieved
8 April 2019
stated in
DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
retrieved
8 April 2019
stated in
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IDA
Commons category
Tumor suppressor protein p53
1 reference
imported from Wikimedia project
English Wikipedia

Identifiers

MeSH descriptor ID
D016159
subject named as
Tumor Suppressor Protein p53
0 references
MeSH tree code
D12.776.157.687.650
0 references
D12.776.260.820
0 references
D12.776.624.776.775
0 references
D12.776.660.720.650
0 references
D12.776.744.845
0 references
Ensembl protein ID
PDB structure ID
 
edit
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                Retrieved from "https://www.wikidata.org/w/index.php?title=Q283350&oldid=2158096277"