Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK (Q33922223)

25036776

30 July 2017

title

Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK (English)

1 reference

30 July 2017

1

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Marc Foretz

2

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Laurent Bultot

3

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Benoit Viollet

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Bruce Ernest Kemp

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Kei Sakamoto

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author name string

Morgan D Fullerton

4

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Fiona A Ross

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12 June 2020

Simon A Hawley

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Natalia Shpiro

8

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Denis Barron

10

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12 June 2020

Gregory R Steinberg

12

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D Grahame Hardie

13

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Maria Deak

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publication date

1 July 2014

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25036776

30 July 2017

published in

Chemistry and Biology

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volume

21

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issue

7

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12 June 2020

page(s)

866-879

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A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis

12 June 2020

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5 July 2018

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5 July 2018

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

5 July 2018

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5 July 2018

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5 July 2018

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Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

5 July 2018

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5 July 2018

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Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

5 July 2018

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5 July 2018

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5 July 2018

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A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake

5 July 2018

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Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

29 October 2018

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ATP sensitive bi-quinoline activator of the AMP-activated protein kinase.

29 October 2018

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Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice.

29 October 2018

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Coordinated regulation of AMPK activity by multiple elements in the α-subunit

29 October 2018

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AMPK is a direct adenylate charge-regulated protein kinase.

29 October 2018

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Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

29 October 2018

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Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

29 October 2018

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5-Aminoimidazole-4-carboxamide 1-beta -D-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms

29 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25036776

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2014.05.014

1 reference

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12 June 2020

1 reference

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12 June 2020

25036776

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25036776%20AND%20SRC:MED&resulttype=core&format=json