Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing (Q97692894)

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26 July 2020

title

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing (English)

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Eugenia Trushina

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Cecilie Morland

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Alessandro Prigione

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Anne Eckert

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Jack H Jhamandas

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Oliver Kann

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William F. Martin

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Paula I. Moreira

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Michael P. Murphy

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Klaus-Armin Nave

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Frédéric Saudou

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Mark Mattson

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Linda H Bergersen

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M Flint Beal

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26 July 2020

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Gemma Casadesus

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Roberta D Brinton

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26 July 2020

Suzanne de la Monte

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Jenni Harvey

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Ross Jeggo

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26 July 2020

Clothide Mannoury la Cour

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Gilles Mithieux

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Tal Nuriel

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26 July 2020

Stéphane H R Oliet

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26 July 2020

Russell H Swerdlow

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Mark J Millan

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26 July 2020

publication date

24 July 2020

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Nature Reviews Drug Discovery

26 July 2020

published in

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Microglia-Specific Metabolic Changes in Neurodegeneration

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7 January 2021

A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer's Disease: Preliminary Results from a Neuroimaging Study

1 reference

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7 January 2021

The role of type 2 diabetes in neurodegeneration

1 reference

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7 January 2021

Perimenopause as a neurological transition state

1 reference

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7 January 2021

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology

1 reference

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7 January 2021

Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention

1 reference

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7 January 2021

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

1 reference

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7 January 2021

Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response

1 reference

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7 January 2021

Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

1 reference

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7 January 2021

Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function

1 reference

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7 January 2021

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

1 reference

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7 January 2021

Medium-chain triglycerides improved cognition and lipid metabolomics in mild to moderate Alzheimer's disease patients with APOE4-/-: A double-blind, randomized, placebo-controlled crossover trial

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The genetic architecture of mitochondrial dysfunction in Parkinson's disease

1 reference

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7 January 2021

The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4

1 reference

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7 January 2021

Metabolic Dysregulation in Amyotrophic Lateral Sclerosis: Challenges and Opportunities

1 reference

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7 January 2021

FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations

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7 January 2021

Neuroketotherapeutics: A modern review of a century-old therapy

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7 January 2021

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

1 reference

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7 January 2021

Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease

1 reference

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7 January 2021

Mitochondrial dynamics and transport in Alzheimer's disease

1 reference

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7 January 2021

Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan.

1 reference

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7 January 2021

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

AMPK: guardian of metabolism and mitochondrial homeostasis.

1 reference

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7 January 2021

Disturbed mitochondrial dynamics and neurodegenerative disorders

1 reference

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7 January 2021

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity

1 reference

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7 January 2021

Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease.

1 reference

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7 January 2021

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

1 reference

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7 January 2021

A Mitochondrial Biomarker-Based Study of S-Equol in Alzheimer's Disease Subjects: Results of a Single-Arm, Pilot Trial

1 reference

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7 January 2021

2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease

1 reference

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7 January 2021

PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

1 reference

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7 January 2021

Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

1 reference

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7 January 2021

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

1 reference

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7 January 2021

NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

1 reference

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7 January 2021

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease

1 reference

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7 January 2021

Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure.

1 reference

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7 January 2021

Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases

1 reference

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7 January 2021

Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease

1 reference

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7 January 2021

Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons

1 reference

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7 January 2021

Rapid adaptation of rat brain and liver metabolism to a ketogenic diet: an integrated study using (1)H- and (13)C-NMR spectroscopy

1 reference

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7 January 2021

Plasma Ketone and Medium Chain Fatty Acid Response in Humans Consuming Different Medium Chain Triglycerides During a Metabolic Study Day

1 reference

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7 January 2021

Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Reduced severity of ischemic stroke and improvement of mitochondrial function after dietary treatment with the anaplerotic substance triheptanoin

1 reference

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7 January 2021

Triheptanoin for the treatment of brain energy deficit: A 14-year experience

1 reference

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7 January 2021

Heptanoate as a neural fuel: energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain

1 reference

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7 January 2021

A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Dietary ketosis enhances memory in mild cognitive impairment

1 reference

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7 January 2021

Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease.

1 reference

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7 January 2021

Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer's disease

1 reference

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7 January 2021

Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies

1 reference

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7 January 2021

Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial

1 reference

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7 January 2021

Preliminary Report on the Feasibility and Efficacy of the Modified Atkins Diet for Treatment of Mild Cognitive Impairment and Early Alzheimer's Disease

1 reference

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7 January 2021

A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Effects of beta-hydroxybutyrate on cognition in memory-impaired adults

1 reference

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7 January 2021

Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Upregulation of GPR109A in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Metabolism and epilepsy: Ketogenic diets as a homeostatic link

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Metabolic and Cognitive Outcomes of Subchronic Once-Daily Intranasal Insulin Administration in Healthy Men

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The Therapeutic Potential of Metformin in Neurodegenerative Diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Metformin selectively targets redox control of complex I energy transduction

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The mechanisms of action of metformin

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

GDF15 mediates the effects of metformin on body weight and energy balance

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Corrigendum: Evaluation of Metformin on Cognitive Improvement in Patients With Non-dementia Vascular Cognitive Impairment and Abnormal Glucose Metabolism

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Increased risk of cognitive impairment in patients with diabetes is associated with metformin

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Semaglutide seems to be more effective the other GLP-1Ras

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Semaglutide: Review and Place in Therapy for Adults With Type 2 Diabetes

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Glucagon like peptide-1 (GLP-1) likes Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Vildagliptin Attenuates Huntington's Disease through Activation of GLP-1 Receptor/PI3K/Akt/BDNF Pathway in 3-Nitropropionic Acid Rat Model

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Post hoc analysis of the Exenatide-PD trial-Factors that predict response

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

DPP4 Inhibitors Can Be a Drug of Choice for Type 3 Diabetes: A Mini Review

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The effects of sitagliptin, a DPP-4 inhibitor, on cognitive functions in elderly diabetic patients with or without Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Effect of D-Ala2GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Ghrelin-mediated improvements in the metabolic phenotype in the R6/2 mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer's Disease.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Ghrelin mediated neuroprotection - A possible therapy for Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

A randomized trial of relamorelin for constipation in Parkinson's disease (MOVE-PD): Trial results and lessons learned

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

A Leptin Fragment Mirrors the Cognitive Enhancing and Neuroprotective Actions of Leptin.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The Adiponectin Homolog Osmotin Enhances Neurite Outgrowth and Synaptic Complexity via AdipoR1/NgR1 Signaling in Alzheimer's Disease.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Amylin and Leptin: Co-Regulators of Energy Homeostasis and Neuronal Development

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer's Disease Are Associated with Oxidative Stress Regulation Mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer's Disease Mouse Model.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Intermediates of Metabolism: From Bystanders to Signalling Molecules.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The impact of histone post-translational modifications in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Alzheimer's Disease and Histone Code Alterations.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Lactate Mediates the Effects of Exercise on Learning and Memory through SIRT1-Dependent Activation of Hippocampal Brain-Derived Neurotrophic Factor (BDNF)

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Gene-Based Approaches to Inherited Neurometabolic Diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

How to reprogram microglia toward beneficial functions

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

One decade ago, one decade ahead in huntington's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Gene Therapy for ALS-A Perspective

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Targeting α-Synuclein in Parkinson's Disease: Progress Towards the Development of Disease-Modifying Therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Gene therapy for neurological disorders: progress and prospects

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

AVXS-101 (Onasemnogene Abeparvovec) for SMA1: Comparative Study with a Prospective Natural History Cohort

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Gene therapy for Glut1-deficient mouse using an adeno-associated virus vector with the human intrinsic GLUT1 promoter.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Gene therapy targeting mitochondrial pathway in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The Potential of CRISPR/Cas9 Gene Editing as a Treatment Strategy for Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

ApoE4: an emerging therapeutic target for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Increased translation as a novel pathogenic mechanism in Huntington's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Treating cognitive impairment with transcranial low level laser therapy

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Shining light on the head: Photobiomodulation for brain disorders

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Transcranial low-level laser therapy improves brain mitochondrial function and cognitive impairment in D-galactose-induced aging mice.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in Dementia Patients Testing Memory and Cognition

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Advances in Management of Neuropsychiatric Syndromes in Neurodegenerative Diseases

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7 January 2021

Multi-Target Directed Drugs as a Modern Approach for Drug Design Towards Alzheimer's Disease: an update

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Impairments in Oxidative Glucose Metabolism in Epilepsy and Metabolic Treatments Thereof

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

N-acetylcysteine protects memory decline induced by streptozotocin in mice

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Triheptanoin Protects Motor Neurons and Delays the Onset of Motor Symptoms in a Mouse Model of Amyotrophic Lateral Sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Triheptanoin improves brain energy metabolism in patients with Huntington disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15 years Experience

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Uniform distributions of glucose oxidation and oxygen extraction in gray matter of normal human brain: No evidence of regional differences of aerobic glycolysis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Glia-neuron energy metabolism in health and diseases: New insights into the role of nervous system metabolic transporters

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Metabolic modulation of neuronal gamma-band oscillations

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

18F-FDG Is a Superior Indicator of Cognitive Performance Compared to 18F-Florbetapir in Alzheimer's Disease and Mild Cognitive Impairment Evaluation: A Global Quantitative Analysis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Physical activity and muscle-brain crosstalk

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Comparative efficacy and acceptability of antidiabetic agents for Alzheimer's disease and mild cognitive impairment: A systematic review and network meta-analysis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Adult Neurogenic and Antidepressant Effects of Adiponectin: A Potential Replacement for Exercise?

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Influence of young adult cognitive ability and additional education on later-life cognition

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

How the cognitive reserve interacts with β-amyloid deposition in mitigating FDG metabolism: An observational study

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

HIV-1 infection alters energy metabolism in the brain: Contributions to HIV-associated neurocognitive disorders

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

FDG-PET in Creutzfeldt-Jakob disease: Analysis of clinical-PET correlation

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Alterations in neuronal metabolism contribute to the pathogenesis of prion disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Stroke management - recent advances and residual challenges

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Imaging the Effects of β-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Aiming for the target: Mitochondrial drug delivery in traumatic brain injury

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Ketogenic diet prevents alterations in brain metabolism in young but not adult rats after traumatic brain injury.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Role of Hypertonic Sodium Lactate in Traumatic Brain Injury Management

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The glucose transporter type 1 (Glut1) syndromes

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Evidence for impaired glucose metabolism in the striatum, obtained postmortem, from some subjects with schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Ketogenic diet reverses behavioral abnormalities in an acute NMDA receptor hypofunction model of schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Ketogenic diet for schizophrenia: Nutritional approach to antipsychotic treatment

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Ketogenic diet in the treatment of schizoaffective disorder: Two case studies

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

The metabolic face of migraine - from pathophysiology to treatment

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

Retinal metabolism: A comparative look at energetics in the retina

1 reference

https://api.crossref.org/works/10.1038%2FS41573-020-0072-X

7 January 2021

10.1038/S41573-020-0072-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32709961%20AND%20SRC:MED&resulttype=core&format=json

26 July 2020

1 reference