호모 사피엔스 종의 단백질 코드 유전자
ATP 합성효소 서브유닛 g, 미토콘드리아 는 사람에게서 ATP5MG [5] [6] [7] 효소 이다.
미토콘드리아 ATP 합성효소는 산화적 인산화 동안 내막을 가로지르는 양성자의 전기 화학적 구배를 이용하여 ATP 합성을 촉매한다. 용해성 촉매 코어 F1과 양성자 채널을 구성하는 막 스패닝 성분 Fo라는 두 개의 연결된 다중 서브유닛 복합체로 구성됩니다. F1 복합체는 3 알파, 3 베타 비율로 조립된 5개의 서로 다른 서브 유닛(알파, 베타, 감마, 델타, 엡실론)과 나머지 3개의 단일 대표로 구성된다. Fo에는 9개의 서브유닛(a, b, c, d, e, f, g, F6, 및 8)이 있는 것 같습니다. 이 유전자는 F0 [7]
서브유닛 G의 기능은 현재 알려져 있지 않다. 지금까지 [8] 세균성 F-ATP에는 대응 물질이 없다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000167283 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000038717 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells" . Genome Res . 10 (10): 1546–60. doi :10.1101/gr.140200 . PMC 310934 PMID 11042152 . ^ a b "Entrez Gene: ATP5MG ATP synthase membrane subunit g" .^ Collinson IR, Runswick MJ, Buchanan SK, Fearnley IM, Skehel JM, van Raaij MJ, Griffiths DE, Walker JE (June 1994). "Fo membrane domain of ATP synthase from bovine heart mitochondria: purification, subunit composition, and reconstitution with F1-ATPase". Biochemistry . 33 (25): 7971–8. doi :10.1021/bi00191a026 . PMID 8011660 . 외부 링크 추가 정보 Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine". Essays Biochem . 35 : 3–18. doi :10.1042/bse0350003 . PMID 12471886 . Oster G, Wang H (2003). "Rotary protein motors". Trends Cell Biol . 13 (3): 114–21. doi :10.1016/S0962-8924(03)00004-7 . PMID 12628343 . Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)". Mol. Membr. Biol . 20 (1): 27–33. doi :10.1080/0968768031000066532 . PMID 12745923 . S2CID 218895820 . Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature . 391 (6666): 510–3. doi :10.1038/35185 . PMID 9461222 . S2CID 4406161 . Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature . 396 (6708): 279–82. doi :10.1038/24409 . PMID 9834036 . S2CID 4424498 . Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Cross RL (2004). "Molecular motors: turning the ATP motor" . Nature . 427 (6973): 407–8. doi :10.1038/427407b PMID 14749816 . S2CID 52819856 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
