AZ12216052

AZ12216052
AZ12216052
AZ12216052 structure.png
식별자
  • 2-[(4-브로모페닐)메틸술파닐]-N-(4-부탄-2-일페닐)아세트아미드
CAS 번호
PubChem CID
켐스파이더
화학 및 물리 데이터
공식C19H22브르NOS
몰 질량392.36 g/g−1/g/g
3D 모델(JSmol)
  • CCC(C)C1=CC=C(C=C1)NC(=O)CSCC2=CC=C(C=C2)Br
  • InChI=1S/C19H22BrNOS/c1-3-14(2)16-6-10-18(11-7-16)21-19(22)13-23-12-15-4-8-17(20)9-5-15/11,14H,3-13H(2)
  • 키: QKUYZJOTWYRWNF-UHFFFAOYSA-N

AZ-1216052는 메타로트로픽 글루탐산 수용체 8의 강력하고 선택적인 양성 알로스테릭 조절제로서 작용하며, 불안 [1][2][3][4][5]및 신경통증을 포함한 다양한 과정에서 이 수용체 아형의 역할에 대한 연구에 사용된다.

레퍼런스

  1. ^ Duvoisin RM, Pfankuch T, Wilson JM, Grabell J, Chhajlani V, Brown DG, et al. (October 2010). "Acute pharmacological modulation of mGluR8 reduces measures of anxiety". Behavioural Brain Research. 212 (2): 168–173. doi:10.1016/j.bbr.2010.04.006. PMC 2892883. PMID 20385173.
  2. ^ Reed BT, Morgans CW, Duvoisin RM (April 2013). "Differential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compounds". Neuropharmacology. 67: 88–94. doi:10.1016/j.neuropharm.2012.09.023. PMC 3562428. PMID 23164615.
  3. ^ Rossi F, Marabese I, De Chiaro M, Boccella S, Luongo L, Guida F, et al. (June 2014). "Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions". Journal of Neurophysiology. 111 (11): 2196–2209. doi:10.1152/jn.00212.2013. PMID 24304862.
  4. ^ Jantas D, Greda A, Leskiewicz M, Grygier B, Pilc A, Lason W (September 2015). "Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation". Neurochemistry International. 88: 124–137. doi:10.1016/j.neuint.2014.12.011. PMID 25661514. S2CID 8865211.
  5. ^ Jantas D, Grygier B, Zatorska J, Lasoń W (October 2018). "Allosteric and Orthosteric Activators of mGluR8 Differentially Affect the Chemotherapeutic-Induced Human Neuroblastoma SH-SY5Y Cell Damage: The Impact of Cell Differentiation State". Basic & Clinical Pharmacology & Toxicology. 123 (4): 443–451. doi:10.1111/bcpt.13041. PMID 29753314. S2CID 21666589.
Stub icon

신경계에 관한 이 약물 기사는 엉터리이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.