보칭거 콤플렉스

Botzinger complex

포유류에서 Bötzinger 콤플렉스(BötC)는 복측측두엽(rostraal vental medulla)과 복측호흡기둥에 위치한 신경세포의 그룹이다. 중수에서 이 그룹은 안면핵과 복측핵에서 모호한 곳에 위치한다.[1][2]

함수

뵈징거 콤플렉스는 호흡을[3][4] 조절하고 저산소증에 대응하는 데 중요한 역할을 한다.[5][6] Bözinger 콤플렉스는 주로 호흡기 활동을 억제하는 글리시네르그 뉴런으로[7] 구성되어 있다. 호흡 주기 단계 중 BötC는 흡기 후(Post-I) 활동을 생성하고 호기 후(Aug-e) 활동을 증가시킨다.[8][9][10]

이름

뵈칭거 콤플렉스는 1978년 독일 허쉬혼에서 열린 과학 모임에서 보칭거라는 이름의 백포도주 한 병이 그의 테이블에 놓여 있다는 것을 따서 UCLA 교수 잭 펠드먼이 이름을 지었다.[11]

연결

Bözinger 콤플렉스는

오직 독점적으로 글리시네르그인 BötC의 호기성 뉴런을 증강시키는 것만이 골수핵에 투영된다.[21][14]

Bözinger 단지에 대한 투영에는 핵 트랙투스 솔리타리(NTS)[22][23] DRG와 VRG가 포함된다.[24]

생리학

이 뉴런들은 본질적인 심장 박동조절기 입니다.[25] 포스트 I 뉴런은 초기 활동 폭발과 영감의 끝에서 활동 감소를 보여준다. 아우그-E 뉴런은 E2상 동안 발화를 시작하여 골수신경이 터지기 전에 끝난다.[19][26]

참조

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  2. ^ a b Otake K, Sasaki H, Mannen H, Ezure K (1987). "Morphology of expiratory neurons of the Bötzinger complex: an HRP study in the cat". J Comp Neurol. 258 (4): 565–79. doi:10.1002/cne.902580407. PMID 3034989.
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  6. ^ Nitsos I, Walker DW (1999). "The distribution of FOS-immunoreactive neurons in the brainstem, midbrain and diencephalon of fetal sheep in response to acute hypoxia in mid and late gestation". Brain Res Dev Brain Res. 114 (1): 9–26. doi:10.1016/s0165-3806(99)00010-3. PMID 10209238.
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  14. ^ a b Tian GF, Peever JH, Duffin J (1998). "Bötzinger-complex expiratory neurons monosynaptically inhibit phrenic motoneurons in the decerebrate rat". Exp Brain Res. 122 (2): 149–56. doi:10.1007/s002210050502. PMID 9776513.
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  16. ^ Bryant TH, Yoshida S, de Castro D, Lipski J (1993). "Expiratory neurons of the Bötzinger Complex in the rat: a morphological study following intracellular labeling with biocytin". J Comp Neurol. 335 (2): 267–82. doi:10.1002/cne.903350210. PMID 8227518.
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  19. ^ a b Smith JC, Abdala AP, Koizumi H, Rybak IA, Paton JF (2007). "Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms". J Neurophysiol. 98 (6): 3370–87. doi:10.1152/jn.00985.2007. PMC 2225347. PMID 17913982.
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  21. ^ Schreihofer AM, Stornetta RL, Guyenet PG (1999). "Evidence for glycinergic respiratory neurons: Bötzinger neurons express mRNA for glycinergic transporter 2". J Comp Neurol. 407 (4): 583–97. doi:10.1002/(sici)1096-9861(19990517)407:4<583::aid-cne8>3.0.co;2-e. PMID 10235646.
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