HSPH1

HSPH1
식별자
에일리어스	HSPH1, HSP105, HSP105A, HSP105B, NY-CO-25, 히트쇼크 단백질 패밀리 H(Hsp110) 멤버 1
외부 ID	OMIM: 610703 MGI: 105053 HomoloGene: 21322 GenCard: HSPH1
유전자 위치(인간)
크르.	13번 염색체(인간)
끝.	31,188 bp
유전자 위치(마우스)
크르.	5번 염색체(쥐)
끝.	149,559,841 bp
RNA발현패턴
	상단 표시 위치:
	기관지 상피 세포; ; 핵액컴벤스; ; 후중심회; ; 미산핵; ; 브로드만 23구역; ; 창호; ; 해마의 고유 영역 I; ; 브로드만 9구역; ; 상전두회; ; 중측두회;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	뉴클레오티드 결합; α-튜브린 결합; GO:0001948 단백질 결합; ATP 결합; 아데닐화합물교환인자활성;
셀룰러 컴포넌트	세포질; 세포; 세포내 소포 내강; 핵소체; 세포외 영역; 미소관; 세포외 엑소좀; 핵; 단백질 함유 복합체;
생물학적 과정	미토콘드리아에 대한 단백질 위치 결정의 음성 조절; 단백질티로신인산화효소활성양성조절; p38의 음성 조절MAPK 캐스케이드; 아포토시스 시그널링 경로의 음성 조절; 수용체유도세포증; 샤페론 보조인자 의존성 단백질 리폴드; NKT세포활성화양성조절; 전개 단백질에 대한 반응; 열에 대한 세포 반응 조절; 과산화수소에 대한 내인성 아포토시스 시그널링 경로의 음성 조절; MHC 클래스 I 생합성 과정의 양성 조절; RNA중합효소II에 의한 전사의 양성 조절; GO:0048552 촉매 활성 조절;
	출처:아미고 / QuickGO
맞춤법
	10808
	15505
	ENSG00000120694
	ENSMUSG000029657
	Q92598
	Q61699
	NM_001286503; NM_001286504; NM_001286505; NM_006644; NM_001349704
	NM_013559; NM_001347534
	NP_001273432; NP_001273433; NP_001273434; NP_006635; NP_001336633
	NP_001334463; NP_038587
	위키데이터
인간 보기/편집	마우스 표시/편집

히트쇼크 단백질 105kDa는 인체에서 HSPH1 ^[5]^[6]^[7]유전자에 의해 암호화되는 단백질이다.

상호 작용

HSPH1은 Cofilin ^[8]1과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000120694 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000029657 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (Jun 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
^ Ishihara K, Yasuda K, Hatayama T (Mar 1999). "Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105". Biochim Biophys Acta. 1444 (1): 138–42. doi:10.1016/s0167-4781(98)00254-1. PMID 9931472.
^ "Entrez Gene: HSPH1 heat shock 105kDa/110kDa protein 1".
^ Saito, Youhei; Doi Kazuya; Yamagishi Nobuyuki; Ishihara Keiichi; Hatayama Takumi (Feb 2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. ISSN 0006-291X. PMID 14733918.

추가 정보

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Hatayama T, Yasuda K, Yasuda K (1998). "Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells". Biochem. Biophys. Res. Commun. 248 (2): 395–401. doi:10.1006/bbrc.1998.8979. PMID 9675148.
Ishihara K, Yasuda K, Hatayama T (2000). "Phosphorylation of the 105-kDa heat shock proteins, HSP105alpha and HSP105beta, by casein kinase II". Biochem. Biophys. Res. Commun. 270 (3): 927–31. doi:10.1006/bbrc.2000.2541. PMID 10772927.
Hylander BL, Chen X, Graf PC, Subjeck JR (2000). "The distribution and localization of hsp110 in brain". Brain Res. 869 (1–2): 49–55. doi:10.1016/S0006-8993(00)02346-5. PMID 10865058. S2CID 7179171.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ishihara K, Yamagishi N, Hatayama T (2003). "Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function". Biochem. J. 371 (Pt 3): 917–25. doi:10.1042/BJ20021331. PMC 1223342. PMID 12558502.
Saito Y, Yamagishi N, Ishihara K, Hatayama T (2003). "Identification of alpha-tubulin as an hsp105alpha-binding protein by the yeast two-hybrid system". Exp. Cell Res. 286 (2): 233–40. doi:10.1016/S0014-4827(03)00054-5. PMID 12749852.
Chen WF, Huang MH, Tzang CH, et al. (2003). "Inhibitory actions of genistein in human breast cancer (MCF-7) cells". Biochim. Biophys. Acta. 1638 (2): 187–96. doi:10.1016/s0925-4439(03)00082-6. PMID 12853125.
Kai M, Nakatsura T, Egami H, et al. (2004). "Heat shock protein 105 is overexpressed in a variety of human tumors". Oncol. Rep. 10 (6): 1777–82. doi:10.3892/or.10.6.1777. PMID 14534695.
Piechotta K, Garbarini N, England R, Delpire E (2004). "Characterization of the interaction of the stress kinase SPAK with the Na⁺-K⁺-2Cl⁻ cotransporter in the nervous system: evidence for a scaffolding role of the kinase". J. Biol. Chem. 278 (52): 52848–56. doi:10.1074/jbc.M309436200. PMID 14563843.
Saito Y, Doi K, Yamagishi N, et al. (2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID 14733918.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Miyazaki M, Nakatsura T, Yokomine K, et al. (2005). "DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells". Cancer Sci. 96 (10): 695–705. doi:10.1111/j.1349-7006.2005.00093.x. PMID 16232202. S2CID 23598038.

인간 염색체 13번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000120694 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000029657 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9610721-5] Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (Jun 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.

[pmid9931472-6] Ishihara K, Yasuda K, Hatayama T (Mar 1999). "Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105". Biochim Biophys Acta. 1444 (1): 138–42. doi:10.1016/s0167-4781(98)00254-1. PMID 9931472.

[entrez-7] "Entrez Gene: HSPH1 heat shock 105kDa/110kDa protein 1".

[pmid14733918-8] Saito, Youhei; Doi Kazuya; Yamagishi Nobuyuki; Ishihara Keiichi; Hatayama Takumi (Feb 2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. ISSN 0006-291X. PMID 14733918.

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HSPH1

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레퍼런스

추가 정보