IMK1

IMK1
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	3S95, 5L6W, 5HVK, 5HVJ
식별자
별칭	LIMK1, LIMK, LIMK-1, LIM 도메인 키나제 1
외부 ID	OMIM: 601329 MGI: 104572 HomoloGene: 1738 GeneCard: LIMK1
유전자 위치(인간)
쳇.	7번 염색체(인간)
끝	74,195,525 bp
유전자 위치(마우스)
쳇.	5번 염색체(쥐)
끝	134,717,452 bp
RNA 표현 패턴
	표현된 상단
	자궁내막 세포; ; 꼬리에 꼬리를 물다; ; 전두엽 피질; ; 편도체; ; 브로드만 9구역; ; 강리온의 명성; ; 단모세포; ; 시상하부; ; 핵이 응축; ; 자궁경관;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	전이효소 활동; 뉴클레오티드 결합; 열충격 단백질 결합; 금속 이온 결합; 키나제 활동; GO:0001948 단백질 결합; 단백질 이질화 활동; ATP 바인딩; 단백질 키나아제 활성; 단백질 세린/스레오닌 키나아제 활성; 신호 변환기 활동;
셀룰러 컴포넌트	막으로 막다; 초점 접착; 세포질; 핵의; 골지 기구; 시토솔; 핵 반점; 뉴런 투영법; 라멜리포듐; 세포 투영;
생물학적 과정	혈소판 감염에 관련된 fc-감마 수용체 신호 경로; 인산화; 신경계 발달; 유비퀴틴-유니버시티 전이효소 활동에 대한 부정적 규제; Rho 단백질 신호 전달; 액틴 필라멘트 번들 어셈블리의 양성 규제; 사이토스켈레톤 조직으로 활동; 신호 전달; 액손 확장에 대한 긍정적인 규제; 단백질 인산화; 응력 섬유 조립체의 양성 조절;
	출처:아미고 / 퀵고
직교체
	3984
	16885
	ENSG00000106683
	ENSMUSG00000029674
	P53667
	P53668
	NM_016735; NM_001204426; NM_002314
	NM_010717; NM_001305875
	NP_001191355; NP_002305
	NP_001292804; NP_034847
	위키다타
인간 보기/편집	마우스 보기/편집

LIM domain kinase 1은 인간에서 LIMK1 유전자에 의해 암호화된 효소다.^[5]^[6]

함수

약 40개의 알려진 진핵종 LIM 단백질이 있는데, 이 단백질이 포함하는 LIM 도메인의 이름을 따서 이름이 지어졌다.LIM 도메인은 아연 손가락 2개를 포함하는 보존성이 높은 사이스테인이 풍부한 구조물이다.아연 손가락은 대개 DNA나 RNA에 결합하여 기능하지만, LIM 모티브는 단백질과 단백질의 상호작용을 매개할 것이다.LIM kinase-1과 LIM kinase-2는 2개의 N-terminal LIM 모티브와 중앙 PDZ 도메인, C-terminal 단백질 kinase 도메인의 독특한 조합을 가진 작은 서브 패밀리에 속한다.LIMK1은 세포내 신호 경로의 구성요소일 가능성이 높고 뇌 발달에 관여할 수 있다.^[7]

임상적 유의성

LIMK1 혈전도는 윌리엄스 신드롬의 시각공간적 건설적 인식 장애에 관련되어 있다.^[7]

상호작용

LIMK1은 다음과 상호 작용하는 것으로 나타났다.

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000106683 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000029674 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tassabehji M, Metcalfe K, Fergusson WD, Carette MJ, Dore JK, Donnai D, Read AP, Pröschel C, Gutowski NJ, Mao X, Sheer D (Aug 1996). "LIM-kinase deleted in Williams syndrome". Nat. Genet. 13 (3): 272–3. doi:10.1038/ng0796-272. PMID 8673124. S2CID 138698.
^ Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC (Jan 1997). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients". Genomics. 36 (2): 328–36. doi:10.1006/geno.1996.0469. PMID 8812460.
^ ^a ^b "Entrez Gene: LIMK1 LIM domain kinase 1".
^ Foletta VC, Lim MA, Soosairajah J, Kelly AP, Stanley EG, Shannon M, He W, Das S, Massague J, Bernard O, Soosairaiah J (September 2003). "Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1". J. Cell Biol. 162 (6): 1089–98. doi:10.1083/jcb.200212060. PMC 2172847. PMID 12963706.
^ Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (August 1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase". Science. 285 (5429): 895–8. doi:10.1126/science.285.5429.895. PMID 10436159.
^ Yokoo T, Toyoshima H, Miura M, Wang Y, Iida KT, Suzuki H, Sone H, Shimano H, Gotoda T, Nishimori S, Tanaka K, Yamada N (December 2003). "p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus". J. Biol. Chem. 278 (52): 52919–23. doi:10.1074/jbc.M309334200. PMID 14530263.
^ Wang JY, Frenzel KE, Wen D, Falls DL (August 1998). "Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition". J. Biol. Chem. 273 (32): 20525–34. doi:10.1074/jbc.273.32.20525. PMID 9685409.
^ Edwards DC, Sanders LC, Bokoch GM, Gill GN (September 1999). "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics". Nat. Cell Biol. 1 (5): 253–9. doi:10.1038/12963. PMID 10559936. S2CID 25250183.
^ Dan C, Kelly A, Bernard O, Minden A (August 2001). "Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin". J. Biol. Chem. 276 (34): 32115–21. doi:10.1074/jbc.M100871200. PMID 11413130.
^ Birkenfeld J, Betz H, Roth D (January 2003). "Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta". Biochem. J. 369 (Pt 1): 45–54. doi:10.1042/BJ20021152. PMC 1223062. PMID 12323073.

추가 읽기

Scott RW, Olson MF (2007). "LIM kinases: function, regulation and association with human disease". J. Mol. Med. 85 (6): 555–68. doi:10.1007/s00109-007-0165-6. PMID 17294230. S2CID 8881246.
Mizuno K, Okano I, Ohashi K, Nunoue K, Kuma K, Miyata T, Nakamura T (1994). "Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif". Oncogene. 9 (6): 1605–12. PMID 8183554.
Okano I, Hiraoka J, Otera H, Nunoue K, Ohashi K, Iwashita S, Hirai M, Mizuno K (1995). "Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs". J. Biol. Chem. 270 (52): 31321–30. doi:10.1074/jbc.270.52.31321. PMID 8537403.
Frangiskakis JM, Ewart AK, Morris CA, Mervis CB, Bertrand J, Robinson BF, Klein BP, Ensing GJ, Everett LA, Green ED, Pröschel C, Gutowski NJ, Noble M, Atkinson DL, Odelberg SJ, Keating MT (1996). "LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition". Cell. 86 (1): 59–69. doi:10.1016/S0092-8674(00)80077-X. PMID 8689688. S2CID 17786888.
Nebl G, Meuer SC, Samstag Y (1996). "Dephosphorylation of serine 3 regulates nuclear translocation of cofilin". J. Biol. Chem. 271 (42): 26276–80. doi:10.1074/jbc.271.42.26276. PMID 8824278.
Hiraoka J, Okano I, Higuchi O, Yang N, Mizuno K (1996). "Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domain". FEBS Lett. 399 (1–2): 117–21. doi:10.1016/S0014-5793(96)01303-8. PMID 8980133. S2CID 2815035.
Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (1998). "Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization". Nature. 393 (6687): 809–12. doi:10.1038/31735. PMID 9655398. S2CID 4326365.
Wang JY, Frenzel KE, Wen D, Falls DL (1998). "Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition". J. Biol. Chem. 273 (32): 20525–34. doi:10.1074/jbc.273.32.20525. PMID 9685409.
Edwards DC, Gill GN (1999). "Structural features of LIM kinase that control effects on the actin cytoskeleton". J. Biol. Chem. 274 (16): 11352–61. doi:10.1074/jbc.274.16.11352. PMID 10196227.
Sotiropoulos A, Gineitis D, Copeland J, Treisman R (1999). "Signal-regulated activation of serum response factor is mediated by changes in actin dynamics". Cell. 98 (2): 159–69. doi:10.1016/S0092-8674(00)81011-9. PMID 10428028. S2CID 15781260.
Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247. S2CID 22326394.
Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase". Science. 285 (5429): 895–8. doi:10.1126/science.285.5429.895. PMID 10436159.
Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999). "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics". Nat. Cell Biol. 1 (5): 253–9. doi:10.1038/12963. PMID 10559936. S2CID 25250183.
Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K (2000). "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop". J. Biol. Chem. 275 (5): 3577–82. doi:10.1074/jbc.275.5.3577. PMID 10652353.
Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, Koop BF (2000). "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23". Mamm. Genome. 11 (10): 890–8. doi:10.1007/s003350010166. PMID 11003705. S2CID 8575994.
Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001). "Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha". J. Biol. Chem. 276 (25): 23092–6. doi:10.1074/jbc.C100196200. PMID 11340065.
Dan C, Kelly A, Bernard O, Minden A (2001). "Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin". J. Biol. Chem. 276 (34): 32115–21. doi:10.1074/jbc.M100871200. PMID 11413130.
Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells". J. Biol. Chem. 276 (33): 31449–58. doi:10.1074/jbc.M102988200. PMID 11418599.

외부 링크

셀 마이그레이션 게이트웨이에 링크가 있는 LIMK1 정보

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000106683 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000029674 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8673124-5] Tassabehji M, Metcalfe K, Fergusson WD, Carette MJ, Dore JK, Donnai D, Read AP, Pröschel C, Gutowski NJ, Mao X, Sheer D (Aug 1996). "LIM-kinase deleted in Williams syndrome". Nat. Genet. 13 (3): 272–3. doi:10.1038/ng0796-272. PMID 8673124. S2CID 138698.

[pmid8812460-6] Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC (Jan 1997). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients". Genomics. 36 (2): 328–36. doi:10.1006/geno.1996.0469. PMID 8812460.

[entrez-7] "Entrez Gene: LIMK1 LIM domain kinase 1".

[pmid12963706-8] Foletta VC, Lim MA, Soosairajah J, Kelly AP, Stanley EG, Shannon M, He W, Das S, Massague J, Bernard O, Soosairaiah J (September 2003). "Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1". J. Cell Biol. 162 (6): 1089–98. doi:10.1083/jcb.200212060. PMC 2172847. PMID 12963706.

[pmid10436159-9] Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (August 1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase". Science. 285 (5429): 895–8. doi:10.1126/science.285.5429.895. PMID 10436159.

[pmid14530263-10] Yokoo T, Toyoshima H, Miura M, Wang Y, Iida KT, Suzuki H, Sone H, Shimano H, Gotoda T, Nishimori S, Tanaka K, Yamada N (December 2003). "p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus". J. Biol. Chem. 278 (52): 52919–23. doi:10.1074/jbc.M309334200. PMID 14530263.

[pmid9685409-11] Wang JY, Frenzel KE, Wen D, Falls DL (August 1998). "Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition". J. Biol. Chem. 273 (32): 20525–34. doi:10.1074/jbc.273.32.20525. PMID 9685409.

[pmid10559936-12] Edwards DC, Sanders LC, Bokoch GM, Gill GN (September 1999). "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics". Nat. Cell Biol. 1 (5): 253–9. doi:10.1038/12963. PMID 10559936. S2CID 25250183.

[pmid11413130-13] Dan C, Kelly A, Bernard O, Minden A (August 2001). "Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin". J. Biol. Chem. 276 (34): 32115–21. doi:10.1074/jbc.M100871200. PMID 11413130.

[pmid12323073-14] Birkenfeld J, Betz H, Roth D (January 2003). "Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta". Biochem. J. 369 (Pt 1): 45–54. doi:10.1042/BJ20021152. PMC 1223062. PMID 12323073.

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IMK1

네임스페이스

더

목차

함수

임상적 유의성

상호작용

참조

추가 읽기

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