분자생물학에서, mir-145 microRNA는 사람에게서 MIR145 유전자에 의해 암호화되는 짧은 RNA 분자이다. 마이크로 RNA는 여러 가지 [3]
대상 마이크로RNA는 다양한 표적 유전자의 하향 조절에 관여한다. 괴테 등mir-145의 실험적 과잉발현이 결합세포 접착분자 JAM-A와 유방암 과 자궁내막증 세포 에서 파신 단백질의 액틴 결합을 억제하여 세포의 [4] [5] 운동성 을 감소시킨다는 것을 보여주었다. Larsson [6] 외 연구진은 miR-145가 FLI1 유전자의 3' UTR을 목표로 한다는 것을 보여주었고, 이 발견은 나중에 Zhang 외 [7] 연구진 에 의해 뒷받침되었다.
암에서의 역할 miR-145는 종양억제제 로 [8] 유방암 에서 [5] 대장암 과 급성 골수성 [11]
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외부 링크
miRNA 전구체 패밀리
1-100 101-200 201-300 301-400 401+ 다른.
