페리플라킨 은 인간에게 PPL 유전자 에 의해 암호화된 단백질 이다.[5] [6] [7]
이 유전자에 의해 인코딩된 단백질은 데스모솜과 각질세포에 있는 표피 옥수수 봉투의 성분이다. 이 단백질의 N단자 영역은 혈장막과 상호작용을 하고 그 C단자 영역은 중간 필라멘트와 상호작용을 한다. 이 단백질은 막대영역을 통해 엔보플라킨과 콤플렉스를 형성한다. 이 단백질은 중간 필라멘트뿐만 아니라 옥수수 봉투와 데스모솜 사이의 연결고리 역할을 할 수 있다. 다양한 세포 성장과 생존 신호 과정을 매개하는 단백질 키나아제인 AKT1/PKB가 이 단백질과 상호작용하는 것으로 보고되어 AKT1 매개 신호에서 이 단백질의 국산화 신호로서 가능한 역할을 제안하고 있다.[7]
상호작용 PPL(gene)은 케라틴 8 [8] Envoplakin 과 상호작용 하는 것으로 나타났다.[9] [10]
참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000118898 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000039457 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ruhrberg C, Williamson JA, Maatta A, Watt FM (Jun 1998). "The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse". Genomics . 49 (1): 157–9. doi :10.1006/geno.1997.5206 . PMID 9570964 . ^ Aho S, McLean WH, Li K, Uitto J (Jun 1998). "cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes". Genomics . 48 (2): 242–7. doi :10.1006/geno.1997.5188 . PMID 9521878 . ^ a b "Entrez Gene: PPL periplakin" .^ Kazerounian, Shideh; Uitto Jouni; Aho Sirpa (Oct 2002). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol . Denmark. 11 (5): 428–38. doi :10.1034/j.1600-0625.2002.110506.x . ISSN 0906-6705 . PMID 12366696 . S2CID 25735126 . ^ Karashima, Tadashi; Watt Fiona M (Dec 2002). "Interaction of periplakin and envoplakin with intermediate filaments" . J. Cell Sci . England. 115 (Pt 24): 5027–37. doi :10.1242/jcs.00191 ISSN 0021-9533 . PMID 12432088 . ^ Ruhrberg, C; Hajibagheri M A; Parry D A; Watt F M (Dec 1997). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin" . J. Cell Biol . UNITED STATES. 139 (7): 1835–49. doi :10.1083/jcb.139.7.1835 . ISSN 0021-9525 . PMC 2132639 PMID 9412476 . 추가 읽기 Amagai M (1999). "Autoimmunity against desmosomal cadherins in pemphigus". J. Dermatol. Sci . 20 (2): 92–102. doi :10.1016/S0923-1811(99)00016-X . PMID 10379702 . Leung CL, Green KJ, Liem RK (2002). "Plakins: a family of versatile cytolinker proteins". Trends Cell Biol . 12 (1): 37–45. doi :10.1016/S0962-8924(01)02180-8 . PMID 11854008 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Ruhrberg C, Hajibagheri MA, Parry DA, Watt FM (1998). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin" . J. Cell Biol . 139 (7): 1835–49. doi :10.1083/jcb.139.7.1835 . PMC 2132639 PMID 9412476 . Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Res . 5 (1): 31–9. doi :10.1093/dnares/5.1.31 PMID 9628581 . Aho S, Rothenberger K, Tan EM, et al. (1999). "Human periplakin: genomic organization in a clonally unstable region of chromosome 16p with an abundance of repetitive sequence elements". Genomics . 56 (2): 160–8. doi :10.1006/geno.1998.5704 . PMID 10051401 . DiColandrea T, Karashima T, Määttä A, Watt FM (2000). "Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope" . J. Cell Biol . 151 (3): 573–86. doi :10.1083/jcb.151.3.573 . PMC 2185584 PMID 11062259 . van den Heuvel AP, de Vries-Smits AM, van Weeren PC, et al. (2003). "Binding of protein kinase B to the plakin family member periplakin" . J. Cell Sci . 115 (Pt 20): 3957–66. doi :10.1242/jcs.00069 PMID 12244133 . Kazerounian S, Uitto J, Aho S (2003). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol . 11 (5): 428–38. doi :10.1034/j.1600-0625.2002.110506.x . PMID 12366696 . S2CID 25735126 . Karashima T, Watt FM (2003). "Interaction of periplakin and envoplakin with intermediate filaments" . J. Cell Sci . 115 (Pt 24): 5027–37. doi :10.1242/jcs.00191 PMID 12432088 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Feng GJ, Kellett E, Scorer CA, et al. (2003). "Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation" . J. Biol. Chem . 278 (35): 33400–7. doi :10.1074/jbc.M305866200 PMID 12810704 . Kazerounian S, Aho S (2003). "Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope" . J. Biol. Chem . 278 (38): 36707–17. doi :10.1074/jbc.M303896200 PMID 12853457 . Straub BK, Boda J, Kuhn C, et al. (2004). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells" . J. Cell Sci . 116 (Pt 24): 4985–95. doi :10.1242/jcs.00815 PMID 14625392 . Kalinin AE, Idler WW, Marekov LN, et al. (2004). "Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia" . J. Biol. Chem . 279 (21): 22773–80. doi :10.1074/jbc.M313660200 PMID 15033990 . Beekman JM, Bakema JE, van de Winkel JG, Leusen JH (2004). "Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity" . Proc. Natl. Acad. Sci. U.S.A . 101 (28): 10392–7. Bibcode :2004PNAS..10110392B . doi :10.1073/pnas.0401217101 PMC 478582 PMID 15229321 .
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