ST7

ST7
식별자
에일리어스	ST7, ETS7q, FAM4A, FAM4A1, HELG, RAY1, SEN4, TSG7, 종양 발생 억제 7
외부 ID	OMIM: 600833 MGI: 1927450 HomoloGene: 10185 GeneCard: ST7
유전자 위치(인간)
크르.	7번 염색체(인간)
끝.	117,230,120 bp
유전자 위치(마우스)
크르.	6번 염색체(쥐)
끝.	17,943,024 bp
RNA발현패턴
	상단 표시 위치:
	신경절 융기; ; 소뇌 반구; ; 췌장체; ; 슬와 동맥; ; 우관상 동맥; ; 오른쪽 폐; ; 랑게르한스 섬; ; 상행 대동맥; ; 간우엽; ; 갑상선 좌엽;
	추가 참조 표현식 데이터
	없음
맞춤법
	7982
	64213
	ENSG00000004866
	ENSMUSG000029534
	문제 9NRC1
	Q99M96
	NM_021908; NM_018412
NM_001083315; NM_001289624; NM_001289625; NM_001289626; NM_001289627;
	NM_001289629; NM_022332
NP_060882; NP_068708; NP_001356527; NP_001356528; NP_001356529;
	NP_001356530; NP_001356531; NP_001356532; NP_001356533; NP_001356535; NP_001356536
NP_001076784; NP_001276553; NP_001276554; NP_001276555; NP_001276556;
	NP_001276558; NP_071727
	위키데이터
인간 보기/편집	마우스 표시/편집

종양원성 단백질 억제제 7은 ST7 ^[5]^[6]^[7]유전자에 의해 인체 내에서 부호화되는 단백질이다.ST7 정형어는^[8] 완전한 게놈 데이터를 이용할 수 있는 모든 포유동물에서 확인되었다.

기능.

이 제품의 유전자는 인간 염색체 7의 자폐증 의심 궤적으로 식별되는 영역에 매핑됩니다.자폐증 개인의 전체 코딩 영역에 대한 돌연변이 검사는 표현형 특이적 변이를 식별하지 못했으며, 이는 이 유전자에 대한 코딩 돌연변이가 자폐증의 병인에 관여할 가능성이 낮다는 것을 시사한다.이 유전자 생성물의 기능은 아직 밝혀지지 않았다.이 단백질의 다른 동질 형태를 코드하는 전사 변이가 ^[7]설명되었다.

상호 작용

ST7은 ITGB1BP3^[9] 및 GNB2L1과 ^[9]상호 작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000004866 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000029534 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M (October 1993). "Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1". Molecular and Cellular Biology. 13 (10): 6036–43. doi:10.1128/mcb.13.10.6036. PMC 364663. PMID 8105370.
^ Zenklusen JC, Rodriguez LV, LaCava M, Wang Z, Goldstein LS, Conti CJ (November 1996). "Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene". Genome Research. 6 (11): 1070–6. doi:10.1101/gr.6.11.1070. PMID 8938430.
^ ^a ^b "Entrez Gene: ST7 suppression of tumorigenicity 7".
^ "OrthoMaM phylogenetic marker: ST7 coding sequence".
^ ^a ^b Battle MA, Maher VM, McCormick JJ (June 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. 42 (24): 7270–82. doi:10.1021/bi034081y. PMID 12809483.

추가 정보

Zenklusen JC, Weitzel JN, Ball HG, Conti CJ (July 1995). "Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene". Oncogene. 11 (2): 359–63. PMID 7624150.
Zenklusen JC, Thompson JC, Troncoso P, Kagan J, Conti CJ (December 1994). "Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1". Cancer Research. 54 (24): 6370–3. PMID 7987830.
Zenklusen JC, Bièche I, Lidereau R, Conti CJ (December 1994). "(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 12155–8. Bibcode:1994PNAS...9112155Z. doi:10.1073/pnas.91.25.12155. PMC 45395. PMID 7991599.
Folstein SE, Mankoski RE (August 2000). "Chromosome 7q: where autism meets language disorder?". American Journal of Human Genetics. 67 (2): 278–81. doi:10.1086/303034. PMC 1287175. PMID 10889044.
Vincent JB, Herbrick JA, Gurling HM, Bolton PF, Roberts W, Scherer SW (August 2000). "Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual". American Journal of Human Genetics. 67 (2): 510–4. doi:10.1086/303005. PMC 1287197. PMID 10889047.
Zenklusen JC, Conti CJ, Green ED (April 2001). "Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31". Nature Genetics. 27 (4): 392–8. doi:10.1038/86891. PMID 11279520. S2CID 2749283.
Brown VL, Proby CM, Barnes DM, Kelsell DP (July 2002). "Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours". British Journal of Cancer. 87 (2): 208–11. doi:10.1038/sj.bjc.6600418. PMC 2376116. PMID 12107844.
Vincent JB, Petek E, Thevarkunnel S, Kolozsvari D, Cheung J, Patel M, Scherer SW (September 2002). "The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system". Genomics. 80 (3): 283–94. doi:10.1006/geno.2002.6835. PMID 12213198.
Dong SM, Sidransky D (September 2002). "Absence of ST7 gene alterations in human cancer". Clinical Cancer Research. 8 (9): 2939–41. PMID 12231539.
Wang S, Mori Y, Sato F, Yin J, Xu Y, Zou TT, Olaru A, Kimos MC, Perry K, Selaru FM, Deacu E, Sun M, Shi YC, Shibata D, Abraham JM, Greenwald BD, Meltzer SJ (January 2003). "An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma". Oncogene. 22 (3): 467–70. doi:10.1038/sj.onc.1206125. PMID 12545169.
Battle MA, Maher VM, McCormick JJ (June 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. 42 (24): 7270–82. doi:10.1021/bi034081y. PMID 12809483.
Sivasundaram K, Suzuki H, Seto M, Hosokawa Y (2004). "Mutational analysis of the ST7 gene in human myeloid tumor cell lines". Oncology Reports. 10 (6): 1737–9. doi:10.3892/or.10.6.1737. PMID 14534688.
Lu C, Xu HM, Ren Q, Ao Y, Wang ZN, Ao X, Jiang L, Luo Y, Zhang X (December 2003). "Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC". World Journal of Gastroenterology. 9 (12): 2662–5. doi:10.3748/wjg.v9.i12.2662. PMC 4612027. PMID 14669308.
Liu J, Gough J, Rost B (April 2006). "Distinguishing protein-coding from non-coding RNAs through support vector machines". PLOS Genetics. 2 (4): e29. doi:10.1371/journal.pgen.0020029. PMC 1449884. PMID 16683024.

인간 염색체 7번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000004866 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000029534 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8105370-5] Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M (October 1993). "Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1". Molecular and Cellular Biology. 13 (10): 6036–43. doi:10.1128/mcb.13.10.6036. PMC 364663. PMID 8105370.

[pmid8938430-6] Zenklusen JC, Rodriguez LV, LaCava M, Wang Z, Goldstein LS, Conti CJ (November 1996). "Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene". Genome Research. 6 (11): 1070–6. doi:10.1101/gr.6.11.1070. PMID 8938430.

[entrez-7] "Entrez Gene: ST7 suppression of tumorigenicity 7".

[OrthoMaM-8] "OrthoMaM phylogenetic marker: ST7 coding sequence".

[pmid12809483-9] Battle MA, Maher VM, McCormick JJ (June 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. 42 (24): 7270–82. doi:10.1021/bi034081y. PMID 12809483.

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ST7

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