S Wikipedije, slobodne enciklopedije
Apolipoprotein F Simbol APOF
Apolipoprotein F je protein koji je kod ljudi kodiran genom APOF .[ 5] [ 6]
Proizvod ovog gena jedan je od manjih apolipoproteina pronađenih u plazmi . Ovaj protein formira multiproteinska komplekse sa lipoproteinima i može biti uključen u transport i/ili esterifikaciju holesterola .[ 6]
Dužina polipeptidnog lanca je 326 aminokiselina , a molekulska težina 35.399 Da .[ 7]
10 20 30 40 50 MTGLCGYSAP DMRGLRLIMI PVELLLCYLL LHPVDATSYG KQTNVLMHFP LSLESQTPSS DPLSCQFLHP KSLPGFSHMA PLPKFLVSLA LRNALEEAGC QADVWALQLQ LYRQGGVNAT QVLIQHLRGL QKGRSTERNV SVEALASALQ LLAREQQSTG RVGRSLPTED CENEKEQAVH NVVQLLPGVG TFYNLGTALY YATQNCLGKA RERGRDGAID LGYDLLMTMA GMSGGPMGLA ISAALKPALR SGVQQLIQYY QDQKDANISQ PETTKEGLRA ISDVSDLEET TTLASFISEV VSSAPYWGWA IIKSYDLDPG AGSLEI
^ a b c GRCh38: Ensembl release 89: ENSG00000175336 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047631 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Day JR, Albers JJ, Gilbert TL, Whitmore TE, McConathy WJ, Wolfbauer G (Oct 1994). "Purification and molecular cloning of human apolipoprotein F". Biochem Biophys Res Commun . 203 (2): 1146–51. doi :10.1006/bbrc.1994.2302 . PMID 8093033 . ^ a b "Entrez Gene: APOF apolipoprotein F" .^ "UniProt, Q13790" . Pristupljeno 6. 8. 2021 .
Morton RE, Gnizak HM, Greene DJ, et al. (2008). "Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects" . J. Lipid Res . 49 (1): 127–35. doi :10.1194/jlr.M700258-JLR200 PMID 17901467 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Kabbara A, Payet N, Cottel D, et al. (2004). "Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population". Neurosci. Lett . 363 (2): 139–43. doi :10.1016/j.neulet.2004.03.066 . PMID 15172102 . S2CID 27752858 . Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources" . Mol. Cell. Proteomics . 3 (4): 311–26. doi :10.1074/mcp.M300127-MCP200 PMID 14718574 . Paromov VM, Morton RE (2003). "Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP)" . J. Biol. Chem . 278 (42): 40859–66. doi :10.1074/jbc.M306580200 PMID 12907677 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Wang X, Driscoll DM, Morton RE (1999). "Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F" . J. Biol. Chem . 274 (3): 1814–20. doi :10.1074/jbc.274.3.1814 PMID 9880564 . Koren E, McConathy WJ, Alaupovic P (1983). "Isolation and characterization of simple and complex lipoproteins containing apolipoprotein F from human plasma". Biochemistry . 21 (21): 5347–51. doi :10.1021/bi00264a035 . PMID 6816269 . Olofsson SO, McConathy WJ, Alaupovic P (1978). "Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma". Biochemistry . 17 (6): 1032–6. doi :10.1021/bi00599a014 . PMID 204339 .
