CHSY1
Hondroitin-sulfat sintaza 1 je enzim koji je kod ljudi kodiran genom CHSY1.[5][6]
CHSY1 kodira sintetezu hondroitin-sulfata, glikozaminoglikanske ekspresije na površini većine ćelija i u vanćelijskim matriksima. Glikozamoglikonski lanci kovalentno su povezani sa širokim spektrom jezgra porodice proteina i regulišu mnoge biološke procese, uključujući proliferaciju ćelija i prepoznavanje, taloženja vanćelijskog matriksa i morfogeneze.[6][7]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 802 aminokiseline, a molekulska težina 91 784 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAARGRRAWL | SVLLGLVLGF | VLASRLVLPR | ASELKRAGPR | RRASPEGCRS | ||||
| GQAAASQAGG | ARGDARGAQL | WPPGSDPDGG | PRDRNFLFVG | VMTAQKYLQT | ||||
| RAVAAYRTWS | KTIPGKVQFF | SSEGSDTSVP | IPVVPLRGVD | DSYPPQKKSF | ||||
| MMLKYMHDHY | LDKYEWFMRA | DDDVYIKGDR | LENFLRSLNS | SEPLFLGQTG | ||||
| LGTTEEMGKL | ALEPGENFCM | GGPGVIMSRE | VLRRMVPHIG | KCLREMYTTH | ||||
| EDVEVGRCVR | RFAGVQCVWS | YEMQQLFYEN | YEQNKKGYIR | DLHNSKIHQA | ||||
| ITLHPNKNPP | YQYRLHSYML | SRKISELRHR | TIQLHREIVL | MSKYSNTEIH | ||||
| KEDLQLGIPP | SFMRFQPRQR | EEILEWEFLT | GKYLYSAVDG | QPPRRGMDSA | ||||
| QREALDDIVM | QVMEMINANA | KTRGRIIDFK | EIQYGYRRVN | PMYGAEYILD | ||||
| LLLLYKKHKG | KKMTVPVRRH | AYLQQTFSKI | QFVEHEELDA | QELAKRINQE | ||||
| SGSLSFLSNS | LKKLVPFQLP | GSKSEHKEPK | DKKINILIPL | SGRFDMFVRF | ||||
| MGNFEKTCLI | PNQNVKLVVL | LFNSDSNPDK | AKQVELMRDY | RIKYPKADMQ | ||||
| ILPVSGEFSR | ALALEVGSSQ | FNNESLLFFC | DVDLVFTTEF | LQRCRANTVL | ||||
| GQQIYFPIIF | SQYDPKIVYS | GKVPSDNHFA | FTQKTGFWRN | YGFGITCIYK | ||||
| GDLVRVGGFD | VSIQGWGLED | VDLFNKVVQA | GLKTFRSQEV | GVVHVHHPVF | ||||
| CDPNLDPKQY | KMCLGSKAST | YGSTQQLAEM | WLEKNDPSYS | KSSNNNGSVR | ||||
| TA |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000131873 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032640 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". J Biol Chem. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.
- ^ a b "Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1".
- ^ supplied by OMIM
- ^ "UniProt, Q86X52" (jezik: англ.). Pristupljeno 13. 7. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
[uredi | uredi izvor]- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Yada T, Sato T, Kaseyama H, et al. (2003). "Chondroitin sulfate synthase-3. Molecular cloning and characterization". J. Biol. Chem. 278 (41): 39711–25. doi:10.1074/jbc.M304421200. PMID 12907687.
- Kitagawa H, Izumikawa T, Uyama T, Sugahara K (2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J. Biol. Chem. 278 (26): 23666–71. doi:10.1074/jbc.M302493200. PMID 12716890.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
Vanjski linkovi
[uredi | uredi izvor]- Lokacija ljudskog genoma CHSY1 i stranica sa detaljima o genu CHSY1 u UCSC Genome Browseru.