PRB4

PRB4
Identifikatori
Aliasi	PRB4
Vanjski ID-jevi	OMIM: 180990 GeneCards: PRB4
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek) Bend 12p13.2 Početak 11,307,077 bp Kraj 11,310,436 bp
Ontologija gena Molekularna funkcija • molekularna funkcija Ćelijska komponenta • extracellular region Biološki proces • GO:0022610 biološki proces Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	5545	n/a
Ensembl	ENSG00000274839 ENSG00000230657	n/a
UniProt	P10163	n/a
RefSeq (mRNK)	NM_002723 NM_001261399	n/a
RefSeq (bjelančevina)	n/a	n/a
Lokacija (UCSC)	Chr 12: 11.31 – 11.31 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Bazni pljuvačni prolinom bogati protein 4 je protein koji je kod ljudi kodiran genom PRB4.

Protein kodiran ovim genom spada upljuvačne proteine bogate prolinom. Ovaj i pet drugih gena koji također kodiraju pljuvačni proteine bogate prolinom (PRP), kao i gen koji kodira suznu žlijezdu PRP, čine PRP genski klaster u regiji 12p13 hromosoma 12.

PRB4 se posttranslacijski cijepa na tri različita zrela peptida:

• Protein N1
• Glikozilirani protein A
• Peptid P-D (poznat i kao Peptid IB-5 bogat prolinom)

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 310 aminokiselina, a molekulska težina 31 326 Da.

10		20		30		40		50
MLLILLSVAL		LALSSAESSS		EDVSQEESLF		LISGKPEGRR		PQGGNQPQRP
PPPPGKPQGP		PPQGGNQSQG		PPPPPGKPEG		RPPQGGNQSQ		GPPPHPGKPE
RPPPQGGNQS		QGPPPHPGKP		ESRPPQGGHQ		SQGPPPTPGK		PEGPPPQGGN
QSQGTPPPPG		KPEGRPPQGG		NQSQGPPPHP		GKPERPPPQG		GNQSHRPPPP
PGKPERPPPQ		GGNQSQGPPP		HPGKPEGPPP		QEGNKSRSAR		SPPGKPQGPP
QQEGNKPQGP		PPPGKPQGPP		PAGGNPQQPQ		APPAGKPQGP		PPPPQGGRPP
RPAQGQQPPQ

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

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• Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092. S2CID 31373141.
• Lyons KM, Stein JH, Smithies O (1989). "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics. 120 (1): 267–78. doi:10.1093/genetics/120.1.267. PMC 1203497. PMID 2851479.
• Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. doi:10.1016/S0021-9258(17)39156-1. PMID 2993301.
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• Warner TF, Azen EA (1984). "Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract". Am. Rev. Respir. Dis. 130 (1): 115–8. doi:10.1164/arrd.1984.130.1.115 (neaktivno 31. 5. 2021). PMID 6377992.CS1 održavanje: DOI nije aktivan od 2021 (link)
• Saitoh E, Isemura S, Sanada K (1983). "Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva". J. Biochem. 93 (2): 495–502. doi:10.1093/jb/93.3.883. PMID 6841349.
• Kauffman DL, Keller PJ, Bennick A, Blum M (1993). "Alignment of amino acid and DNA sequences of human proline-rich proteins". Crit. Rev. Oral Biol. Med. 4 (3–4): 287–92. doi:10.1177/10454411930040030501. PMID 8373986.
• Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. doi:10.1007/BF00364656. PMID 8422499. S2CID 24058984.
• Azen EA, Amberger E, Fisher S, et al. (1996). "PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins". Am. J. Hum. Genet. 58 (1): 143–53. PMC 1914931. PMID 8554050.
• Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell. 9 (3): 575–83. doi:10.1091/mbc.9.3.575. PMC 25286. PMID 9487127.
• Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi:10.1046/j.1432-1327.2001.02241.x. PMID 11422372.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vallat JM, Magy L, Lagrange E, et al. (2007). "Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance". Acta Neuropathol. 113 (4): 443–9. doi:10.1007/s00401-007-0196-7. PMID 17294201. S2CID 42561185.