SOSTDC1

SOSTDC1
Identifikatori
Aliasi	SOSTDC1
Vanjski ID-jevi	OMIM: 609675 MGI: 1913292 HomoloGene: 9154 GeneCards: SOSTDC1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	16,530,580 bp
Lokacija gena (miš)
Hrom.	Hromosom 12 (miš)
Kraj	36,368,451 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• BMP binding; • BMP receptor activity;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• pattern specification process; • odontogenesis of dentin-containing tooth; • hair follicle morphogenesis; • mammary gland bud morphogenesis; • negative regulation of cell fate commitment; • Wnt-signalni put; • negative regulation of canonical Wnt signaling pathway; • negative regulation of Wnt signaling pathway; • BMP signaling pathway; • negative regulation of BMP signaling pathway; • negative regulation of myoblast differentiation; • negative regulation of determination of dorsal identity;
	Izvori:Amigo / QuickGO
Ortolozi
	25928
	66042
	ENSG00000171243
	ENSMUSG00000036169
	Q6X4U4
	Q9CQN4
	NM_015464
	NM_025312
	NP_056279
	NP_079588
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Sklerostinski protein 1 sa domenom jest protein koji je kod ljudi kodiran genom SOSTDC1.^[5]

Aminokiselinska sekvenca

Ovaj gen je član porodice sklerostina i kodira N-glikozilirani, izlučeni protein sa C-terminal om, cistinom, domenom nalik čvoru. Ovaj protein funkcionira kao antagonist morfogenetskog proteina kosti (BMP). Konkretno, izravno se povezuje s BMP-om, sprečavaujući im da vežu svoje receptore, čime regulira signalizaciju BMP-a tokom ćelijske proliferacije, diferencijacije i pogramirane ćelijske smrti.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171243 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036169 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SOSTDC1 sclerostin domain containing 1".
^ "UniProt, Q6X4U4" (jezik: engleski). Pristupljeno 29. 9. 2021.

Yanagita M (juni 2005). "BMP antagonists: their roles in development and involvement in pathophysiology". Cytokine & Growth Factor Reviews. 16 (3): 309–17. doi:10.1016/j.cytogfr.2005.02.007. PMID 15951218.
Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N (decembar 2003). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". Developmental Biology. 264 (1): 91–105. doi:10.1016/j.ydbio.2003.08.011. PMID 14623234.
Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T (april 2004). "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney". Biochemical and Biophysical Research Communications. 316 (2): 490–500. doi:10.1016/j.bbrc.2004.02.075. PMID 15020244.
Goto M, Eddy EM (oktobar 2004). "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". The Journal of Biological Chemistry. 279 (40): 42128–38. doi:10.1074/jbc.M403190200. PMID 15280373.