S Wikipedije, slobodne enciklopedije
Sulfataza-modificirajući faktor 2 jest enzim koji je kod ljudi kodiran genom SUMF2 .[ 5] [ 6]
Dužina polipeptidnog lanca je 301 aminokiselina , а molekulska težina 33.843 Da .[ 7]
10 20 30 40 50 MARHGLPLLP LLSLLVGAWL KLGNGQATSM VQLQGGRFLM GTNSPDSRDG DGPVREATVK PFAIDIFPVT NKDFRDFVRE KKYRTEAEMF GWSFVFEDFV SDELRNKATQ PMKSVLWWLP VEKAFWRQPA GPGSGIRERL EHPVLHVSWN DARAYCAWRG KRLPTEEEWE FAARGGLKGQ VYPWGNWFQP NRTNLWQGKF PKGDKAEDGF HGVSPVNAFP AQNNYGLYDL LGNVWEWTAS PYQAAEQDMR VLRGASWIDT ADGSANHRAR VTTRMGNTPD SASDNLGFRC AADAGRPPGE L
Katalizna mjesta sulfataza su aktivna samo ako sadrže jedinstvenu aminokiselinu , C-alfa-formilglicin (FGly). Ostatak FGly posttranslacijski se generira iz cisteina , enzimima s aktivnošću stvaranja FGly. Gen opisan u ovom zapisu je član porodice faktora koji modifikuju sulfataza i kodira protein sa domenom DUF323 koja se nalazi u lumenu endoplazmatskog retikuluma . Ovaj protein ima niske nivoe aktivnosti generiranja FGly, ali se može heterodimerizirati s drugim članom porodice – proteinom s visokim nivoom aktivnosti stvaranja FGly. Okarakterizirane su alternativno prerađene varijante transkripta , koje kodiraju različite izoforme .[ 6]
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