SYPL1

SYPL1
Identifikatori
Aliasi	SYPL1
Vanjski ID-jevi	OMIM: 616665 MGI: 108081 HomoloGene: 4915 GeneCards: SYPL1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	106,112,576 bp
Lokacija gena (miš)
Hrom.	Hromosom 12 (miš)
Kraj	33,029,859 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• transporter activity; • syntaxin-1 binding;
Ćelijska komponenta	• Sinapsna vezikula; • secretory granule; • cytoplasmic vesicle membrane; • membrana; • Melanosom; • GO:0016023 citoplazmatska vezikula; • integral component of synaptic vesicle membrane; • integral component of membrane; • integral component of plasma membrane; • Egzosom; • synaptic vesicle membrane;
Biološki proces	• chemical synaptic transmission; • GO:0015915 transport;
	Izvori:Amigo / QuickGO
Ortolozi
	6856
	19027
	ENSG00000008282
	ENSMUSG00000020570
	Q16563
	O09117
	NM_006754; NM_182715
	NM_013635; NM_198710
NP_006745; NP_874384; NP_001368839; NP_001368840; NP_001368841;
	NP_001368842; NP_001368844; NP_001368845; NP_001368846; NP_001368847; NP_001368848; NP_001368849; NP_001368850
	NP_038663; NP_942003
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Sinaptofizinoliki protein 1 jest protein koji je kod ljudi kodiran genom SYPL1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 259 aminokiselina, а molekulska težina 28.565 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAPNIYLVRQ	RISRLGQRMS	GFQINLNPLK	EPLGFIKVLE	WIASIFAFAT
CGGFKGQTEI	QVNCPPAVTE	NKTVTATFGY	PFRLNEASFQ	PPPGVNICDV
NWKDYVLIGD	YSSSAQFYVT	FAVFVFLYCI	AALLLYVGYT	SLYLDSRKLP
MIDFVVTLVA	TFLWLVSTSA	WAKALTDIKI	ATGHNIIDEL	PPCKKKAVLC
YFGSVTSMGS	LNVSVIFGFL	NMILWGGNAW	FVYKETSLHS	PSNTSAPHSQ
GGIPPPTGI

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000008282 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020570 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SYPL1 synaptophysin-like 1".
^ "UniProt, Q16563" (jezik: engleski). Pristupljeno 29. 9. 2021.

Dopunska literatura

Zhong CZ, Hayzer DJ, Runge MS (1992). "Molecular cloning of a cDNA encoding a novel protein related to the neuronal vesicle protein synaptophysin". Biochim. Biophys. Acta. 1129 (2): 235–8. doi:10.1016/0167-4781(92)90495-l. PMID 1730063.
Leube RE (1994). "Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human". Differentiation. 56 (3): 163–71. doi:10.1046/j.1432-0436.1994.5630163.x. PMID 8034131.
Haass NK, Kartenbeck MA, Leube RE (1996). "Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles". J. Cell Biol. 134 (3): 731–46. doi:10.1083/jcb.134.3.731. PMC 2120938. PMID 8707851.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Windoffer R, Borchert-Stuhlträger M, Haass NK, et al. (1999). "Tissue expression of the vesicle protein pantophysin". Cell Tissue Res. 296 (3): 499–510. doi:10.1007/s004410051310. PMID 10370136. S2CID 6765747.
Brooks CC, Scherer PE, Cleveland K, et al. (2000). "Pantophysin is a phosphoprotein component of adipocyte transport vesicles and associates with GLUT4-containing vesicles". J. Biol. Chem. 275 (3): 2029–36. doi:10.1074/jbc.275.3.2029. PMID 10636906.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000008282 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020570 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SYPL1 synaptophysin-like 1".

[UniProt-6] "UniProt, Q16563" (jezik: engleski). Pristupljeno 29. 9. 2021.

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