Prescrição, Farmacologia e Fitoterapia Aplicada À Estética Unidade - IV - 01
Prescrição, Farmacologia e Fitoterapia Aplicada À Estética Unidade - IV - 01
Prescrição, Farmacologia e Fitoterapia Aplicada À Estética Unidade - IV - 01
E FITOTERAPIA APLICADA À
ESTÉTICA
UNIDADE IV
FITOCOSMÉTICOS
Elaboração
Juliana Tironi Machado
Produção
Equipe Técnica de Avaliação, Revisão Linguística e Editoração
SUMÁRIO
UNIDADE IV
FITOCOSMÉTICOS.......................................................................................................................................................................5
CAPÍTULO 1
FITODERMOCOSMÉTICOS ............................................................................................................................................. 5
REFERÊNCIAS.........................................................................................................................................16
FITOCOSMÉTICOS UNIDADE IV
Capítulo 1
FITODERMOCOSMÉTICOS
» Óleo de copaíba: tem uma forte demanda no mercado de Manaus, como remédio
natural com amplo espectro de uso. Tem sido experimentado pela indústria de
cosméticos, mas a baixa tecnologia de cultivo e extração, o deixa dependente do
puro extrativismo predatório, tornando seu preço muito elevado e sua qualidade
muito baixa, para sua utilização e comercialização em maior escala.
» Urucum: utilizado na indústria de alimento como corante natural, pode ser também
utilizado na indústria de cosméticos. Não tem sido estudado no Brasil para se
descrever a estrutura química de seus pigmentos.
» Andiroba: planta de uso medicinal, cujo óleo é utilizado em medicina caseira para
fricção de tecidos inflamados, como repelente e na indústria de cosméticos como
protetor solar.
5
UNIDADE iv | FITOCOSMÉTICOS
A seguir está uma relação de plantas utilizadas em fitocosmética, bem como seus efeitos
já reconhecidos em cosmética e seus compostos ativos.
6
FITOCOSMÉTICOS | UNIDADE iv
7
UNIDADE iv | FITOCOSMÉTICOS
Fontes: BAI et al., 2010; MENGONI et al., 2011; SUI et al., 2012; DRAELOS, 2001; CHOI; CHUNG, 2003;
KAPOR et al., 2009; WANG et al., 2008; GEDIYA et al., 2011; HEXSEL et al., 2005; ABURJAI; NATSHEH,
2003.
Um alerta! O uso de óleos essenciais por via oral é contraindicado e pode ser uma
conduta arriscada, pois não existem dados na literatura que garantam a segurança por
essa via de administração.
» Antibacteriano.
» Ele pode agir diminuindo dores de cabeça, isso acontece devido ao seu efeito
estimulante da circulação (age aumentando o fluxo sanguíneo para o cérebro).
8
FITOCOSMÉTICOS | UNIDADE iv
9
UNIDADE iv | FITOCOSMÉTICOS
10
FITOCOSMÉTICOS | UNIDADE iv
11
UNIDADE iv | FITOCOSMÉTICOS
» Utilização em estética: óleos e cremes para massagem, loções para pele oleosa.
12
FITOCOSMÉTICOS | UNIDADE iv
1.3.2. Xampus
» Conceito: solução ou suspensão, contendo um ou mais princípios ativos, para
aplicação na superfície do couro cabeludo.
1.3.3. Espuma
» Conceito: forma farmacêutica que consiste de um grande volume de gás disperso
em um líquido, geralmente contendo uma ou mais substâncias ativas. É formada
pela ação de um propelente, podendo, também, haver outros excipientes.
13
UNIDADE iv | FITOCOSMÉTICOS
1.3.4. Gel
» Conceito: forma farmacêutica semissólida com um ou mais princípios ativos, que
contém um agente gelificante para fornecer firmeza a uma solução ou dispersão
coloidal (um sistema no qual partículas de dimensão coloidal – tipicamente entre
1 nm e 1 mm – são distribuídas uniformemente através do líquido). Um gel pode
conter partículas suspensas.
1.3.5. Pomada
» Conceito: forma farmacêutica semissólida para aplicação na pele ou nas membranas
mucosas, que consiste de solução ou dispersão de um ou mais princípios ativos
em baixas proporções, em uma base adequada. Ex.: lenço umedecido.
14
PARA (NÃO) FINALIZAR
A atuação dos profissionais da área da saúde em estética exige desse uma dedicação
especial na busca de novos conhecimentos. Diariamente, novas pesquisas se iniciam e
novas descobertas surgem a respeito da influência dos fitoquímicos e fitoterápicos no
desenvolvimento e tratamento de desordens estéticas.
15
REFERÊNCIAS
ABIDOV, M.; RAMAZANOV, Z.; SEIFULLA, R.; GRACHEV, S. The effects of Xanthigen in the weight
management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver
fat. Diabetes Obes Metab; 12(1): 72-81, 2010.
ADEBAMOWO, C. A.; et al. Milk consumption and acne in adolescent girls. Dermatol Online J; 12(4):1, 2006.
ADEBAMOWO, et al. High school dietary intake and teenage acne. J. Am. Acad. Dermatol. 52(2): 207-
14, 2005.
AFAQ, F.; MUKHTAR H. Botanical antioxidants in the prevention of photocarcinogenesis and photoaging.
Exp Dermatol. 2006 Sep;15(9):678-84.
AKENDENGUÉ, B.; LOUIS, A. M. Medicinal plants used by the Masango people in Gabon. J Ethnopharmacol;
41(3):193-200, 1994.
ANDREW, G. Diseases on hair follicles leading to hair loss part 1: nonscarring alopecias. Skinmed 3(4),
pp.209-214, 2004.
ANDREY, Y. A. V. Sistemic fotoprotection with alfa tocopherol and beta carotene, skin dermiis effect.
Clinical and Experimental Dermatology, Cardiff, v. 27, pp.170-176, 2002.
ASLAM, M. N.; LANSKY, E. P.; VARANI, J. Pomegranate as a cosmeceutical source: pomegranate fractions
promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in
human skin cells. J Ethnopharmacol. 2006 Feb 20; 103(3):311-8,2005.
AZIMI, H.; FALLAH-TAFTI, M.; KHAKSHUR, A. A.; ABDOLLAHI, M. A review of phytotherapy o acne vulgaris:
perspective of new pharmacological treatments. Fitoterapia. 2012.
BABEL, W. et al. Oral administration of (14) C labeled gelatin hydrolysate leads to an accumulation of
radioactivity in cartilage of mice (CS7/BL). J Nutr; 129: 1891-5. 1999.
BARBOSA, K. B. F.; COSTA, N. M. B; ALFENAS, C. G. et al. Oxidative stress: concept, implications and
modulating factors. Rev Nutr; 23(4): 2010.
BARBUL, A. Proline Precursors to Sustain Mammalian Collage Synthesis. J Nutr; 138: 2021s-2024S; 2008.
BARRIOS, R. J; KHERADMAND, F.; BATTS, L.; CORRY, D. B. Asthma: pathology and pathophysiology.
ArchnPathol Lab Med; 2006 130(4):447-51.
BASU, R. J. A.; PEARSON, K. J.; PRICE, N. L. et al. Resveratrol improves health and survival of mice on a
highcalorie diet. Nature; 444: 337-342. 2006.
16
Referências
BASU, R.; BREDA, E.; OBERG, A. L. et al. Mechanisms of the age-associated deterioration in glucose
tolerance: contribution of alterations in insulin secretion, action, and clearance. Diabetes; 52: 1738-1748,
2003.
BERGINC. K.; ZAKELJ, S.; URSIC, D.; KRISTL, A. Aged garlic extract stimulates p-glycoprotein and multidrug
resistance associated protein 2 mediated effluxes. Biol Pharm Bull.; 32(4):694-9, 2009.
BERNATCHEZ, P. N.; SOKER, S.; SIROIS, M. G. Vascular endothelial growth factor effect on endothelial cell
proliferation, migration, and platelet-activating factor synthesis is Flk- 1-dependent. J Biol Chem; 274:
31047–31054. 1999.
BERRA, B.; RIZZO, A. M. Glycemic index, glycemic load, wellness and beauty: the state of art. Clin Dermatol;
2009; 27(2):230-5.
BERTELLI, A. A.; BACCALINI, R.; BATTAGLIA, E.; FALCHI, M.; FERRERO, M. E. Resveratrol inhibits TNF alpha-
induced endothelial cell activation. Therapie, 56: 613-616, 2001.
BIESALSKI, H. K.; JEVIC, O. C. UV light, Beta-carotene and Human Shin-Beneficial and Potentially Harmful
Effects. Archives of Biochemistry and Biophysics. Stuttgardt, v. 389, pp.1-6, 2001.
BRADLEY, P. R., ed. British Herbal Compendium, vol 1. Bournemouth: Brit-ish Herbal Medicine
Association, 1992.
BROWN-BORG, H. M. Hormonal regulation of longgevity and mammals. Ageing Res Rev; 6(1): 28-45, 2007.
BROWN-BORG, H. M.; RAKOCZY,S. G. Growth hormone administration to long-living dwart mice alters
multiple components Of the antioxidative defense system. Mech Ageing Dev; 124: 1013-1024. 2003.
CADENAS, E.; DAVIES, K. Mitochondrial free radical generation, oxidative stress, and aging. Free Radical
boil. Med; 29(4):222-30,2000.
CAILI, F.; HUAN, S.; QUANHONG, L. A review on pharmacological activities and utilization technologies
of pumpkin. Plant Foods Hum Nutr; 61(2):73-80, 2006.
CAMOUSE, M. M.; DOMINGO, D. S.; SWAIN, F. R.; CONRAD, E. P.; MATSUI, M. S.; MAES, D.; DECLERCQ, L.;
COOPER, K. D.; STEVENS, S. R.; BARON, E. D. Topical application of green and white tea extracts provides
protection from solar-simulated ultraviolet light in human skin. Exp Dermatol. jun;18(6):522-6, 2009.
CAMPISI, J. Senescent cells, tumor supression, and organismal aging: good citizens, bad neighbors. Cell;
120: 513-522, 2005.
CANI, P. D.; AMAR, J.; IGLESIAS, M. A. et al. Metabolic endotoxemia initiates obesity and insulin resistance.
Diabetes; 2007;56(7):1761-1772.
CAPOTE, R.; ALONSO-LEBRERO, J. L.; GARCÍA, F.; BRIEVA, A.; PIVEL, J. P.; GONZÁLEZ S. Polypodium
leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition. J Photochem
Photobiol B. Mar 1;82(3):173-9, 2006.
CARDOSO, C. R.; SOUZA, M. A.; FERRO, E. A. et al. Influence of topical of n-3 and n-6 essential and n-9
nonessencital faty acids on the heling of cutaneous wounds. Wound Rapair Regen, 12(2):235-43, 2004.
17
Referências
CASPERS, P. J.; LUCASSEN, G. W.; PUPPELS, G. J. Combined in vivo confocal Raman spectroscopy and
confocal microscopy of human skin. Biophys J., Jul;85(1):572-80, 2003.
CLARK, K. L.; SEBASTIANELLI, W.; FLECHSENHAR, K. R. et al. 24-Week study on the use collagen hydrolysate
as a dietary supplement in athletes with activity- related join pain. Curr Med Opin; 24; 1-12, 2008.
CORDAIN, L. Dietary implications for the development of acne: a shifting paradigm. In: U.S. Dermatology
Review II, (Ed. BEDLOW, J). London: Touch Briefings Publications, 2006.
CORDAIN, L. Implications for the role of diet in acne. Semin Cutan Med Surg; 24:84-91, 2005.
CORNWELL, T.; COHICK, W.; RASKIN, I.; Dietary phytoestrogens and health. Phytochem; 65: 995-1016, 2004.
CREELY, S. J.; MCTERNAN, P. G.; KUSMINSKI, C. M. et al. Lipopolysaccharide activates an innate immune
system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol
Metabol.;292(3):E740-747, 2007.
DANBY, W. Acne and milk, the diet myth, and beyond. J am acad dermatol; 52(2):360-2, 2005.
DENG, R.; CHOW, T. J. Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae Spirulina.
Cardiovasc Ther.; 28(4):e33-45, 2010.
DENG, W.; XI, D.; MAO, H. et al. The use of molecular techniques based on ribosomal RNA and DNA for
rumen microbial ecosystem studies: a review. Mol Biol Rep;35:265-274, 2008.
DREW, B.; PHANEUF, S.; DIRKS, A. et al. Effects of aging and caloric restriction on mitochondrial energy
production in gastrocnemius muscle and heart. Am J Physiol Regul Integr Comp Physiol; 284(2): 2003.
ELIAKIM, A.; BEYTH, Y. Exercise training, menstrual irregularities and bone development in children and
adolescents. J Pediatr Adolesc Gynecol; 16:201-6, 2003.
EMANUELE, E.; MINORETTI, P.; ALTABAS, K.; GAETA, E.; ALTABAS, V. Adiponectin expression in subcutaneous
adipose tissue is reduced in women with cellulite. Int J Dermatol; 50(4):412-6, 2011.
EMANUELE et. al. A multilocus candidate approach identifies ACE and HIF1A as susceptibiliy genes for
cellulite, JEADV, 24, 930-935, 2010.
ERNST, E.; PITTLER, M. H. Yohimbine for erectile dysfunction: a systematic review and meta-analysis of
randomized clinical trials. J Urol; 159(2): 433-6, 1998.
FALCHUK, K. H. The biochemical basis of zinc physiology. Physiol Rev, 73(1) 1993.
FISK, W. A.; LEV-TOV, H. A.; SIVAMANI, R. K. Botanical and phytochemical therapy of acne: a systematic
review. Phytother Res; 28(8):1137-52, 2014.
FITZPATRICK, T. B.; FREEDBERG, E. M. Fitzpatrick´s dermatology in general medicine. 5th ed. Mc Graw-
Hill, 1999.
18
Referências
OESSER, S.; ADAM, M.; FORSTER, M. J.;SOHAL, B. H.; SOHAL, R. S. Reversible effects of long-term caloric
restrition on protein oxidative damage. J Geronontol A Biol Sci Med Sci; 55: B522-B529, 2000.
FORSYTHE, L. K.; WALLACE, J. M. W.; LIVINGSTONE, M. B. E. Obesity and inflammation: the effects of
weight loss. Nutr Res Rev; 21: 117-133, 2008.
FRYE, E .B.; DEGENHARDT, T. P.; THORPE, S. R. et al. Role of the Maillard reaction in aging of tisuue proteins:
advanced glycatien end product-dependent increase in imidazolium cross-links in human lens proteins.
J Biol Chem; 273: 18714-18719, 2008.
FU, Y. T.; LEE, C. W.; KO, H. H.; YEN, F. L. Extracts of Artocarpus communis decrease α-melanocyte stimulating
hormone-induced melanogenesis through activation of ERK and JNK signaling pathways. Scientific World
Journal, 5;2014:724314, 2014.
FUKAO, H.; IJIRI, Y.; MIURA, M.; HASHIMOTO, M.; YAMASHITA, T.; FUKUNAGA, C.; OIWA, K.; KAWAI,
Y.; SUWAM YAMAMOTO, J. Effect of trans-resveratrol on the thrombogenicity and atherogenicity in
apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice. Department of Nutritional
Science, Faculty of Food Culture, Kurashiki Sakuyo University, 3515 Nagao, Tamashima, 710-0292. Blood
Coagul Fibrinolysis. 15(6):441-6, 2004.
FULCO, M.; SCHILTZ, R. L., IEZZI, S. et al. Sir2 regulates skeletal muscle differentiation as a potential sensor
of the redoz state. Mol Cell; 12: 51-62, 2003.
GEILEN, et al. Metabolic disorders involving the hair. In: CAMACHO et al. Hair and its disorders. UK:
Martin Dunitz, 2000.
GLAUERT, H. P. Vitamin E and NF-kappaB activation: a review. Vitam Horm; 76:135-53, 2007.
GODARD, M. P.; JOHNSON, B. A.; RICHMOND, S. R. Body composition and hormonal adaptations associated
with forskolin consumption in overweight and obese men. Obes Res; 13(8): 1335-43, 2005.
GODFREY, K. M.; BARKER, D. J. Fetal programming and adult health. Public Health Nutr; 4: 611 – 624, 2001.
GODOY, J. M. P.; GODOY, M. F. G. Celulite do diagnóstico ao Tratamento. São José do Rio Preto, 2003.
GOLLNICK, H. et al. Management of acne: a report from Global Alliance to Improve Outcomes in Acne. J
Am Acad Dermatol; 49(suppl):S1-37, 2003.
GOMBAU, L.; GARCÍA, F.; LAHOZ, A.; FABRE, M.; RODA-NAVARRO, P.; MAJANO, P.; ALONSO-LEBRERO,
J. L.; PIVEL, J. P.; CASTELL, J. V.; GÓMEZ-LECHON, M. J.; GONZÁLEZ, S. Polypodium leucotomos extract:
antioxidant activity and disposition. Toxicol In Vitro; 20(4):464-71, 2006.
GOMES, A. J.; LUNARDI, C. N.; GONZALEZ, S.; TEDESCO, A. C. The antioxidant action of Polypodium
leucotomos extract and kojic acid: reactions with reactive oxygen species. Braz J Med Biol Res,
34(11):1487-94, 2001.
19
Referências
GOPALAN, A.; REUBEN, S. C.; AHMED, S.; DARVESH, A. S.; HOHMANN, J.; BISHAYEE, A. The health benefits
of blackcurrants. Food Funct; 3:795-809, 2012.
GRANT, P.; RAMASAMY, S. An update on plant derived anti-androgens. Int Jn Endocrinol Metab;
10(2):497-502, 2012.
HAGENAU, et al. Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an
ecologic meta-regression analysis. Osteoporos Int; 20(1):133-40, 2009.
HAN, L. K.; MORIMOTO, C.; YU, R. H.; OKUDA, H. Effects of Coleus forskohlii on at storage in ovariectomized
rats. Yakugaku Zasshi; 125(5):449- 3, 2005.
HARADA, N.; OKAJIMA, K. Effect of topical application of capsaicin and its related compounds on dermal
insulin-like growth factor-I levels in mice and on facial skin elasticity in humans. Growth Horm IGF Res;
17(2):171-6, 2007.
HARDING, C. R.; LONG, S.; RICHARDSON, J.; ROGERS, J.; ZHANG, Z.; BUSH, A.; RAWLINGS, A. V. The
cornified cell envelope: an important marker of stratum corneum maturation in healthy and dry skin. Int
J Cosmet Sci; 25(4):157-67, 2003.
HASHMI, M. A.; KHAN, A.; HANIF, M.; FAROOQ, U.; PERVEEN, S. Traditional Uses, Phytochemistry, and
Pharmacology of Olea europaea (Olive). Evid Based Complement. Alternat Med.;2015:541591, 2015.
HATANAKA, E.; LEONARDO, M. P.; MARTINS, E. F.; LIBERTI, E. A. et al. Evidências do efeito pró-inlfamatório
dos ácidos oléico e linoléico no processo de cicatrização em ratos. II Simpósio sobre ácidos graxos e
saúde, São Paulo, 2006.
HAYAKAWA, et. al. The pigmentation melasma effect of alpha tocopheryl. Dermatol. Clin. J, 2008.
HE, D.; SUN, J.; ZHU, X.; NIAN, S.; LIU, J. Compound K increases type I procollagen level and decreases
matrix metalloproteinase-1 activity and level in ultraviolet-A-irradiated fibroblasts. J Formos Med Assoc;
110(3):153-60, 2011.
HENDERSON, S.; MAGU, B.; RASMUSSEN, C.; LANCASTER, S. et al. Effects of coleus forskohlii
supplementation on body composition and hematological profiles in mildly overweight women. J Int
Soc Sports Nutr; 9(2):54-62, 2005.
HENRICH, U.; NEUKAM, K.; TRONNIER, H. et al. Long-term ingestion a of high flavanol Cocoa
providesPhotoprotection aginst UV-induced erythema and improves skin conditional im women. J Nutr;
136:1565-1569, 2006.
HEXSEL, D.; ORLANDI, C.; ZECHMEISTER, D. O.; PRADO, D. Botanical extracts used in the treatment of
cellulite. Dermatol Surg.; 31(7 Pt 2):866-72; 2005.
HIRATA, L. L.; SATO, M. E. O.; SANTOS, C. A. M. Radicais livres e convelhecimento cutâneo. Acta Farm
Bonaerense; 23(3): 418-24, 2004.
20
Referências
HOFFMAN, E. Cytokines in alopecia areata. In: CAMACHO, F. M.; RANDALL, V. A.; PRICE, V. H. Hair and
its disorders. UK: Martin Dunitz, 2000.
HUNT, C. D. Regulation of enzymatic activity. One possible role of dietary boron in higher animals and
humans. Biol Trace Elem Res, 66:205–225, 1998.
HURSEL, R.; VIECHTBAUER, W.; DULLOO, A. G.; TREMBLAY, A.; TAPPY, L.; RUMPLER, W.; WESTERTERP-
PLANTENGA, M. S. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation:
a meta-analysis. Obes Rev.;12(7):e573-81, 2011.
HUSSAIN, A. I.; ANWAR, F.; CHATHA, S. A.; JABBAR, A.; MAHBOOB, S.; NIGAM, P. S. Rosmarinus officinalis
essential oil: antiproliferative, antioxidant and antibacterial activities. Braz J Microbiol; 41(4):1070-8, 2010.
IMAYAMA et al. A Hypotetical explanation for the aging of skin. Am.J. pathol, pp. 134-109, 1998.
INADERA, H. The usefulness of circulating adipokine levels for the assessment of obesity-related health
problems. Int J Med Sci; 5 (5): 248-62, 2008.
INGRAM, D. K.; ZHU, M.; MAMCZARZ, J. et al. Calorie restriction mimetics: ana emerging research field.
Aging Cell; 5: 97-108, 2006.
IWAMI, M.; MAHMOUD, F. A.; SHIINA, T.; HIRAYAMA, H. et al. Extract of grains of paradise and its active
principle 6-paradol trigger thermogenesis of brown adipose tissue in rats. Auton Neurosci; 161(1-2):
63-7, 2011.
JAMES, M. O.; SACCO, J. C.; FAUX, L. R. Effects of Food Natural Products on the Biotransformation of PCBs.
Environ Toxicol Pharmacol; 25(2): 211-217, 2008.
JATANA, S.; DELOUISE, L. A. Understanding engineered nanomaterial skin interactions and the modulatory
effects of ultraviolet radiation skin exposure. Wiley Interdiscip Rev Nanomed Nanobiotechnol;6(1):61-79,
2014.
JUNQUEIRA, L. C.; CARNEIRO, J. Histologia básica: texto e atlas. 12a ed. Rio de Janeiro: Guanabara
Koogan, 2013.
KADIISKA, M. B.; GLADEN, B. C.; BAIRD, D. D. et al. Biomarkers os oxidative stress study III. Free Radic
Biol Med; 38: 711-718, 2005.
KANG, N. J.; LEE, K. W.; SHIN, B. J.; JUNG, S. K.; HWANG, M. K.; BODE, A. M.; HEO, Y. S.; LEE, H. J.; DONG,
Z. Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced
COX-2 expression. Carcinogenesis.; 30(2):321-30, 2009.
KANG, T. H.; PARK, H. M.; KIM, Y. B.; KIM, H.; KIM, N.; DO, J. H.; KANG, C.; CHO, Y.; KIM, S. Y. Effects of red
ginseng extract on UVB irradiation-induced skin aging in hairless mice. J Ethnopharmacol; 123(3):446-
51, 2009.
KATSUDA, et al. Unsaturated ftty acid induced calcuim influx in keratinocytes and cause abnormal
differentiation of epidermis. J Invest Dermatol; 124(5):1008-13, 2005.
21
Referências
KIM, S. N.; KIM, S.; HONG, Y. D. et al. The ginsenosides of Panax ginseng promote hair growth via similar
mechanism of minoxidil. J Dermatol Sci;77(2):132-4, 2015.
KIM, Y. J. et al. Tehe anti-melanogenic effect of pycnogenol by its anti-oxidative actions. Food Chem
Toxicol, 46(7):2466-71, 2008.
KRABBE, K. S.; PEDERSEN, M.; BRUUNSGAAR, D. H. Inflammatory mediators in the elderly. Exp Gerontol;
39: 697-699. 2004.
LALA, G.; MALIK, M.; ZHAO, C. et al. Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer
in rats. Nutr Cancer; 54(1):84-93, 2006.
LEITE, H. P.; et al. Radicais Livres, anti-oxidantes e nutrição. Revista Brasileira Nutrição Clínica, São
Paulo, v. 18, n. 2, 2003.
LEY, R. E.; BACKHED, F.; FULTON, L.; et al. Obesity alters gut microbial ecology. PNAS; 31(102): 2005.
LEY, R. E.; LOZUPONE, C. A.; HAMADY, M.; et al. Worlds within worlds: evolution of the vertebrate gut
microbiota. Nat. Rev. Microbiol; 2008.
LIMA, C. F.; PEREIRA-WILSON. C.; RATTAN, S. I. Curcumin induces heme oxygenase-1 in normal human skin
fibroblasts through redox signaling: relevance for anti-aging intervention. Mol Nutr Food Resr; 55(3): 2011.
LIMA, F.; DE FALCO, V.; BAIMA, J.; CARAZZATO, J. G.; PEREIRA, R. M. Effect of impact load and active load
on bone metabolism and body composition of adolescent athletes. Med Sci Sports Exerc; 33: 2001.
LIMA, M. A. M.; SERRA, M. C. V. F. Novo enfoque no tratamento nutricional da queimadura. Ver Bras
Queim; 2(1): 2002.
LIU; J. The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving, ageassociated
mitochondrial and cognitive dysfunction: na overview. Neurochem Res; 33(1): 2008.
MAEDA, H.; HOSOKAWA, M.; SASHIMA, T.; FUNAYAMA, K.; et al. Fucoxanthin from edible seaweed, Undaria
pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys
Res Commun; 332(2): 2005.
MAGLICH, J. M.; WATSON, J.; MCMILLEN, P. J. et al. The nuclear receptor CAR is a regulator of thyroid
hormone metabolism during caloric restriction. J Biol Chem; 279: 2004.
MAGUIRE, L. S.; O’SULLIVAN, S. M.; GALVIN, K.; et al. Fatty acid profile, tocopherol, squalene and phytosterol
content of walnuts,almonds, peanuts, hazelnuts and the macadamia nut. Int J Food Sci Nutr; 55(3): 2004.
MASORO, E. J. Overview of caloric restriction an aging. Mech Ageing Dev; 126: 2005.
MATSUDA, N.; KOYAMA, Y.: HOSAKA, Y. et al. Efects of ingestion of collagen peptide on collagen and
glycosamiinoglycans in teh dermis. J Nutr Sci Vitaminol; 52: 2006.
MATSUZAKI, J.; KUWAMUR, M.; YAMAJI, R. et al. Inflammatory resposnses to lipopolysaccharide are
suppressed in 40% energy-restricted mice. J. Nutr; 131: 2001.
MEHTA, R. C.; FITZPATRICK, R. E. Endogenous growth factors as cosmeceuticals. Dermatol Ther; 20(5): 2007.
22
Referências
MICHAËLSSON, G.; JUHLIN, L.; VAHLQUIST, A. Effect of oral zinc and vitamin A in acne. Arch Dermatol;
113: 1977.
MIDDELKAMP-HUP, M. A.; PATHAK, M. A.; PARRADO, C.; GOUKASSIAN, D.; RIUS-DÍAZ, F.; MIHM, M. C.;
FITZPATRICK, T. B.; GONZÁLEZ, S. Oral Polypodium leucotomos extract decreases ultraviolet-induced
damage of human skin. J Am Acad Dermatol; 51(6):2004.
MILADINOVIĆ, B.; KOSTIĆ, M.; ŠAVIKIN, K.; ĐORĐEVIĆ, B.; MIHAJILOV-KRSTEV, T.; ŽIVANOVIĆ, S.; KITIĆ,
D. Chemical profile and antioxidative and antimicrobial activity of juices and extracts of 4 black currants
varieties (Ribes nigrum L.). J Food Sci; 79(3):C301-9, 2014.
MIYASHITA, K.; NISHIKAWA, S.; BEPPU, F.; TSUKUI, T.; et al. The allenic carotenoid fucoxanthin, a novel
marine nutraceutical from brown seaweeds. J Sci Food Agric; (7): 2011.
MOODLEY, R.; KINDNESS, A.; JONNALAGADDA, S. B. Elemental composition and chemical characteristics
of five edible nuts (almond, Brazil, pecan, macadamia and walnut) consumed in Southern Africa. J Environ
Sci Health; 42(5): 2007.
MURATA, K.; NOGUCHI, K.; KONDO, M.; ONISHI, M.; WATANABE, N.; OKAMURA, K.; MATSUDA, H. Promotion
of hair growth by Rosmarinus officinalis leaf extract. Phytother Res; 27(2): 2013.
MURRAY, J.; DARR, D.; REICH, J. Topical vitamin C treatment reduces ultraviolet B radiation-induced
erythema in human skin. J Invest Dermatol; 96: 1991.
NANASHIMA, N.; HORIE, K.; TOMISAWA, T.; CHIBA, M.; NAKANO, M.; FUJITA, T.; MAEDA, H.; KITAJIMA,
M.; TAKAMAGI, S.; UCHIYAMA, D.; WATANABE, J.; NAKAMURA, T.; KATO, Y. Phytoestrogenic activity of
blackcurrant (Ribes nigrum) anthocyanins is mediated through estrogen receptor alpha. Mol Nutr Food
Res; 2015.
NASSIRI-ASL, M.; HOSSEINZADEH, H. Review of the pharmacological effects of Vitis vinifera (Grape) and
its bioactive compounds. Phytother Res; 23(9): 2009.
NAVES, A. Nutrição Clínica Funcional: obesidade. São Paulo: Valéria Paschoal Editora Ldta., 2009.
NEILL, USHMA S. “Skin Care in the Aging Female: Myths and Truths.” The Journal of Clinical
Investigation 122.2 (2012): 473–477. PMC. Web. 21 Nov. 2015.
NESTOR, M.; BUCAY, V.; CALLENDER, V.; COHEN, J. L.; SADICK, N.; WALDORF, H. Polypodium leucotomos
as an Adjunct Treatment of Pigmentary Disorders. J Clin Aesthet Dermatol; 7(3):2014.
NI, Z.; MU, Y. Treatment of melasma with Picnogenol. Beijing Nutriment Science Tecnology, 2002.
ORIA, Reinaldo B. et al. Estudo das alterações relacionadas com a idade na pele humana, utilizando
métodos de histo-morfometria e autofluorescência. An. Bras. Dermatol. [on-line]. v. 78, n. 4, 2003. ISSN
1806-4841.
ORTOLANI, C. et al. Food allergies and food intolerances. Best pract Res clin Immunol; 2(3): 2006.
OSTOJIC, S. M. Yohimbine: the effects on body composition and exercise performance in soccer players.
Res Sports Med; 14(4): 2006.
23
Referências
OYETAKINWHITE, P.; TRIBOUT, H.; BARON, E. Protective mechanisms of green tea polyphenols in skin.
Oxid Med Cell Longev; 2012:560682. (Epub).
PALANISAMY, U. D.; LING, L. T.; MANAHARAN, T.; SIVAPALAN, V.; SUBRAMANIAM, T.; HELME, M. H.;
MASILAMANI, T. Standardized extract of Syzygium aqueum: a safe cosmetic ingredient. Int J Cosmet
Sci; 33(3): 2011.
PARK, G. H.; PARK, K. Y.; CHO, H. I. Ginseng extract promotes the hair growth in cultured human hair
follicles. J Med Food; 18(3): 2015.
PARK, S. K.; PROLLA,T. A. Gene expression profiling studies of aging in cardiac and skeletal muscles.
Cardiocasc Res; 66: 2005.
PARRY, J.; SU, L.; LUTHER, M.; et al. Fatty acid composition and antioxidant properties of cold-pressed
marionberry, boysenberry, red raspberry, and blueberry seed oils. J Agric Food Chem; 53(3): 2005.
PATEL, M. S.; SRINIVASAN, M. Metabolic programming: causes and consequences. J Biol Chem; 277(3):
2002.
PENNA, G.; AMUCHASTEGUI, S.; GIARRATANA, N.; DANIEL, K. C.; VULCANO, M.; SOZZANI, S.; ANDORINI, L.
1,25-di-hidroxyvitamin D3 selectively modulates tolerogenic proprietes in myeloid but not plasmacytoid
dendritic cells. J Immunol; 178(1): 2007.
PICARD, F.; KURTEV, M.; CHUNG, N. et al. Sirt 1promotes fat mobilization in wgite adipocytes by repressing
PPAR-gama. Nature; 429: 2004.
PIRER, M. D.; SELMAN, C.; MICELWEE. J. J. et al. Separating cause from effect: how does insulin IGF signaling
control lifespan in worms, filies and mice? J Intern Med; 283-(2): 2008.
PITTLER, M. H, SCHMIDT, K.; ERNST, E. Adverse events of herbal food supplements for body weight
reduction: systematic review. Obes Rev; 6(2): 2005.
PODDA, M.; GRUNDMANN-KOLLMANN, M. Low molecular weight antioxidants and their role in skin
ageing. Clinical and experimental dermatology; 26: 2001.
POVOA, Guilherme; DINIZ, Lucia Martins. O Sistema do Hormônio de Crescimento: interações com a
pele. An. Bras. Dermatol. [online]. v. 86, n. 6, 2011. ISSN 0365-0596.
PREMKUMAR, K.; ABRAHAM, S. K.; SANTHIYA, S. T.; RAMESH, A. Protective effect of Spirulina fusiformis
on chemical-induced genotoxicity in mice. Fitoterapia; 75(1): 2004.
RAHMAN, I.; BISWAS, S. K.; KIRKHAM, P. A. Regulation of inflammation and redox signaling by dietary
polyphenols. Biochem Pharmacol; 72(11): 2006.
RAMALHO, R. et al. Papel do tecido adiposo e dos macrófagos no estado de inflamação crônica associada
à obesidade. Acta Med Port; 21(5): 2008.
24
Referências
RAVELLI, G. P.; STEIN, Z. A.; SUSSER, M. W. Obesity in young men after famine exposure in utero and early
infancy. N Engl J Med; 12;295(7): 1976.
REAGAN-SHAW, S.; AFAQ, F.; AZIZ, M. H.; AHMAD, N. Modulations of critical cell cycle regulatory
events during chemoprevention of violet B-mediated responses by resveratrol in SKH-1 hair-less
mouse skin. 2004.
REZNICK, R. M.; ZONG, H.; LI, J. et al. Aging-Associated Reduction in AMP-Activated Protein Kinase Activity
and Mitocondrial Biogenesis. Cell Metab; 5: 2007.
RINGMAN, J. M. et al. Apotential role of the curry spice curcumin in Alzheimer’s disease. Curr Alzheimer
Res; 2(2): 2005.
ROBINSON, L. E; BUCHHOLZ, A. C.; MAZURAK, V. C. Inflammation, obesity, and fatty acid metabolism:
influence of n-3 polyunsaturated fatty acids on factors contributing to metabolic syndrome. Appl Physiol
Nutr Metab; 32 (6): 2007.
ROSSI, A. B.; VERGNANINI, A. L. Cellulite: a review. J Eur Acad Dermatol Venereol; 14(4): 2000.
SHARMA, S. R.; PODDAR, R.; SEN, P.; ANDREWS, J. T. Effect of vitamin C on collagen biosynthesis and
degree of birefringencein polarization sensitive optical coherence tomography (OS-OCT). African Journal
of Biotechnology; v. 7 (12), 2008.
SAVIKIN, K.; MENKOVIĆ, N.; ZDUNIĆ, G.; PLJEVLJAKUŠIĆ, D.; SPASIĆ, S.; KARDUM, N.; KONIĆ-RISTIĆ, A.
Dietary supplementation with polyphenol-rich chokeberry juice improves skin morphology in cellulite. J
Med Food; 17(5):582-7, 2014.
SCHAUSS, A. G.; WU, X.; PRIOR, R. L. et al. Antioxidant capacity and other bioactivities of the freeze-dried
Amazonian palm berry, Euterpe oleraceae mart. (acai). J Agric Food Chem; 54(22): 2006.
SCHRADER, A.; SIEFKEN, W.; KUEPER, T.; BREITENBACH, U.; GATERMANN, C.; SPERLING, G.; BIERNOTH,
T.; SCHERNER, C.; STÄB, F.; WENCK, H.; WITTERN, KP.; BLATT, T. Effects of glyceryl glucoside on AQP3
expression, barrier function and hydration of human skin. Skin Pharmacol Physiol; 25(4): 2012.
SELVAM, R. et al. The antioxidant activity of tumric (Curcuma longa). J Ethonopharmacol; 47: 1995.
SERAFINI; M. R.; GUIMARÃES, A. G.; QUINTANS, J. S.; ARAÚJO, A. A.; NUNES, P. S.; QUINTANS-JÚNIOR,
L. J. Natural compounds for solar photoprotection: a patent review. Expert Opin Ther Pat; 25(4): 2015.
SHAARAWY, S. M. et al. Protective effects of garlic and silymarin on NDEA – induced rats hepatotoxicity.
Int J Biol Sci; 5: 2009.
SHAHIDI, F. Omega-3 oils: sources, applications, and health effects. In: BARROW, C.; SHAHIDI, F. Marine
Nutraceuticals and Functional Foods. Boca Raton, FL: CRC Press, 2008.
SHEMSHIAN, M.; MOUSAVI, S. H.; NOROUZY, A.; KERMANI, T.; MOGHIMAN, T.; SADEGHI, A.; GHAYOUR-
MOBARHAN, M.; FERNS, G. A. Saffron in metabolic syndrome: its effects on antibody titers to heat-shock
proteins 27, 60, 65 and 70. J Complement Integr Med. 6;11(1): 2014.
25
Referências
SILVA, W. S.; HARNEY, J. W.; KIM, B. W. et al. The Small Polyphenolic Molecule Kaempferol Increases Cellular
Energy Expenditure and Thyroid Hormone Activation. Diabetes; 56: 2007.
SILVEIRA et al. Teor de Polifenois e composição quimica do mirtilo do grupo Highush. 2007.
SMITH, R. G.; BETANCOURT, L.; SUN. Y. Molecular endocrinology and physiology of the aging central
nervous system. Endocr Ver; 26: 2005.
SOHAL, R. S.; AGARWAL, S.; CANDAS, M. et al. Effect of age and caloric restrition on DNA oxidative damage
in different tissues of C57BL / 6 mice. Mech Ageing Dev; 76: 1994.
SÖKMEN, B.; ARMSTRONG, L. E.; KRAEMER, W. J. et al. Caffeine use in sports: considerations for the athlete.
J Strength Cond Res; 22(3): 2008.
STANLEY, S; WYNNE, K; MC GOWAN, B. et al. Hormonal regulation of food intake. Physiol Rev; 86: 1131-
1158, 2005.
STEVENSON, D. G.; ELLER, F. J.; WANG, L. Oil and tocopherol content and composition of pumpkin seed
oil in 12 cultivars. J Agric Food Chem; 55(10): 2007.
SUMIYOSHI, M.; KIMURA, Y. Effects of olive leaf extract and its main component oleuroepin on acute
ultraviolet B irradiation-induced skin changes in C57BL/6J mice. Phytother Res; 24(7): 2010.
TOYODA, M.; MOROHASHI, M. Pathogenesis of acne. Med Electron Microsc; 34: 2001.
TSAI, S. H.; LIN-SHIAU, S. Y.; LIN, J. K. Suppression of nitric oxide synthase and the down-regulation
of the activation of NFappaB in macrophages by resveratrol. 1999.
TURNBAUGH, P. J.; BÄCKHED, F.; FULTON, L. et al. Diet-induced obesity is linked to marked but reversible
alterations in the mouse distal gut microbiome. Cell Host Microbe. 3: 2008.
VAGIRI, M.; EKHOLM, A.; ANDERSSON, S. C.; JOHANSSON, E.; RUMPUNEN, K. An optimized method for
analysis of phenolic compounds in buds, leaves, and fruits of black currant (Ribes nigrum L.). J Agric
Food Chem; 60: 2012.
VALDÉS, J. A.; HIDALGO, J.; GALAZ, J. L.; et al. NF-kappaB activation by depolarization o skeletal muscle cells
depends on ryanodine and IP3 receptor-mediated calcium signals. Am J Physiol Cell Physiol; 292(5): 2007.
VARGAS, D. M.; AUDI, L.; CARRASCOSA, A. Peptídeos derivados do colágeno: novos marcadores
bioquimicos do metabolismo ósseo. Ver Ass Med Brasil. 43(4); 1997.
VASTO, S.; MOCCHEGIANI, E.; CANDORE, G.; et al. Inflammation, genes and zinc in ageing and age-related
diseases. Biogerontology; 7(5-6): 2006.
26
Referências
VÁZQUEZ, P. D. E.; SANDOVAL, M. R. D. M. Acne, dieta y debate: un veredicto pendiente. Med Interna
México. 24(5): 2008.
VERKMAN, A. S. More than just water channels: unexpected cellular roles of aquaporins. J Cell Sci. 118(Pt
15): 2005.
VINCENT, H. K.; INNES, K. E.; VINCENT, K. R. Oxidative stress and potential interventions to reduce oxidative
stress in overweight and obesity. Diabetes Obes Metab; 9(6): 2007.
VIRTANEN, K. A.; LIDELL, M. E.; ORAVA, J.; HEGLIND, M.; WESTERGREN, R.; NIEMI, T.; TAITTONEN, M.; LAINE,
J.; SAVISTO, N. J.; ENERBÄCK, S.; NUUTILA, P. Functional brown adipose tissue in healthy adults. N Engl
J Med. 9;360(15): 2009.
VOWELS, B. R.; YANG, S.; LEYDEN, J. J. Induction of proinflammatory cytokines by soluble factor os
Propionibacterium acnes implications for chronic inflammatory acne. Infect immune. 63(8): 1995.
VOWELS, B. R.; YANG, S.; LEYDEN, J. J. Induction of proinflammatory cytokines by a soluble factor of
Propionibacterium acne: implications or chronic inflammatory ance. Infect Immun; 63(8): 1995.
WAITZBERG, D. Nutrição oral, enteral e parenteral na prática clínica. 3a ed. São Paulo: Atheneu, 2001.
WANG, L.; MENG, X.; ZHANG, F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic
steatohepatitis. J Med Food. 15(5): 2012.
WANG, S. Y.; FENG, R.; BOWMAN, L.; PENHALLEGON, R.; DING, M.; LU, Y. Antioxidant activity in lingonberries
(Vaccinium vitis-idaea L.) and its inhibitory effect on activator protein, nuclear factor-kappaB, and
mitogenacvated protein kinases activation. J Agric Food Chem; 20;53 (8): 3156-66, 2005.
WATERLAND, R. A.; GARZA, C. Potential mechanisms of metabolic imprinting that lead to chronic disease.
American Journal Clinical Nutrition. 69: 1999.
WEINDRUCH, R.; SOHAL, R. S. Caloric intake ad aging. N Engl J Med; 337: 1997.
WERBACH, M. A cura através da nutrição: uma abordagem natural do tratamento de 50 doenças comuns
com dietas e nutrientes. Rio de Janeiro: Revinter, 2001.
WITE, M. B.; BARBUL, A. Arginine physiology and its implication fro wound healing. Repair Regen, 11: 2003.
WOLF, R.; MATZ, H.; ORION, E. Acne and diet. Clin Dermatol. 22(5): 2004.
WOO, M. N.; JEON, S. M.; SHIN, Y. C.; LEE, M. K. et al. Anti-obese property of fucoxanthin is partly mediated
by altering lipid-regulating enzymes and uncoupling proteins o f visceral adipose tissue in mice. Mol
Nutr Food Res. 53(12): 2009.
YAMAGISHI, S.; NAKAMURA, K.; INOUE, H. Therapeutic potentials of unicellular green alga Chlorella in
advanced glycation end product (AGE)-related disorders. Med Hypotheses. 65(5): 2005.
YAMAMOTO, J. Role of active oxygen species and antioxidants in photoaging. J Dermatol Sci. 27(1): 2001.
YEUNG, F.; HOBERG, J. E.; KAMSEY, C. S. et al. Modulation of NF-kB deacetylase. EMBO J; 23: 2004.
27
Referências
YONESHIRO,T.; AITA, S.; KAWAI, Y.; IWANAGA, T.; SAITO, M. Nonpungent capsaicin analogs (capsinoids)
increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr;
95(4): 2012.
YONESHIRO, T.; AITA, S.; MATSUSHITA, M.; OKAMATSU-OGURA, Y.; KAMEYA, T.; KAWAI, Y.; MIYAGAWA, M.;
TSUJISAKI, M.; SAITO, M. Age-related decrease in cold-activated brown adipose tissue and accumulation
of body fat in healthy humans. Obesity (Silver Spring). 19(9): 2011.
ZAGUE, V. A new view concertiing the a Vects of collagen hydrolysate intake on skin properties. Arch
Dermatol Res; 300(9): 2008.
ZELKO, I. N.; MARIANI, T. J.; FOLZ, R. J. Superoxide dismutase multigene family: a comparison of the
CuZn-SOD (SOD1), Mn-SOD (DOS2), and EC-SOC (DOS3) gene structures, evolution, and axpression.
Free Radic Biol Med, 33(3): 2002.
ZEMPLENI, J.; MOCK, D. M. Marginal biotin deficiency is taretogenic. Proc Soc Exp Biol Med; 223 (1): 2000.
ZHANG, W.; HAN, Y.; LIM, S. L.; LIM, L. Y. Dietary regulation of P-gp function and expression. Expert Opin
Drug Metab Toxicol.; 5(7): 2009.
ZHU, Y.; XIA, M.; YANG, Y.; LIU, F.; LI, Z.; HAO, Y.; MI, M.; JIN, T.; LING, W. Purified anthocyanin
supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic
individuals. Clin Chem. 57: 2011.
ZI, S. X.; MA, H. J.; LI, Y.; LIU, W.; YANG, Q. Q.; ZHAO, G.; LIAN, S. Oligomeric proanthocyanidins from
grape seeds effectively inhibit ultraviolet-induced melanogenesis of human melanocytes in vitro. Int J
Mol Med. 23(2): 2009.
28