Pathophysiology of Chorioamnionitis

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Pathophysiology of Chorioamnionitis  about 5 to 10% of

infected babies
develop
pneumonia (lung
Predisposing Factors: infection) or
 young age (e.g., less than 21 years old); bacteremia
(however, this is
 low socioeconomic status;
more common in
 first pregnancy; preterm infants);
 long labor;  less than 1% of
 prolonged rupture of the membranes (bag of waters); term infants and a
 rupture of membranes at an early gestational age; slightly higher
percentage of
 multiple vaginal examinations during labor (only in women with preterm infants
ruptured membranes); develop meningitis
 pre-existing infections of the lower genital tract (bacterial vaginosis (infection of the
and group B streptococcal infection); and lining of the brain
 internal fetal and uterine monitoring. and spinal cord);
and
 although death in
term babies is
very unusual, up
to 15% of infected
Chorioamnionitis usually develops when bacteria that are part of the normal vaginal flora "ascend" into the
preterm infants die
uterine cavity. The amniotic fluid and placenta, as well as the baby, become infected. E. coli, group B because of the
streptococci, and anaerobic bacteria are the most common causes of chorioamnionitis, though, E. coli and infection or other
group B streptococci are also the two most common causes of infection in newborns. complications
such as
respiratory
distress syndrome
and bleeding into
Chorioamnionitis can lead to serious complications in both the brain.
mother and baby and is usually considered a medical
emergency

Fever in the mother

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