Drugs For Tuberculosis
Drugs For Tuberculosis
Drugs For Tuberculosis
STREPTOMYCIN
Ø Aminoglycoside
Ø Used commonly due to higher prevalence of M. tuberculosis resistance
Ø In combination vs. life-threathening tuberculous disease
o Meningitis
o Military dissemination
o Severe organ tuberculosis
DRUGS FOR LEPROSY
Dapsone (Diaminodiphenylsulfone)
Ø Most active against M. leprae
Ø MOA:
o Inhibition of folic acid synthesis
Ø Resistance
o Use in combinations to delay
o Rifampicin + dapsone
o Rifampicin + clofazimine
Ø Pharmacokinetics
o Absorption: Orally
o Penetration: well in tissues
o Enterohepatic cyclincling
o Elimination:
§ Urine
§ Acetylated metabolites
Ø Adverse effects
o GI irritation
o Fever
o Skin rashes
o Methemoglobinemia
o Hemolysis (G6PDH deficiency)
Acedapsones (Sulfones)
Ø Repository form of dapsone (cheaper)
Ø Long-term effect (Inhibitory plasma conc. For several months)
Ø Uses
o Leprosy
o Pneumocystis jirovecii pneumonia (AIDS patient)
Clofazimine (others)
Ø Phenazine dye
Ø Interact with DNA
Ø Adverse Effects:
o GI irritation
o Skin discoloration
§ Red-brown to black