WOLLEGA UNIVERSIY

Institution of Health Science

PART I: Choose the best answer from the following question.

1. The most commonly used antacids are the mixture of aluminum and magnesium
hydroxide because:
A. They have balanced constipating and laxative effect
B. They are devoid of metabolic alkalosis effect
C. They have no gastric distension, belching and flatulence side effect.
D. All of the above
2. Which laxative should not be used to treat acute constipation because of its slow onset of
action?
A. Glycerin C. Bisacodyl suppository
B. Psyllium D. Milk of magnesia
3. Which of the following statements adequately describes bulk-forming laxatives?
A. Can cause diarrhea if not taken with water
B. Are derived from polysaccharides and resemble fiber (bran) in mechanism of action
C. Onset of action is in 4–8 hours
D. Produce much more complete evacuation of constipation than stimulant products
4. The approved indication for misoprostol is
A. Gastro esophageal reflex disease ( GERD)
B. Pathologic hyper secretory condition such as zollinger - Ellison syndrome
C. Inflammatory bowel disease
D. Prevention of gastric ulceration in patients using large dose of aspirin – like drugs
5. One of the following combination of drugs give maximum eradication of H. pylori with
minimum extra side effects in treatment of PUD accompanied by H.Pylori
A. Ranitidine (400mg BID) for 28 days + Clarithromycin (500mg TID) for 14days
B. Lansoprazole (30mg BID) + Amoxicillin ( 1g BID) + Clarithromycin ( 500mg BID)
for 14 days
C. Bismuth subsalicylate ( 525mg QID) + Metronidazole (250mg QID) + Tetracycline
(500 mg QID) + Omeprazole ( 20mg BID) for 7 days
D. Cimetidine ( 400mg BID) + Tetracycline ( 500 mg QID) + Clarithromycin (500mg
TID) for 21 days
6. The most potent effective and ideal class of antiulcer drug currently available for
treatment of PUD and GERD is:
A. Antacids B. PPI C. H2 receptor antagonist D. Mucosal protectants
7. A drug that cause gynecomastia, impotence and galactorrhea during its clinical use
A. Omeprazole B. Cimetidine C. Ranitidine D. Misoprostol
8. Which of the following antacids is associated with secondary constipation?
A. Aluminum hydroxide C. Sodium bicarbonates
B. Magnesium hydroxide D. Magaldrate
9. This antibiotic is not appropriate for use as an oral agent in the treatment of recurrent
peptic ulcer associated with Helicobacter pylori
A. Amoxicillin C. Clarithromycin
B. Metronidazole D. Vancomycin
10. The plasma half – life of PPIs is short (about 1.5 hr) but their acid inhibition effect is
prolonged (more than 24hr). Why? Because they:
A. Irreversibly inhibit K+ , H+ -ATPase ( proton pump ) activity
B. Only concentrated in parietal cell canaliculi
C. Block all factors stimulated acid secretion
D. Inhibit the terminal pathways of acid production
11. A mucosal protecting agent used in eradication of H- Pylori ( in quadruple therapy )
A. Omeprazole B. Bismuth subsalicylate C. Sucralfate D. Misoprostol
12. The antiemetic drug mainly used for the treatment and prevention of motion sickness:
A. Odansetron B. Atropine C. Scopolamine D. Metoclopramide
13. One of the following classes of drugs is specific antidiarrheal:
A. Bile- salt binding resin C. Opioid analgesic
B. Antispasmodics D. Antibiotics
14. A patient with Zollinger–Ellison syndrome has been receiving high doses of cimetidine
for 7 weeks. A frequent adverse effect of cimetidine is
A. Agranulocytosis
B. Systemic lupus erythematosus
C. Inhibition of hepatic metabolism of other drugs
D. Antiestrogenic effects
15. Which one of the following drug inhibits acetylcholine- mediated secretion of HCl.
A. Misoprostol C. Pirenzepine
B. Pantoprazole D. Bismuth subsalicylate
16. From the following antiemetic drugs one is specifically block H1 receptor & muscarinic
receptor in the pathway from the inner ear to the VC.
A. Dimenhydrinate C. Scopolamine
B. Metoclopramide D. Ondansetron
17. From the following GI medications one reduce the absorption of co-administered drug
like tetracycline and fluoroquinolones by forming chelation.
A. Ranitidine C. Esomeprazole
B. Pirenzepine D. Magnesium hydroxide
18. A mucosal protecting agent used in eradication of H- Pylori (in quadruple therapy).
A. Omeprazole B. Bismuth subsalicylate C. Sucralfate D. Misoprostol
19. Which one of the following antacid causes milk- alkali syndrome when it’s used with
milk?
A. Calcium carbonate C. Sodium bicarbonate
B. Magnesium hydroxide D. Aluminum hydroxide
20. Wrong about Bisacodyl
A. Administered via rectally & orally
B. Not used with antacids & milk
C. Should not be used for more than 10 consecutive days.
D. Grouped under surfactant laxatives
21. The common bacteria that can cause traveler's diarrhea is
A. Helicobacter pylori( H Pylori) C. Pseudomonas euroginosa
B. Escherichia coli (E Coli) D. Salmonella typhi
22. Mechanistically, which of the following drugs will decrease stomach acid secretion by
blockade of H2 receptors?
A. Bisacodyl B. Misoprostol C. Omeprazole D. Ranitidine

Part II. Write the following questions accordingly.

1. Classify laxative based on their mechanisms of action. (3pt)

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2. Write common causes of peptic ulcer disease. (2 pt)

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3. List out the 4 major group of antiulcer medications. (3pt)

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Good luck!!!
Sagni Hanbisa (B.Pharm, MSc in Pharmacology)